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2022 AAHA Canine Vaccination Guidelines (2024 Update). 2022 年 AAHA 犬类疫苗接种指南(2024 年更新)。
IF 1.5 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-11-01 DOI: 10.5326/JAAHA-MS-7468
John Ellis, Elizabeth Marziani, Chumkee Aziz, Catherine M Brown, Leah A Cohn, Christopher Lea, George E Moore, Neha Taneja

Vaccination is a cornerstone of canine preventive healthcare and one of the most cost-effective ways of maintaining a dog's health, longevity, and quality of life. Canine vaccination also serves a public health function by forming a barrier against several zoonotic diseases affecting dogs and humans. Canine vaccines are broadly categorized as containing core and noncore immunizing antigens, with administration recommendations based on assessment of individual patient risk factors. The guidelines include a comprehensive table listing canine core and noncore vaccines and a recommended vaccination and revaccination schedule for each vaccine. The guidelines explain the relevance of different vaccine formulations, including those containing modified-live virus, inactivated, and recombinant immunizing agents. Factors that potentially affect vaccine efficacy are addressed, including the patient's prevaccination immune status and vaccine duration of immunity. Because animal shelters are one of the most challenging environments for prevention and control of infectious diseases, the guidelines also provide recommendations for vaccination of dogs presented at or housed in animal shelters, including the appropriate response to an infectious disease outbreak in the shelter setting. The guidelines explain how practitioners can interpret a patient's serological status, including maternally derived antibody titers, as indicators of immune status and suitability for vaccination. Other topics covered include factors associated with postvaccination adverse events, vaccine storage and handling to preserve product efficacy, interpreting product labeling to ensure proper vaccine use, and using client education and healthcare team training to raise awareness of the importance of vaccinations.

疫苗接种是犬类预防保健的基石,也是保持犬类健康、长寿和生活质量的最具成本效益的方法之一。犬类疫苗接种还具有公共卫生功能,可形成一道屏障,防止影响犬类和人类的几种人畜共患病。犬用疫苗大致分为含有核心和非核心免疫抗原的疫苗,其使用建议基于对患者个体风险因素的评估。该指南包括一个列出犬类核心和非核心疫苗的综合表格,以及每种疫苗的建议接种和再接种时间表。指南解释了不同疫苗制剂的相关性,包括含有改良活病毒、灭活和重组免疫制剂的疫苗。指南还讨论了可能影响疫苗效力的因素,包括患者接种前的免疫状态和疫苗免疫持续时间。由于动物收容所是预防和控制传染病最具挑战性的环境之一,因此指南还对动物收容所中出现或收容的犬只的疫苗接种提出了建议,包括在收容所环境中爆发传染病时的适当应对措施。指南解释了从业人员如何将患者的血清学状态(包括母源抗体滴度)解释为免疫状态和是否适合接种疫苗的指标。其他主题还包括与接种后不良事件相关的因素、疫苗储存和处理以保持产品功效、解释产品标签以确保疫苗的正确使用,以及利用客户教育和医疗团队培训来提高对疫苗接种重要性的认识。
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引用次数: 0
2024 AAHA Community Care Guidelines for Small Animal Practice. 2024 AAHA《小动物医院社区护理指南》。
IF 1.5 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-11-01 DOI: 10.5326/JAAHA-MS-7464
Mike Greenberg, Donita McCants, Elizabeth Alvarez, Elizabeth Berliner, Michael Blackwell, Emily McCobb, Tierra Price, Jyothi Robertson, Melina Stambolis

Community care is a creative way of thinking about health care that mobilizes resources within a community and consists of four core principles: recognition of the urgency of access-to-care for the veterinary profession, collaboration within community networks, family-centered health care, and redefining the gold standard of care. The AAHA Community Care Guidelines for Small Animal Practice offer strategies to help busy veterinary practitioners increase access to care within their practice and community by optimizing collaborative networks. While these guidelines do not claim to provide exhaustive solutions to access-to-care issues, they propose a starting point from which private practices can explore and implement workable solutions for their community and their practice. Broadening the scope of care to reach all people with pets requires multimodal, collaborative, and creative solutions both within and outside of the veterinary profession. These solutions can begin with greater communication and collaboration between private veterinary practices and nonprofit veterinary practices, with the goal of keeping pets in their homes with their loving families as much as reasonably possible.

