铁蛋白沉积症与炎症性肠病的研究进展。

IF 4.1 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biometals Pub Date : 2024-05-07 DOI:10.1007/s10534-024-00604-2
Baolian Ma, Xiaoxue Hu, Xiaowen Ai, Yonglan Zhang
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引用次数: 0

摘要

炎症性肠病(IBD)是一种非特异性的慢性胃肠道炎症性疾病,给社会和个人都带来了沉重的负担。作为一种新型的调控细胞死亡(RCD),铁变态反应在细胞形态、生物化学和遗传学等方面都有别于细胞凋亡和坏死等经典RCD。铁变态反应的主要分子机制包括铁代谢失调、抗氧化能力受损、线粒体功能障碍、脂质相关超级氧化物积累和膜破坏。近年来,越来越多的证据表明,铁变态反应与炎症性肠病的病理生理学有关。然而,其确切作用和潜在的分子机制尚未完全阐明。本文回顾了铁蛋白沉积在炎症性肠病发生和发展过程中的作用机制,以期为炎症性肠病的病理生理学研究提供新思路。此外,我们还讨论了通过靶向铁蛋白沉积来预防和治疗炎症性肠病的潜在策略。
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Research progress of ferroptosis and inflammatory bowel disease

Inflammatory bowel disease (IBD) is a non-specific chronic inflammatory disorder of the gastrointestinal tract, imposing significant burdens on both society and individuals. As a new type of regulated cell death (RCD), ferroptosis is different from classic RCDs such as apoptosis and necrosis in cell morphology, biochemistry and genetics. The main molecular mechanisms of ferroptosis include dysregulation of iron metabolism, impaired antioxidant capacity, mitochondrial dysfunction, accumulation of lipid-associated super-oxides, and membrane disruption. In recent years, increasing evidence has shown that ferroptosis is involved in the pathophysiology of inflammatory bowel disease. However, the exact roles and underlying molecular mechanisms have not been fully elucidated. This article reviews the mechanism of ferroptosis in the occurrence and development of inflammatory bowel disease, in order to provide new ideas for the pathophysiological research of inflammatory bowel disease. Additionally, we discuss potential strategies for the prevention and treatment of inflammatory bowel disease by targeting ferroptosis.

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来源期刊
Biometals
Biometals 生物-生化与分子生物学
CiteScore
5.90
自引率
8.60%
发文量
111
审稿时长
3 months
期刊介绍: BioMetals is the only established journal to feature the important role of metal ions in chemistry, biology, biochemistry, environmental science, and medicine. BioMetals is an international, multidisciplinary journal singularly devoted to the rapid publication of the fundamental advances of both basic and applied research in this field. BioMetals offers a forum for innovative research and clinical results on the structure and function of: - metal ions - metal chelates, - siderophores, - metal-containing proteins - biominerals in all biosystems. - BioMetals rapidly publishes original articles and reviews. BioMetals is a journal for metals researchers who practice in medicine, biochemistry, pharmacology, toxicology, microbiology, cell biology, chemistry, and plant physiology who are based academic, industrial and government laboratories.
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