Pub Date : 2026-02-09DOI: 10.1007/s10072-026-08874-z
Karim Mohamed, Mingqiang Ren, Nyamkhishig Sambuughin, Francis G O'Connor, Peter Finnigan, Ros Quinlivan
{"title":"Acute rhabdomyolysis as the presenting symptom in two females with a DMD mutation.","authors":"Karim Mohamed, Mingqiang Ren, Nyamkhishig Sambuughin, Francis G O'Connor, Peter Finnigan, Ros Quinlivan","doi":"10.1007/s10072-026-08874-z","DOIUrl":"https://doi.org/10.1007/s10072-026-08874-z","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"246"},"PeriodicalIF":2.4,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-09DOI: 10.1007/s10072-026-08837-4
Wen Zhao, Jinyu Shi, Anand Karthik Sarma, Jianwen Lin, Cui Wang, Lushuang Xie, Yi Liu
Background: Multiple system atrophy (MSA) is a neurodegenerative disease that affects the extrapyramidal, cerebellar, and autonomic nervous systems. In some patients, hypothalamic involvement can lead to impaired thermoregulation and hyponatremia. Duloxetine, a serotonin-norepinephrine reuptake inhibitor used for chronic pain, has rarely been linked to fever and syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Case presentation: A 66-year-old man with clinically probable MSA and baseline hyponatremia (serum sodium 121.6 mmol/L) started duloxetine 30 mg/day for migrating pain. Within 24 h, he developed high fever (38.0-39.5 °C) without sweating, and serum sodium fell to 117 mmol/L despite oral sodium supplementation. Findings supported SIADH, with low plasma osmolality (269 mOsm/kg), inappropriately concentrated urine (404 mOsm/kg), and high 24-h urinary sodium (444.5 mmol). The infectious workup was largely unremarkable, and antibiotics did not improve either fever or hyponatremia. After duloxetine was discontinued, body temperature gradually returned to normal, sweating resumed, and serum sodium increased. He later developed aspiration-related pneumonia and died despite intensive care.
Conclusions: Duloxetine may trigger fever and worsen hyponatremia due to SIADH in patients with MSA, possibly by increasing hypothalamic stress. Duloxetine should be used cautiously in MSA, with close monitoring of temperature and serum sodium, particularly in patients with pre-existing hyponatremia or suspected hypothalamic involvement.
{"title":"Fever and syndrome of inappropriate antidiuretic hormone secretion in a patient with multiple system atrophy after treatment with duloxetine.","authors":"Wen Zhao, Jinyu Shi, Anand Karthik Sarma, Jianwen Lin, Cui Wang, Lushuang Xie, Yi Liu","doi":"10.1007/s10072-026-08837-4","DOIUrl":"https://doi.org/10.1007/s10072-026-08837-4","url":null,"abstract":"<p><strong>Background: </strong>Multiple system atrophy (MSA) is a neurodegenerative disease that affects the extrapyramidal, cerebellar, and autonomic nervous systems. In some patients, hypothalamic involvement can lead to impaired thermoregulation and hyponatremia. Duloxetine, a serotonin-norepinephrine reuptake inhibitor used for chronic pain, has rarely been linked to fever and syndrome of inappropriate antidiuretic hormone secretion (SIADH).</p><p><strong>Case presentation: </strong>A 66-year-old man with clinically probable MSA and baseline hyponatremia (serum sodium 121.6 mmol/L) started duloxetine 30 mg/day for migrating pain. Within 24 h, he developed high fever (38.0-39.5 °C) without sweating, and serum sodium fell to 117 mmol/L despite oral sodium supplementation. Findings supported SIADH, with low plasma osmolality (269 mOsm/kg), inappropriately concentrated urine (404 mOsm/kg), and high 24-h urinary sodium (444.5 mmol). The infectious workup was largely unremarkable, and antibiotics did not improve either fever or hyponatremia. After duloxetine was discontinued, body temperature gradually returned to normal, sweating resumed, and serum sodium increased. He later developed aspiration-related pneumonia and died despite intensive care.</p><p><strong>Conclusions: </strong>Duloxetine may trigger fever and worsen hyponatremia due to SIADH in patients with MSA, possibly by increasing hypothalamic stress. Duloxetine should be used cautiously in MSA, with close monitoring of temperature and serum sodium, particularly in patients with pre-existing hyponatremia or suspected hypothalamic involvement.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"244"},"PeriodicalIF":2.4,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-09DOI: 10.1007/s10072-026-08845-4
Shule Wang, Heng Wang, Gamal Musleh, Wenyi Chu
{"title":"Temperature fluctuations and genetic influences on Parkinson's disease: a comprehensive analysis of temperature variability and time spent outdoors in the United States (1999-2023).","authors":"Shule Wang, Heng Wang, Gamal Musleh, Wenyi Chu","doi":"10.1007/s10072-026-08845-4","DOIUrl":"https://doi.org/10.1007/s10072-026-08845-4","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"245"},"PeriodicalIF":2.4,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-07DOI: 10.1007/s10072-026-08847-2
Francesco Brigo, Arian Zaboli, Elisabetta Maida, Luigi Lavorgna
{"title":"AI for clinical neurology: Comparing five large language models in neurological diagnosis and lesion localization.","authors":"Francesco Brigo, Arian Zaboli, Elisabetta Maida, Luigi Lavorgna","doi":"10.1007/s10072-026-08847-2","DOIUrl":"https://doi.org/10.1007/s10072-026-08847-2","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"242"},"PeriodicalIF":2.4,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146132452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-07DOI: 10.1007/s10072-026-08880-1
Rosalba Rosato, Andrea Giordano, Beatrice Biolzi, Clara Grazia Chisari, Monica Falautano, Monica Grobberio, Claudia Niccolai, Erika Pietrolongo, Maria Esmeralda Quartuccio, Rosa Gemma Viterbo, Antonella Delle Fave, Marta Bassi
{"title":"Correction to: Assessing validity and reliability of the Benefit Finding Scale in Italian people with multiple sclerosis and their caregivers.","authors":"Rosalba Rosato, Andrea Giordano, Beatrice Biolzi, Clara Grazia Chisari, Monica Falautano, Monica Grobberio, Claudia Niccolai, Erika Pietrolongo, Maria Esmeralda Quartuccio, Rosa Gemma Viterbo, Antonella Delle Fave, Marta Bassi","doi":"10.1007/s10072-026-08880-1","DOIUrl":"10.1007/s10072-026-08880-1","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"243"},"PeriodicalIF":2.4,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12880986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146132450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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