通过单细胞 RNA 测序揭示慢性鼻窦炎的细胞微环境:应用与未来方向

IF 8.4 2区 医学 Q1 ALLERGY Clinical Reviews in Allergy & Immunology Pub Date : 2024-04-30 DOI:10.1007/s12016-024-08992-6
Yuzhuo Liu, Wei Lv, Weiqing Wang
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引用次数: 0

摘要

慢性鼻炎(CRS)是一种以持续性上呼吸道粘膜炎症为特征的异源性疾病。对 CRS 的研究已从基于表型发展到基于内型,对分子生物标志物、信号通路和免疫微环境进行了更深入的研究。单细胞 RNA 测序是在转录组水平分析疾病微环境中细胞组成、功能和相互作用的有效工具,在无偏见地分析慢性气道炎症的潜在生物标志物、发病机制和异质性方面显示出巨大优势。在本文中,我们将综述 CRS scRNA-seq 研究的最新进展,为这种异质性疾病的诊断和治疗提供新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Uncovering the Cellular Microenvironment in Chronic Rhinosinusitis via Single-Cell RNA Sequencing: Application and Future Directions

Chronic rhinosinusitis (CRS) is a heterogenic disease characterized by persistent mucosal inflammation of the upper airway. Researches of CRS have progressed from phenotype-based to endotype-based, looking more deeply into molecular biomarkers, signaling pathways, and immune microenvironment. Single-cell RNA sequencing is an effective tool in analyzing composition, function, and interaction of cells in disease microenvironment at transcriptome level, showing great advantage in analyzing potential biomarkers, pathogenesis, and heterogeneity of chronic airway inflammation in an unbiased manner. In this article, we will review the latest advances in scRNA-seq studies of CRS to provide new perspectives for the diagnosis and treatment of this heterogeneous disease.

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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
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