Haijiao Wang, Ge Tan, Xiuli Li, Deng Chen, Dongmei An, Qiyong Gong, Ling Liu
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The amplitudes of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) were used to measure local functional activity, and voxel-wise degree centrality (DC) and seed-based functional connectivity (FC) were used to evaluate the connecting intensity of the brain areas.</p><p><strong>Results: </strong>Compared to the HC and WC groups, the UC group had higher ALFF values in the left posterior central gyrus (PoCG.L) and left inferior temporal gyrus (ITG.L) and higher DC in the bilateral PoCG (Gaussian random field correction, voxel-level P < 0.001, and cluster-level P < 0.05). 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引用次数: 0
摘要
目的分析与药物反应相关的新诊断癫痫患者（NDE）的大脑局部功能活动和连接特征：招募的患者在基线时接受功能磁共振成像检查，并根据他们对抗癫痫药物的反应被分配到控制良好组（WC，28 人）或未控制组（UC，11 人）。健康参与者被纳入对照组（HC，n = 29）。低频波动振幅（ALFF）和分数 ALFF（fALFF）用于测量局部功能活动，体素度中心性（DC）和基于种子的功能连接性（FC）用于评估脑区的连接强度：结果：与 HC 组和 WC 组相比，UC 组左侧中央后回（PoCG.L）和左侧颞下回（ITG.L）的 ALFF 值更高，双侧 PoCG 的 DC 值更高（高斯随机场校正，体素水平 P 解释）：在 ASM 试验无效的 NDE 患者中，大脑功能活动或连接强度的过度增强可能与药物反应不佳的风险较高有关。
Aberrant functional connectivity associated with drug response in patients with newly diagnosed epilepsy.
Objective: To analyze the local functional activity and connectivity features of the brain associated with drug response inpatients newly diagnosed with epilepsy (NDE) who are naïve to anti-seizure medication (ASM).
Methods: Recruited patients, underwent functional magnetic resonance imaging at baseline, and were assigned to the well-controlled (WC, n = 28) or uncontrolled (UC, n = 11) groups based on their response to ASM. Healthy participants were included in the control group (HC, n = 29). The amplitudes of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) were used to measure local functional activity, and voxel-wise degree centrality (DC) and seed-based functional connectivity (FC) were used to evaluate the connecting intensity of the brain areas.
Results: Compared to the HC and WC groups, the UC group had higher ALFF values in the left posterior central gyrus (PoCG.L) and left inferior temporal gyrus (ITG.L) and higher DC in the bilateral PoCG (Gaussian random field correction, voxel-level P < 0.001, and cluster-level P < 0.05). Both PoCG and ITG.L in the UC group showed stronger FC with multiple brain regions, mainly located in the occipital and temporal lobes, compared to the HC or WC group, while the WC group showed decreased or similar FC compared to the HC group.
Interpretation: Excessive enhancement of brain functional activity or connecting intensity in ASM-naïve patients with NDE may be associated with a higher risk of poor drug response.
期刊介绍：
Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.
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