Hacı Arak, Umut Elboga, Yusuf Burak Cayirli, Aydın Aytekin
{"title":"68 Ga-FAPI PET/CT 对各种癌症骨转移患者的预后意义","authors":"Hacı Arak, Umut Elboga, Yusuf Burak Cayirli, Aydın Aytekin","doi":"10.1007/s12149-024-01935-3","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to compare <sup>18</sup>FDGPET/CT in patients who develop bone metastases due to various cancers and to investigate the prognostic significance of the <sup>68</sup>FAPI-PET/CT SUVmax value for survival.</p><h3>Methods</h3><p>Patients with bone metastases who underwent both <sup>68</sup> Ga-FAPI PET/CT and <sup>18</sup>FDGPET/CT within a 1 week period were included in this retrospective study. The effect of the SUVmax value of bone lesions on overall survival was analyzed.</p><h3>Results</h3><p>A total of 75 eligible patients with 139 bone lesions were included in this study. The median age of the patients was 55 (30–83) and 48(64%) patients were newly diagnosed. The primary lesion median <sup>68</sup> Ga-FAPI PET/CT SUVmax value was higher than the median <sup>18</sup>FDGPET/CT SUVmax (10.75 versus 6.7). Bone lesions <sup>68</sup> Ga-FAPI PET/CT SUVmax median (IQR) were 7.8 (4.6–13.2), and <sup>18</sup>FDGPET/CT SUVmax of bone lesions were 5.9 (3.8–8.2). More bone lesions were detected on <sup>68</sup> Ga-FAPI PET/CT than on <sup>18</sup>FDGPET/CT(median IQR 4 [1–9] versus 2 [1–6] (<i>p</i> = 0.014). The extra lesions observed on <sup>68</sup> Ga-FAPI PET/CT were mostly sclerotic bone lesions (<i>p</i> = 0.001).<sup>68</sup> Ga-FAPI PET/CT SUVmax was significantly higher in vertebra and thorax lesions (<i>p</i> = 0.011 and <i>p</i> = 0.018, respectively). While the bone lesion <sup>68</sup> Ga-FAPI PET/CT SUVmax affected the OS, the <sup>18</sup>FDGPET/CT SUVmax value did not affect the OS (<i>p</i> < 0.001 and <i>p</i> = 0.079, respectively). In ROC analysis, a cut-off-off value of <sup>68</sup> Ga-FAPI PET/CT SUVmax > 7.7 was found for OS (AUC: 0.619). The median OS in the group above the cut-off value was worse than that in the group below the cut-off value (32 versus 45) months (<i>p</i> = 0.002). In the multivariate analysis for OS, the <sup>68</sup> Ga-FAPI PET/CT SUVmax of bone lesions was an important parameter, as well as cancer subtype, ALP level, and disease occurrence.</p><h3>Conclusions</h3><p><sup>68</sup> Ga-FAPI PET/CT detected more bone lesions and higher SUVmax values than <sup>18</sup>FDGPET/CT in various cancers. The prognostic value of the SUVmax value of <sup>68</sup> Ga-FAPI PET/CT bone lesions was observed regardless of disease subtype.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 8","pages":"630 - 638"},"PeriodicalIF":2.5000,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prognostic significance of 68 Ga-FAPI PET/CT in patients with bone metastases in various cancers\",\"authors\":\"Hacı Arak, Umut Elboga, Yusuf Burak Cayirli, Aydın Aytekin\",\"doi\":\"10.1007/s12149-024-01935-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>This study aimed to compare <sup>18</sup>FDGPET/CT in patients who develop bone metastases due to various cancers and to investigate the prognostic significance of the <sup>68</sup>FAPI-PET/CT SUVmax value for survival.</p><h3>Methods</h3><p>Patients with bone metastases who underwent both <sup>68</sup> Ga-FAPI PET/CT and <sup>18</sup>FDGPET/CT within a 1 week period were included in this retrospective study. The effect of the SUVmax value of bone lesions on overall survival was analyzed.</p><h3>Results</h3><p>A total of 75 eligible patients with 139 bone lesions were included in this study. The median age of the patients was 55 (30–83) and 48(64%) patients were newly diagnosed. The primary lesion median <sup>68</sup> Ga-FAPI PET/CT SUVmax value was higher than the median <sup>18</sup>FDGPET/CT SUVmax (10.75 versus 6.7). Bone lesions <sup>68</sup> Ga-FAPI PET/CT SUVmax median (IQR) were 7.8 (4.6–13.2), and <sup>18</sup>FDGPET/CT SUVmax of bone lesions were 5.9 (3.8–8.2). More bone lesions were detected on <sup>68</sup> Ga-FAPI PET/CT than on <sup>18</sup>FDGPET/CT(median IQR 4 [1–9] versus 2 [1–6] (<i>p</i> = 0.014). The extra lesions observed on <sup>68</sup> Ga-FAPI PET/CT were mostly sclerotic bone lesions (<i>p</i> = 0.001).