Shi-Yan Feng, Na Jiang, Jia-Ying Yang, Lin-Yao Yang, Jiang-Chao Du, Xuan-Qin Chen, Dan Liu, Rong-Tao Li, Jin-Dong Zhong
{"title":"Mosla chinensis Maxim 树枝中化学成分的抗病毒和抗炎活性","authors":"Shi-Yan Feng, Na Jiang, Jia-Ying Yang, Lin-Yao Yang, Jiang-Chao Du, Xuan-Qin Chen, Dan Liu, Rong-Tao Li, Jin-Dong Zhong","doi":"10.1007/s13659-024-00448-w","DOIUrl":null,"url":null,"abstract":"<div><p>Seven undescribed compounds, including three flavones (<b>1–3</b>), one phenylpropanoid (<b>19</b>), three monoaromatic hydrocarbons (<b>27–29</b>), were isolated from the twigs of <i>Mosla chinensis</i> Maxim together with twenty-eight known compounds. The structures were characterized by HRESIMS, 1D and 2D NMR, and ECD spectroscopic techniques. Compound <b>20</b> displayed the most significant activity against A/WSN/33/2009 (H1N1) virus (IC<sub>50</sub> = 20.47 <i>μ</i>M) compared to the positive control oseltamivir (IC<sub>50</sub> = 6.85 <i>µ</i>M). Further research on the anti-influenza mechanism showed that compound <b>20</b> could bind to H1N1 virus surface antigen HA1 and inhibit the early attachment stage of the virus. Furthermore, compounds <b>9</b>, <b>22</b>, <b>23</b>, and <b>25</b> displayed moderate inhibitory effects on the NO expression in LPS inducing Raw 264.7 cells with IC<sub>50</sub> values of 22.78, 20.47, 27.66, and 30.14 <i>µ</i>M, respectively.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":null,"pages":null},"PeriodicalIF":4.8000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00448-w.pdf","citationCount":"0","resultStr":"{\"title\":\"Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim\",\"authors\":\"Shi-Yan Feng, Na Jiang, Jia-Ying Yang, Lin-Yao Yang, Jiang-Chao Du, Xuan-Qin Chen, Dan Liu, Rong-Tao Li, Jin-Dong Zhong\",\"doi\":\"10.1007/s13659-024-00448-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Seven undescribed compounds, including three flavones (<b>1–3</b>), one phenylpropanoid (<b>19</b>), three monoaromatic hydrocarbons (<b>27–29</b>), were isolated from the twigs of <i>Mosla chinensis</i> Maxim together with twenty-eight known compounds. The structures were characterized by HRESIMS, 1D and 2D NMR, and ECD spectroscopic techniques. Compound <b>20</b> displayed the most significant activity against A/WSN/33/2009 (H1N1) virus (IC<sub>50</sub> = 20.47 <i>μ</i>M) compared to the positive control oseltamivir (IC<sub>50</sub> = 6.85 <i>µ</i>M). Further research on the anti-influenza mechanism showed that compound <b>20</b> could bind to H1N1 virus surface antigen HA1 and inhibit the early attachment stage of the virus. Furthermore, compounds <b>9</b>, <b>22</b>, <b>23</b>, and <b>25</b> displayed moderate inhibitory effects on the NO expression in LPS inducing Raw 264.7 cells with IC<sub>50</sub> values of 22.78, 20.47, 27.66, and 30.14 <i>µ</i>M, respectively.</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":718,\"journal\":{\"name\":\"Natural Products and Bioprospecting\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s13659-024-00448-w.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Products and Bioprospecting\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13659-024-00448-w\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Products and Bioprospecting","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s13659-024-00448-w","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim
Seven undescribed compounds, including three flavones (1–3), one phenylpropanoid (19), three monoaromatic hydrocarbons (27–29), were isolated from the twigs of Mosla chinensis Maxim together with twenty-eight known compounds. The structures were characterized by HRESIMS, 1D and 2D NMR, and ECD spectroscopic techniques. Compound 20 displayed the most significant activity against A/WSN/33/2009 (H1N1) virus (IC50 = 20.47 μM) compared to the positive control oseltamivir (IC50 = 6.85 µM). Further research on the anti-influenza mechanism showed that compound 20 could bind to H1N1 virus surface antigen HA1 and inhibit the early attachment stage of the virus. Furthermore, compounds 9, 22, 23, and 25 displayed moderate inhibitory effects on the NO expression in LPS inducing Raw 264.7 cells with IC50 values of 22.78, 20.47, 27.66, and 30.14 µM, respectively.
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