社区护理是一种创造性的医疗保健思维方式,可调动社区内的资源,包括四项核心原则:认识到兽医行业获得护理服务的紧迫性、社区网络内的协作、以家庭为中心的医疗保健以及重新定义护理的黄金标准。美国兽医协会小动物诊所社区护理指南》提供了一些策略,帮助繁忙的兽医从业者通过优化合作网络,在诊所和社区内增加获得护理的机会。虽然这些指南并不声称能为获得护理问题提供详尽无遗的解决方案,但它们提出了一个起点,私人诊所可以从这个起点出发,为其社区和诊所探索并实施可行的解决方案。要扩大护理范围,使所有养宠物的人都能得到护理,就需要在兽医行业内外采取多模式、协作性和创造性的解决方案。这些解决方案可以从加强私人兽医诊所和非营利性兽医诊所之间的沟通与合作开始,目标是尽可能合理地将宠物留在家中,与爱它们的家人在一起。
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引用次数: 0
Long-term Outcome of a Chihuahua With Idiopathic Syndrome of Inappropriate Antidiuretic Hormone Secretion. 一只患有抗利尿激素分泌不当特发性综合征的吉娃娃的长期治疗结果
IF 1.5 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-11-01 DOI: 10.5326/JAAHA-MS-7453
Darcy B Adin, Ilana Levinzon, Autumn N Harris

An approximately 3 yr old female Chihuahua was presented for evaluation of polyuria and polydipsia noted by the owner after adoption. Serum biochemistry and urinalysis revealed hyponatremia, hypochloremia, hypo-osmolality, and normal fractional excretion of sodium. Serum antidiuretic hormone concentration was 5.54 pg/mL and serum copeptin concentration was 135.40 pg/mL. The antidiuretic hormone value was above the reported range for healthy dogs and was considered inappropriate in light of serum osmolality. Idiopathic syndrome of inappropriate antidiuretic hormone secretion was considered the most likely diagnosis after excluding other potential causes, such as diuretic use, renal disease, adrenal disease, and thyroid dysfunction. The dog remains clinically well 2 yr after diagnosis without specific treatment other than minimal dietary salt supplementation. This case is unique because of the absence of systemic or neurologic signs, good long-term outcome without treatment, and use of novel diagnostic testing.

一只约 3 岁大的雌性吉娃娃犬在被主人收养后出现多尿和多尿症状,前来接受评估。血清生化和尿液分析表明,该犬患低钠血症、低氯血症、低渗透压症,钠的部分排泄量正常。血清抗利尿激素浓度为 5.54 pg/mL,血清 copeptin 浓度为 135.40 pg/mL。抗利尿激素值高于健康犬的报告范围,根据血清渗透压,认为该值不合适。在排除使用利尿剂、肾脏疾病、肾上腺疾病和甲状腺功能障碍等其他潜在原因后,特发性抗利尿激素分泌不当综合征被认为是最有可能的诊断。确诊 2 年后,该犬临床状况良好,除饮食中补充少量食盐外,未接受其他特殊治疗。该病例之所以独特,是因为它没有全身或神经系统症状,无需治疗即可获得良好的长期疗效,而且使用了新型诊断测试。
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引用次数: 0
Successful Management of Incompletely Resected Transitional Cell Carcinoma with Sorafenib Tosylate in a Dog. 用索拉非尼-对甲苯磺酸盐成功治疗一只未完全切除的输尿管细胞癌。
IF 1.5 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-11-01 DOI: 10.5326/JAAHA-MS-7463
Dongheon Shin, Chaerin Kim, Yeon Chae, Taesik Yun, Byeong-Teck Kang, Kyung-Mee Park, Hakhyun Kim