<sup>68</sup> Ga-FAPI PET/CT SUVmax was significantly higher in vertebra and thorax lesions (<i>p</i> = 0.011 and <i>p</i> = 0.018, respectively). While the bone lesion <sup>68</sup> Ga-FAPI PET/CT SUVmax affected the OS, the <sup>18</sup>FDGPET/CT SUVmax value did not affect the OS (<i>p</i> < 0.001 and <i>p</i> = 0.079, respectively). In ROC analysis, a cut-off-off value of <sup>68</sup> Ga-FAPI PET/CT SUVmax > 7.7 was found for OS (AUC: 0.619). The median OS in the group above the cut-off value was worse than that in the group below the cut-off value (32 versus 45) months (<i>p</i> = 0.002). In the multivariate analysis for OS, the <sup>68</sup> Ga-FAPI PET/CT SUVmax of bone lesions was an important parameter, as well as cancer subtype, ALP level, and disease occurrence.</p><h3>Conclusions</h3><p><sup>68</sup> Ga-FAPI PET/CT detected more bone lesions and higher SUVmax values than <sup>18</sup>FDGPET/CT in various cancers. The prognostic value of the SUVmax value of <sup>68</sup> Ga-FAPI PET/CT bone lesions was observed regardless of disease subtype.</p></div>\",\"PeriodicalId\":8007,\"journal\":{\"name\":\"Annals of Nuclear Medicine\",\"volume\":\"38 8\",\"pages\":\"630 - 638\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-04-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Nuclear Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12149-024-01935-3\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Nuclear Medicine","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12149-024-01935-3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Prognostic significance of 68 Ga-FAPI PET/CT in patients with bone metastases in various cancers
Objective
This study aimed to compare 18FDGPET/CT in patients who develop bone metastases due to various cancers and to investigate the prognostic significance of the 68FAPI-PET/CT SUVmax value for survival.
Methods
Patients with bone metastases who underwent both 68 Ga-FAPI PET/CT and 18FDGPET/CT within a 1 week period were included in this retrospective study. The effect of the SUVmax value of bone lesions on overall survival was analyzed.
Results
A total of 75 eligible patients with 139 bone lesions were included in this study. The median age of the patients was 55 (30–83) and 48(64%) patients were newly diagnosed. The primary lesion median 68 Ga-FAPI PET/CT SUVmax value was higher than the median 18FDGPET/CT SUVmax (10.75 versus 6.7). Bone lesions 68 Ga-FAPI PET/CT SUVmax median (IQR) were 7.8 (4.6–13.2), and 18FDGPET/CT SUVmax of bone lesions were 5.9 (3.8–8.2). More bone lesions were detected on 68 Ga-FAPI PET/CT than on 18FDGPET/CT(median IQR 4 [1–9] versus 2 [1–6] (p = 0.014). The extra lesions observed on 68 Ga-FAPI PET/CT were mostly sclerotic bone lesions (p = 0.001).68 Ga-FAPI PET/CT SUVmax was significantly higher in vertebra and thorax lesions (p = 0.011 and p = 0.018, respectively). While the bone lesion 68 Ga-FAPI PET/CT SUVmax affected the OS, the 18FDGPET/CT SUVmax value did not affect the OS (p < 0.001 and p = 0.079, respectively). In ROC analysis, a cut-off-off value of 68 Ga-FAPI PET/CT SUVmax > 7.7 was found for OS (AUC: 0.619). The median OS in the group above the cut-off value was worse than that in the group below the cut-off value (32 versus 45) months (p = 0.002). In the multivariate analysis for OS, the 68 Ga-FAPI PET/CT SUVmax of bone lesions was an important parameter, as well as cancer subtype, ALP level, and disease occurrence.
Conclusions
68 Ga-FAPI PET/CT detected more bone lesions and higher SUVmax values than 18FDGPET/CT in various cancers. The prognostic value of the SUVmax value of 68 Ga-FAPI PET/CT bone lesions was observed regardless of disease subtype.
期刊介绍：
Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine.
The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
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