Filgrastim 用于治疗猫科动物处方错误后硫唑嘌呤诱发的骨髓抑制毒性。

IF 1.5 4区 农林科学 Q2 VETERINARY SCIENCES Journal of the American Animal Hospital Association Pub Date : 2024-05-01 DOI:10.5326/JAAHA-MS-7409
Leigh Klar
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引用次数: 0

摘要

目前只有一份报告称,在猫咪因硫唑嘌呤中毒而出现严重中性粒细胞减少症时,成功使用了丝裂霉素(粒细胞集落刺激因子)。在此,我们报告了一个病例,该病例中,医生给猫咪开了甲巯咪唑处方,但错误地使用了硫唑嘌呤片剂,而处方标签上标明的甲巯咪唑给药方案在发现错误前已使用了三天。就诊时,猫咪的身体检查结果与之前服用硫唑嘌呤前的检查结果一致。全血细胞计数显示中性粒细胞减少和白细胞减少。该猫后来出现了厌食、脱水和呕吐症状。治疗包括抗恶心和促进食欲药物、菲格拉司汀和抗生素。在治疗过程中,通过皮下注射 Filgrastim,中性粒细胞数量在抑制后有所增加。该猫在对治疗方案做出反应后完全康复。根据这一例猫科动物对菲格拉司汀的反应,可以考虑将其用于治疗硫唑嘌呤引起的猫中性粒细胞减少症。
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Filgrastim Use in the Treatment of Azathioprine-Induced Myelosuppression Toxicity After Prescription Error in the Feline.

Only one report on the successful use of filgrastim (granulocyte colony-stimulating factor) in cats for severe neutropenia following azathioprine toxicity exists. Here, we report on a case in which a cat was prescribed methimazole but the medication was filled incorrectly with azathioprine tablets and the prescription label indicated a methimazole dosing regimen that was administered for three days before recognition of the error. On presentation, the cat's physical examinations were consistent with previous examinations before ingestion of azathioprine. A complete blood cell count revealed neutropenia and leukopenia. The cat later developed hyporexia, dehydration, and vomiting. Treatment included antinausea and appetite stimulant medications, filgrastim, and antibiotics. Filgrastim given as subcutaneous injections over the course of treatment increased neutrophil cell counts after suppression. The cat made a full recovery after responding to the treatment protocol. Based on the perceived response to filgrastim in this single feline case report, its use can be considered for the treatment of azathioprine-induced neutropenia in cats.

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来源期刊
CiteScore
2.70
自引率
0.00%
发文量
57
审稿时长
18-36 weeks
期刊介绍: The purpose of the JAAHA is to publish relevant, original, timely scientific and technical information pertaining to the practice of small animal medicine and surgery.
期刊最新文献
2022 AAHA Canine Vaccination Guidelines (2024 Update). 2024 AAHA Community Care Guidelines for Small Animal Practice. Long-term Outcome of a Chihuahua With Idiopathic Syndrome of Inappropriate Antidiuretic Hormone Secretion. Outcome, Complications, and Follow-Up in Dogs Treated with Pancarpal Arthrodesis Stabilized with Orthogonal Plates. Successful Management of Incompletely Resected Transitional Cell Carcinoma with Sorafenib Tosylate in a Dog.
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