肌肉骨骼系统中的泛内联蛋白:发展和疾病进展的新目标

IF 14.3 1区 医学 Q1 CELL & TISSUE ENGINEERING Bone Research Pub Date : 2024-05-06 DOI:10.1038/s41413-024-00334-8
Yan Luo, Shengyuan Zheng, Wenfeng Xiao, Hang Zhang, Yusheng Li
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引用次数: 0

摘要

在细胞分化、生长和发育过程中,细胞可通过通讯通道对细胞外的刺激做出反应。Pannexin(Panx)家族和 connexin(Cx)家族是两种重要的通道形成蛋白。Panx 家族包含三个成员(Panx1-3),在骨骼、软骨和肌肉中广泛表达。虽然 Panx 家族与 Cx 家族之间没有序列同源性,但它们具有相似的结构和功能。与 Cxs 类似,Panxs 在维持肌肉骨骼系统生理功能和疾病进展中的关键作用也在后来逐渐被揭示。在此,我们试图阐明 Panxs 的结构及其在调控骨生成、软骨生成和肌肉生长等过程中的作用。我们还关注了 Cx 和 Panx 之间的比较。作为一个新的关键靶点,我们还讨论了 Panxs 在肌肉中的表达失衡和功能障碍,以及 Panxs 在关节疾病中的治疗潜力。
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Pannexins in the musculoskeletal system: new targets for development and disease progression

During cell differentiation, growth, and development, cells can respond to extracellular stimuli through communication channels. Pannexin (Panx) family and connexin (Cx) family are two important types of channel-forming proteins. Panx family contains three members (Panx1-3) and is expressed widely in bone, cartilage and muscle. Although there is no sequence homology between Panx family and Cx family, they exhibit similar configurations and functions. Similar to Cxs, the key roles of Panxs in the maintenance of physiological functions of the musculoskeletal system and disease progression were gradually revealed later. Here, we seek to elucidate the structure of Panxs and their roles in regulating processes such as osteogenesis, chondrogenesis, and muscle growth. We also focus on the comparison between Cx and Panx. As a new key target, Panxs expression imbalance and dysfunction in muscle and the therapeutic potentials of Panxs in joint diseases are also discussed.

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来源期刊
Bone Research
Bone Research CELL & TISSUE ENGINEERING-
CiteScore
20.00
自引率
4.70%
发文量
289
审稿时长
20 weeks
期刊介绍: Established in 2013, Bone Research is a newly-founded English-language periodical that centers on the basic and clinical facets of bone biology, pathophysiology, and regeneration. It is dedicated to championing key findings emerging from both basic investigations and clinical research concerning bone-related topics. The journal's objective is to globally disseminate research in bone-related physiology, pathology, diseases, and treatment, contributing to the advancement of knowledge in this field.
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