Xiuyun Chen, Siping Sun, Hong Chen, Xiuyun Sun, Aichun Yang, Qing Wang, Bin Shi
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Twelve articles were selected as most relevant to this review; 10 were in Chinese, and 2 were in English.</p><p><strong>Results: </strong>The results showed that the incidence of asthenia in COPD patients was 26% (OR 0.26, 95% CI 0.17~0.34).</p><p><strong>Discussion: </strong>The main risk factors for frailty in COPD patients were age (OR 1.32, 95% CI 1.30~1.34), GOLD pulmonary function class (OR 3.18, 95% CI 2.14~4.71), mMRC score (OR 3.90, 95% CI 1.53~9.92), comorbidity (OR 2.17, 95% CI 1.48~3.18), polypharmacy (OR 6.74, 95% CI 3.23~14.08), malnutrition (OR 3.32, 95% CI 1.77~6.24), depression (OR 1.37, 95% CI 1.07~1.76) and ≥2 admissions within 1 year (OR 4.84, 95% CI 2.45~9.57).</p><p><strong>Conclusion: </strong>The study presented comprehensive evidence through meta-analysis and proposed that the prevalence of frailty in COPD patients is 26%. Risk factors were identified, including age, pulmonary function class according to GOLD criteria, mMRC score, comorbidity polypharmacy malnutrition, depression, or 2 or more hospital admissions within a year. 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引用次数: 0
摘要
目的：慢性阻塞性肺病（COPD）患者体弱发生率高，并发症多，严重影响患者的生活质量。本研究系统评估和分析了慢性阻塞性肺病患者的虚弱发生率和风险因素现状，以降低患者的虚弱发生率，提高其生活质量：方法：在Cochrane Library、PubMed、Embase、Web of Science、CBM、CNKI、VIP和万方数据库中检索了自各数据库建立以来至2022年11月的相关研究。进行了全面的文献筛选、质量评估和数据提取。使用RevMan5.3Meta进行了元分析。共筛选出与本综述最相关的 12 篇文章，其中 10 篇为中文，2 篇为英文：结果显示，慢性阻塞性肺病患者的虚弱发生率为 26%（OR 0.26，95% CI 0.17~0.34）：讨论：COPD 患者体弱的主要危险因素是年龄（OR 1.32，95% CI 1.30~1.34）、GOLD 肺功能分级（OR 3.18，95% CI 2.14~4.71）、mMRC 评分（OR 3.90，95% CI 1.53~9.92）、合并症（OR 2.17，95% CI 1.结论：该研究通过荟萃分析提供了全面的证据：该研究通过荟萃分析提供了全面的证据，并提出慢性阻塞性肺病患者体弱的发生率为 26%。研究发现了一些风险因素，包括年龄、根据 GOLD 标准划分的肺功能等级、mMRC 评分、合并多种药物营养不良、抑郁或一年内入院 2 次或以上。建议临床医务人员及早识别这些风险因素。
The Incidence and Risk Factors of Frailty in Patients with Chronic Obstructive Pulmonary Disease: A Meta-Analysis.
Objective: COPD patients have a high incidence of frailty and numerous complications, which seriously affect their quality of life. This study systematically evaluated and analyzed the current state of frailty incidence and risk factors in COPD patients to reduce the prevalence of frailty and enhance their quality of life.
Method: The Cochrane Library, PubMed, Embase, Web of Science, CBM, CNKI, VIP, and Wanfang databases were searched for relevant studies from the inception of each database until November 2022. A thorough literature screening, quality evaluation, and data extraction was conducted. Meta-analysis was performed using RevMan5.3Meta. Twelve articles were selected as most relevant to this review; 10 were in Chinese, and 2 were in English.
Results: The results showed that the incidence of asthenia in COPD patients was 26% (OR 0.26, 95% CI 0.17~0.34).
Discussion: The main risk factors for frailty in COPD patients were age (OR 1.32, 95% CI 1.30~1.34), GOLD pulmonary function class (OR 3.18, 95% CI 2.14~4.71), mMRC score (OR 3.90, 95% CI 1.53~9.92), comorbidity (OR 2.17, 95% CI 1.48~3.18), polypharmacy (OR 6.74, 95% CI 3.23~14.08), malnutrition (OR 3.32, 95% CI 1.77~6.24), depression (OR 1.37, 95% CI 1.07~1.76) and ≥2 admissions within 1 year (OR 4.84, 95% CI 2.45~9.57).
Conclusion: The study presented comprehensive evidence through meta-analysis and proposed that the prevalence of frailty in COPD patients is 26%. Risk factors were identified, including age, pulmonary function class according to GOLD criteria, mMRC score, comorbidity polypharmacy malnutrition, depression, or 2 or more hospital admissions within a year. It is recommended that clinical medical staff identify these risk factors at an early stage.
期刊介绍：
Launched in 1995, Alternative Therapies in Health and Medicine has a mission to promote the art and science of integrative medicine and a responsibility to improve public health. We strive to maintain the highest standards of ethical medical journalism independent of special interests that is timely, accurate, and a pleasure to read. We publish original, peer-reviewed scientific articles that provide health care providers with continuing education to promote health, prevent illness, and treat disease. Alternative Therapies in Health and Medicine was the first journal in this field to be indexed in the National Library of Medicine. In 2006, 2007, and 2008, ATHM had the highest impact factor ranking of any independently published peer-reviewed CAM journal in the United States—meaning that its research articles were cited more frequently than any other journal’s in the field.
Alternative Therapies in Health and Medicine does not endorse any particular system or method but promotes the evaluation and appropriate use of all effective therapeutic approaches. Each issue contains a variety of disciplined inquiry methods, from case reports to original scientific research to systematic reviews. The editors encourage the integration of evidence-based emerging therapies with conventional medical practices by licensed health care providers in a way that promotes a comprehensive approach to health care that is focused on wellness, prevention, and healing. Alternative Therapies in Health and Medicine hopes to inform all licensed health care practitioners about developments in fields other than their own and to foster an ongoing debate about the scientific, clinical, historical, legal, political, and cultural issues that affect all of health care.
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