{"title":"当前针对鲍曼不动杆菌毒力因子和生物膜形成的治疗策略。","authors":"Seetha Lakshmi Rajangam, Manoj Kumar Narasimhan","doi":"10.2217/fmb-2023-0263","DOIUrl":null,"url":null,"abstract":"<p><p>A higher prevalence of <i>Acinetobacter baumannii</i> infections and mortality rate has been reported recently in hospital-acquired infections (HAI). The biofilm-forming capability of <i>A. baumannii</i> makes it an extremely dangerous pathogen, especially in device-associated hospital-acquired infections (DA-HAI), thereby it resists the penetration of antibiotics. Further, the transmission of the SARS-CoV-2 virus was exacerbated in DA-HAI during the epidemic. This review specifically examines the complex interconnections between several components and genes that play a role in the biofilm formation and the development of infections. The current review provides insights into innovative treatments and therapeutic approaches to combat <i>A. baumannii</i> biofilm-related infections, thereby ultimately improving patient outcomes and reducing the burden of HAI.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290764/pdf/","citationCount":"0","resultStr":"{\"title\":\"Current treatment strategies for targeting virulence factors and biofilm formation in <i>Acinetobacter baumannii</i>.\",\"authors\":\"Seetha Lakshmi Rajangam, Manoj Kumar Narasimhan\",\"doi\":\"10.2217/fmb-2023-0263\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A higher prevalence of <i>Acinetobacter baumannii</i> infections and mortality rate has been reported recently in hospital-acquired infections (HAI). The biofilm-forming capability of <i>A. baumannii</i> makes it an extremely dangerous pathogen, especially in device-associated hospital-acquired infections (DA-HAI), thereby it resists the penetration of antibiotics. Further, the transmission of the SARS-CoV-2 virus was exacerbated in DA-HAI during the epidemic. This review specifically examines the complex interconnections between several components and genes that play a role in the biofilm formation and the development of infections. The current review provides insights into innovative treatments and therapeutic approaches to combat <i>A. baumannii</i> biofilm-related infections, thereby ultimately improving patient outcomes and reducing the burden of HAI.</p>\",\"PeriodicalId\":12773,\"journal\":{\"name\":\"Future microbiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-07-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290764/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Future microbiology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.2217/fmb-2023-0263\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/4/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.2217/fmb-2023-0263","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/4/29 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
据报道，最近在医院获得性感染（HAI）中，鲍曼不动杆菌的感染率和死亡率都有所上升。鲍曼不动杆菌的生物膜形成能力使其成为一种极其危险的病原体，尤其是在与设备相关的医院获得性感染（DA-HAI）中，因此它能抵抗抗生素的渗透。此外，在疫情期间，SARS-CoV-2 病毒的传播在 DA-HAI 中加剧。本综述特别探讨了在生物膜形成和感染发展过程中发挥作用的多个成分和基因之间复杂的相互联系。本综述深入探讨了抗击鲍曼不动杆菌生物膜相关感染的创新疗法和治疗方法，从而最终改善患者预后并减轻 HAI 负担。
Current treatment strategies for targeting virulence factors and biofilm formation in Acinetobacter baumannii.
A higher prevalence of Acinetobacter baumannii infections and mortality rate has been reported recently in hospital-acquired infections (HAI). The biofilm-forming capability of A. baumannii makes it an extremely dangerous pathogen, especially in device-associated hospital-acquired infections (DA-HAI), thereby it resists the penetration of antibiotics. Further, the transmission of the SARS-CoV-2 virus was exacerbated in DA-HAI during the epidemic. This review specifically examines the complex interconnections between several components and genes that play a role in the biofilm formation and the development of infections. The current review provides insights into innovative treatments and therapeutic approaches to combat A. baumannii biofilm-related infections, thereby ultimately improving patient outcomes and reducing the burden of HAI.
期刊介绍：
Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.
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