创伤性脊髓损伤的病理生物学:概述

IF 0.7 Q4 CLINICAL NEUROLOGY Egyptian journal of neurosurgery Pub Date : 2024-05-02 DOI:10.1186/s41984-024-00282-9
William A. Florez-Perdomo, Andrés Cardona-Cruz Guillermo, Ezequiel García-Ballestas, Abigail Castilla-Martínez, Yancarlos Ramos-Villegas, Loraine Quintana-Pájaro, Tariq Janjua, Amit Agrawal, Luis Rafael Moscote-Salazar
{"title":"创伤性脊髓损伤的病理生物学:概述","authors":"William A. Florez-Perdomo, Andrés Cardona-Cruz Guillermo, Ezequiel García-Ballestas, Abigail Castilla-Martínez, Yancarlos Ramos-Villegas, Loraine Quintana-Pájaro, Tariq Janjua, Amit Agrawal, Luis Rafael Moscote-Salazar","doi":"10.1186/s41984-024-00282-9","DOIUrl":null,"url":null,"abstract":"Traumatic spinal cord injury (SCI) or traumatic myelopathy is a devastating neurological condition and a heavy burden on the health system. There are inflammatory and structural biomarkers with well-defined profiles, and useful for determining the management and prognosis of this pathology. Laboratory studies have shown some utility in confirming the existence of a spinal cord injury. Little knowledge about the molecular processes that occur after a SCI is evident, and it is well known that its understanding is dispensable to establish therapeutic targets that improve the outcomes for this type of patient. Many studies have explored the role of structural and inflammatory markers and some structural and inflammatory biomarkers. In the present article, we review the ongoing research in the field of spinal injury and possible role of biomarkers in the management of these patients.","PeriodicalId":72881,"journal":{"name":"Egyptian journal of neurosurgery","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pathobiology of traumatic spinal cord injury: an overview\",\"authors\":\"William A. Florez-Perdomo, Andrés Cardona-Cruz Guillermo, Ezequiel García-Ballestas, Abigail Castilla-Martínez, Yancarlos Ramos-Villegas, Loraine Quintana-Pájaro, Tariq Janjua, Amit Agrawal, Luis Rafael Moscote-Salazar\",\"doi\":\"10.1186/s41984-024-00282-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Traumatic spinal cord injury (SCI) or traumatic myelopathy is a devastating neurological condition and a heavy burden on the health system. There are inflammatory and structural biomarkers with well-defined profiles, and useful for determining the management and prognosis of this pathology. Laboratory studies have shown some utility in confirming the existence of a spinal cord injury. Little knowledge about the molecular processes that occur after a SCI is evident, and it is well known that its understanding is dispensable to establish therapeutic targets that improve the outcomes for this type of patient. Many studies have explored the role of structural and inflammatory markers and some structural and inflammatory biomarkers. In the present article, we review the ongoing research in the field of spinal injury and possible role of biomarkers in the management of these patients.\",\"PeriodicalId\":72881,\"journal\":{\"name\":\"Egyptian journal of neurosurgery\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-05-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Egyptian journal of neurosurgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s41984-024-00282-9\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Egyptian journal of neurosurgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s41984-024-00282-9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

创伤性脊髓损伤(SCI)或创伤性脊髓病是一种破坏性神经系统疾病,给医疗系统带来沉重负担。有一些炎症和结构生物标志物具有明确的特征,有助于确定这种病症的管理和预后。实验室研究在确认脊髓损伤的存在方面显示出一定的作用。人们对脊髓损伤后发生的分子过程显然知之甚少,众所周知,要确定治疗目标以改善这类患者的预后,对分子过程的了解是必不可少的。许多研究都探讨了结构和炎症标志物以及一些结构和炎症生物标志物的作用。在本文中,我们回顾了脊柱损伤领域正在进行的研究以及生物标志物在这些患者的治疗中可能发挥的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Pathobiology of traumatic spinal cord injury: an overview
Traumatic spinal cord injury (SCI) or traumatic myelopathy is a devastating neurological condition and a heavy burden on the health system. There are inflammatory and structural biomarkers with well-defined profiles, and useful for determining the management and prognosis of this pathology. Laboratory studies have shown some utility in confirming the existence of a spinal cord injury. Little knowledge about the molecular processes that occur after a SCI is evident, and it is well known that its understanding is dispensable to establish therapeutic targets that improve the outcomes for this type of patient. Many studies have explored the role of structural and inflammatory markers and some structural and inflammatory biomarkers. In the present article, we review the ongoing research in the field of spinal injury and possible role of biomarkers in the management of these patients.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
审稿时长
32 weeks
期刊最新文献
Multidisciplinary team approach in management of anterior spinal dysraphism with unusual presentation: case series and surgical approach Analysis of moderate and severe traumatic brain injury associated with skull base fracture: a local tertiary center experience Conventional and old endovascular techniques for vertebral aneurysms still work in the era of flow diversion Possible effects of lumbar stabilization surgery on sagittal alignment, disability and quality of life Role of intraoperative cranial ultrasonography in detection of residual brain lesions during surgery
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1