Most urinary bladder (UB) tumors are malignant, and transitional cell carcinoma (TCC) is the most common neoplasm affecting the UB in dogs. Sorafenib may be a potential therapeutic agent for canine TCC. A 12 yr old spayed female Maltese dog weighing 3.6 kg and with a history of hematuria was referred for a suspected UB tumor. Abdominal ultrasonography revealed a UB mass attached to the cranioventral wall. The remaining abdominal examinations, including that of the lymph nodes, were unremarkable. Ultrasound-guided traumatic catheterization of the UB mass was performed, and the cytological evaluation of the UB mass indicated TCC. Excision was performed by partial cystectomy, and histopathology confirmed TCC, although the tumor had infiltrated the surgical margins. A chemosensitivity assay was conducted using tissue from the excised tumor. Sorafenib tosylate, a tyrosine kinase inhibitor, showed the greatest effect in the chemosensitivity assay. Therefore, adjuvant chemotherapy with sorafenib tosylate and piroxicam was administered postoperatively. The dog lived without any clinical signs, including hematuria or tumor relapse, for more than 2 yr after the surgery. This is the first report of successful long-term management of TCC with sorafenib tosylate in a dog.

大多数膀胱(UB)肿瘤都是恶性的,而过渡细胞癌(TCC)是影响犬膀胱的最常见肿瘤。索拉非尼可能是治疗犬 TCC 的潜在药物。一只 12 岁的绝育雌性马尔济斯犬体重 3.6 千克,曾有血尿病史,因怀疑患有 UB 肿瘤而转诊。腹部超声波检查发现颅腹壁上有一个UTB肿块。包括淋巴结在内的其他腹部检查均无异常。在超声引导下对膀胱肿块进行了创伤性导管插入术,膀胱肿块的细胞学评估显示为 TCC。通过膀胱部分切除术进行了切除,组织病理学证实为 TCC,尽管肿瘤已浸润到手术边缘。利用切除的肿瘤组织进行了化疗敏感性检测。在化疗敏感性试验中,酪氨酸激酶抑制剂索拉非尼(Sorafenib tosylate)的效果最佳。因此,术后对该犬进行了索拉非尼 tosylate 和吡罗昔康的辅助化疗。该犬在术后 2 年多的时间里没有出现任何临床症状,包括血尿或肿瘤复发。这是首例成功使用甲磺酸索拉非尼长期治疗犬 TCC 的报告。
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引用次数: 0
Treatment of Nonsocial Environmental Fear in a Service Dog Using Fluoxetine and Behavior Modification. 使用氟西汀和行为矫正治疗服务犬的非社交环境恐惧。
IF 1.5 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-11-01 DOI: 10.5326/JAAHA-MS-7455
Michael Zafar Khan, Sara Lynn Bennett

Training and maintaining a service dog requires extensive time and financial resources. The emotional bond between service dogs and their handlers poses unique challenges when dogs develop behavioral issues. We present a case of an otherwise healthy adult service dog exhibiting acute environmental fears, hindering her job performance. The dog's fear responses escalated in various settings, including school and home environments. Diagnostic evaluation ruled out medical pathology, leading to a diagnosis of nonsocial environmental fear and generalized anxiety. A multimodal treatment approach involving environmental management, antidepressant medication (fluoxetine), and behavior modification was implemented. Desensitization and counterconditioning protocols targeted specific triggers, such as shiny floors and elevators. Eight weeks after treatment initiation, the dog showed improvement, enabling a modified behavior treatment plan to be implemented as she gradually returned to work with reduced fear responses. Follow-up revealed sustained progress with additional dosage adjustment of fluoxetine.

