新生儿卡介苗接种对恶性疟原虫体外细胞因子反应的影响

IF 2.9 4区 医学 Q3 IMMUNOLOGY BMC Immunology Pub Date : 2024-04-30 DOI:10.1186/s12865-024-00611-5
NL Messina, M Wang, EK Forbes, B Freyne, WP Hasang, S Germano, R Bonnici, F Summons, K Gardiner, S Donath, R Gordon, SJ Rogerson, N Curtis
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引用次数: 0

摘要

卡介苗(Bacillus Calmette-Guérin,BCG)对与结核病无关的感染具有脱靶保护作用。其中,小鼠和人体研究表明,接种卡介苗可预防疟疾。我们研究了卡介苗接种是否会影响新生儿对恶性疟原虫的体外细胞因子反应。我们收集了墨尔本婴儿研究卡介苗减少过敏和感染(MIS BAIR)随机对照试验(临床试验注册号 NCT01906853,2013 年 7 月注册)的 108 名参与者的血样,这些参与者在随机接种新生儿卡介苗(66 人)或未接种卡介苗(42 人)七天后接种卡介苗。用恶性疟原虫感染的红细胞(PfIE)或大肠杆菌刺激后,测量体外细胞因子反应。接种过卡介苗的新生儿和未接种过卡介苗的新生儿在受到恶性疟原虫感染红细胞或大肠杆菌刺激后,所测得的细胞因子没有差异。然而,采血年龄与细胞因子对PfIE反应的改变有独立关联。男性也与新生儿对PfIE和大肠杆菌的TNF-a反应增加有关。这些发现并不支持卡介苗接种在影响新生儿对恶性疟原虫的体外细胞因子反应中发挥作用。年龄较大的新生儿更有可能出现恶性疟原虫诱导的IFN-γ和IFN-γ诱导的趋化因子反应,这些反应与早期疟疾防护和疟疾发病机制有关。
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The influence of neonatal BCG vaccination on in vitro cytokine responses to Plasmodium falciparum
Bacillus Calmette–Guérin (BCG) vaccination has off-target protective effects against infections unrelated to tuberculosis. Among these, murine and human studies suggest that BCG vaccination may protect against malaria. We investigated whether BCG vaccination influences neonatal in vitro cytokine responses to Plasmodium falciparum. Blood samples were collected from 108 participants in the Melbourne Infant Study BCG for Allergy and Infection Reduction (MIS BAIR) randomised controlled trial (Clinical trials registration NCT01906853, registered July 2013), seven days after randomisation to neonatal BCG (n = 66) or no BCG vaccination (BCG-naïve, n = 42). In vitro cytokine responses were measured following stimulation with P. falciparum-infected erythrocytes (PfIE) or E. coli. No difference in the measured cytokines were observed between BCG-vaccinated and BCG-naïve neonates following stimulation with PfIE or E. coli. However, age at which blood was sampled was independently associated with altered cytokine responses to PfIE. Being male was also independently associated with increased TNF-a responses to both PfIE and E. coli. These findings do not support a role for BCG vaccination in influencing in vitro neonatal cytokine responses to P. falciparum. Older neonates are more likely to develop P. falciparum-induced IFN-γ and IFN-γ-inducible chemokine responses implicated in early protection against malaria and malaria pathogenesis.
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来源期刊
BMC Immunology
BMC Immunology 医学-免疫学
CiteScore
5.50
自引率
0.00%
发文量
54
审稿时长
1 months
期刊介绍: BMC Immunology is an open access journal publishing original peer-reviewed research articles in molecular, cellular, tissue-level, organismal, functional, and developmental aspects of the immune system as well as clinical studies and animal models of human diseases.
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