Satish Chaudhary, Reetesh Sharma, Saumya Gupta, Sita Paikra, Mohit Gupta, Bal K Upadhyay, Alok Sharma, Rajiv K Sethia
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Successful Reversal of Refractory Posttransplant Thrombotic Microangiopathy with Eculizumab.
Posttransplant thrombotic microangiopathy (PT-TMA) can be caused by calcineurin inhibitors (CNIs), ischemic injury, infections, or antibody-mediated rejection (ABMR). Delayed recognition can result in allograft loss. We describe the first reported case of successful reversal of refractory PT-TMA with eculizumab in India. It highlights the importance of prompt diagnosis and benefit from an early initiation of eculizumab therapy in refractory cases.
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