Shi-Yan Feng, Na Jiang, Jia-Ying Yang, Lin-Yao Yang, Jiang-Chao Du, Xuan-Qin Chen, Dan Liu, Rong-Tao Li, Jin-Dong Zhong
{"title":"Mosla chinensis Maxim 树枝中化学成分的抗病毒和抗炎活性","authors":"Shi-Yan Feng, Na Jiang, Jia-Ying Yang, Lin-Yao Yang, Jiang-Chao Du, Xuan-Qin Chen, Dan Liu, Rong-Tao Li, Jin-Dong Zhong","doi":"10.1007/s13659-024-00448-w","DOIUrl":null,"url":null,"abstract":"<div><p>Seven undescribed compounds, including three flavones (<b>1–3</b>), one phenylpropanoid (<b>19</b>), three monoaromatic hydrocarbons (<b>27–29</b>), were isolated from the twigs of <i>Mosla chinensis</i> Maxim together with twenty-eight known compounds. The structures were characterized by HRESIMS, 1D and 2D NMR, and ECD spectroscopic techniques. Compound <b>20</b> displayed the most significant activity against A/WSN/33/2009 (H1N1) virus (IC<sub>50</sub> = 20.47 <i>μ</i>M) compared to the positive control oseltamivir (IC<sub>50</sub> = 6.85 <i>µ</i>M). Further research on the anti-influenza mechanism showed that compound <b>20</b> could bind to H1N1 virus surface antigen HA1 and inhibit the early attachment stage of the virus. Furthermore, compounds <b>9</b>, <b>22</b>, <b>23</b>, and <b>25</b> displayed moderate inhibitory effects on the NO expression in LPS inducing Raw 264.7 cells with IC<sub>50</sub> values of 22.78, 20.47, 27.66, and 30.14 <i>µ</i>M, respectively.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00448-w.pdf","citationCount":"0","resultStr":"{\"title\":\"Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim\",\"authors\":\"Shi-Yan Feng, Na Jiang, Jia-Ying Yang, Lin-Yao Yang, Jiang-Chao Du, Xuan-Qin Chen, Dan Liu, Rong-Tao Li, Jin-Dong Zhong\",\"doi\":\"10.1007/s13659-024-00448-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Seven undescribed compounds, including three flavones (<b>1–3</b>), one phenylpropanoid (<b>19</b>), three monoaromatic hydrocarbons (<b>27–29</b>), were isolated from the twigs of <i>Mosla chinensis</i> Maxim together with twenty-eight known compounds. The structures were characterized by HRESIMS, 1D and 2D NMR, and ECD spectroscopic techniques. Compound <b>20</b> displayed the most significant activity against A/WSN/33/2009 (H1N1) virus (IC<sub>50</sub> = 20.47 <i>μ</i>M) compared to the positive control oseltamivir (IC<sub>50</sub> = 6.85 <i>µ</i>M). Further research on the anti-influenza mechanism showed that compound <b>20</b> could bind to H1N1 virus surface antigen HA1 and inhibit the early attachment stage of the virus. Furthermore, compounds <b>9</b>, <b>22</b>, <b>23</b>, and <b>25</b> displayed moderate inhibitory effects on the NO expression in LPS inducing Raw 264.7 cells with IC<sub>50</sub> values of 22.78, 20.47, 27.66, and 30.14 <i>µ</i>M, respectively.</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":718,\"journal\":{\"name\":\"Natural Products and Bioprospecting\",\"volume\":\"14 1\",\"pages\":\"\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s13659-024-00448-w.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Products and Bioprospecting\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13659-024-00448-w\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Products and Bioprospecting","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s13659-024-00448-w","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim
Seven undescribed compounds, including three flavones (1–3), one phenylpropanoid (19), three monoaromatic hydrocarbons (27–29), were isolated from the twigs of Mosla chinensis Maxim together with twenty-eight known compounds. The structures were characterized by HRESIMS, 1D and 2D NMR, and ECD spectroscopic techniques. Compound 20 displayed the most significant activity against A/WSN/33/2009 (H1N1) virus (IC50 = 20.47 μM) compared to the positive control oseltamivir (IC50 = 6.85 µM). Further research on the anti-influenza mechanism showed that compound 20 could bind to H1N1 virus surface antigen HA1 and inhibit the early attachment stage of the virus. Furthermore, compounds 9, 22, 23, and 25 displayed moderate inhibitory effects on the NO expression in LPS inducing Raw 264.7 cells with IC50 values of 22.78, 20.47, 27.66, and 30.14 µM, respectively.
期刊介绍:
Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects:
Natural products: isolation and structure elucidation
Natural products: synthesis
Biological evaluation of biologically active natural products
Bioorganic and medicinal chemistry
Biosynthesis and microbiological transformation
Fermentation and plant tissue cultures
Bioprospecting of natural products from natural resources
All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.