干细胞衍生的外泌体微RNA是治疗多发性硬化症的潜在新方法

IF 3.6 4区 医学 Q3 CELL BIOLOGY Cellular and Molecular Neurobiology Pub Date : 2024-05-07 DOI:10.1007/s10571-024-01478-1
Fatemeh Tahmasebi, Elmira Roshani Asl, Zeinab Vahidinia, Shirin Barati
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引用次数: 0

摘要

多发性硬化症(MS)是一种以中枢神经系统(CNS)神经元炎症和脱髓鞘为特征的中枢神经系统自身免疫性疾病。迄今为止,针对多发性硬化症有许多治疗策略,但这些策略只能减少疾病的进展,对修复和再髓鞘化没有任何效果。干细胞疗法是一种合适的再生方法,但也存在局限性和问题。因此,最近的研究使用了外泌体,它能促进细胞间的交流并传递细胞间的生物信息。微小核糖核酸(miRNA)是一类短的非编码核糖核酸,我们可以利用它们的失调来诊断疾病。获得干细胞的微囊泡中的 miRNA 可根据接收到的损伤区域信号改变移植细胞的命运。间充质干细胞中的 miRNA 可显示细胞类型及其生物活性。目前的研究还表明,miRNA 在干细胞和组织损伤细胞之间建立了沟通。在本综述中,我们首先讨论了miRNAs失调在多发性硬化症患者中的作用以及干细胞中miRNAs的表达。最后,本研究证实了参与多发性硬化症的miRNAs与干细胞表达的miRNAs之间的关系,以及它们之间的相互作用,以便在未来找到适当的治疗方法,限制残疾的进展。
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Stem Cell-Derived Exosomal MicroRNAs as Novel Potential Approach for Multiple Sclerosis Treatment.

Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized by inflammation and demyelination of CNS neurons. Up to now, there are many therapeutic strategies for MS but they are only being able to reduce progression of diseases and have not got any effect on repair and remyelination. Stem cell therapy is an appropriate method for regeneration but has limitations and problems. So recently, researches were used of exosomes that facilitate intercellular communication and transfer cell-to-cell biological information. MicroRNAs (miRNAs) are a class of short non-coding RNAs that we can used to their dysregulation in order to diseases diagnosis. The miRNAs of microvesicles obtained stem cells may change the fate of transplanted cells based on received signals of injured regions. The miRNAs existing in MSCs may be displayed the cell type and their biological activities. Current studies show also that the miRNAs create communication between stem cells and tissue-injured cells. In the present review, firstly we discuss the role of miRNAs dysregulation in MS patients and miRNAs expression by stem cells. Finally, in this study was confirmed the relationship of microRNAs involved in MS and miRNAs expressed by stem cells and interaction between them in order to find appropriate treatment methods in future for limit to disability progression.

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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.
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