训练和维护一只服务犬需要大量的时间和财力。当犬只出现行为问题时,服务犬与驯犬员之间的情感纽带会带来独特的挑战。我们介绍了一个案例,一只原本健康的成年役犬表现出了对环境的强烈恐惧,妨碍了它的工作表现。在包括学校和家庭环境在内的各种环境中,该犬的恐惧反应不断升级。诊断评估排除了医学病理的可能性,最终诊断为非社交环境恐惧和广泛性焦虑。医生采取了多模式治疗方法,包括环境管理、抗抑郁药物(氟西汀)和行为矫正。脱敏和反条件疗法针对的是特定的诱发因素,如发亮的地板和电梯。治疗开始八周后,该犬的情况有所改善,因此可以实施修改后的行为治疗计划,它逐渐恢复了工作,恐惧反应也有所减少。随访结果显示,在调整氟西汀的剂量后,该犬的病情持续好转。
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引用次数: 0
Urine Contamination Prevalence Using a Midstream Collection Device Compared with Clean Voided Collections in Dogs. 使用中游收集装置和清洁排尿收集装置收集犬尿液的污染率比较。
IF 1.5 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-11-01 DOI: 10.5326/JAAHA-MS-7415
Meghan Hoel, Faye A Hartmann, Michael R Lasarev, Michael W Wood

Collecting clean-caught voided urine samples is minimally invasive, but contamination occurs when urine passes through the nonsterile urethra and external genitalia. Discarding the initial urine stream may reduce these contaminants. This study hypothesized that using a midstream urine collection device would decrease bacterial and cellular contamination as compared with cleanly caught voided urine. This descriptive cross-sectional study collected urine from dogs using standard clean-caught (SCC), midstream collection device (MCD), and cystocentesis (CYS) techniques. Urinalysis and aerobic urine culture characteristics were recorded with each characteristic's prevalence described using percentages and 95% confidence intervals for each mode of collection. Positive urine culture prevalence did not differ between SCC and MCD (adjusted P value = .099); however, CYS had a lower prevalence compared with SCC and MCD (adjusted P values of <.001 [CYS versus SCC] and 0.009 [CYS versus MCD]). For other variables, there was no difference in prevalence when comparing SCC with MCD. There was no identified advantage to collecting urine using an MCD as compared with the SCC technique. Either option is a suitable alternative when CYS is not practical; however, clinicians need to interpret results cautiously because bacterial contamination is more common as compared with CYS.

收集干净的排空尿液样本创伤很小,但尿液通过未经消毒的尿道和外生殖器时会造成污染。丢弃最初的尿流可减少这些污染物。本研究假设,使用中段尿液收集装置会比干净收集的排空尿液减少细菌和细胞污染。这项描述性横断面研究采用标准清洁捕捉(SCC)、中游尿液收集装置(MCD)和膀胱穿刺(CYS)技术收集狗的尿液。研究人员记录了尿液分析和需氧尿培养的特征,并用百分比和 95% 的置信区间描述了每种收集方式下每种特征的流行率。尿培养阳性率在 SCC 和 MCD 之间没有差异(调整后的 P 值 = .099);但 CYS 的阳性率低于 SCC 和 MCD(调整后的 P 值 = .099)。
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引用次数: 0
Outcome, Complications, and Follow-Up in Dogs Treated with Pancarpal Arthrodesis Stabilized with Orthogonal Plates. 使用正交钢板稳定腕关节的狗的疗效、并发症和随访。
IF 1.5 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-11-01 DOI: 10.5326/JAAHA-MS-7421
Alba Rial García, Charlie Brincin, Andrew Craig

Pancarpal arthrodesis was performed in 21 dogs, using orthogonal (cranial/dorsal and medial) plates without postoperative rigid external coaptation. Short-term and long-term outcomes, arthrodesis progression, and complications were assessed using a retrospective review of case records and radiographs. Three of 21 (14.2%) dogs required a revision surgery: 2 had total implant explantation and 1 had a screw removed. Other complications were managed successfully medically. One of 21 (4.8%) dogs had confirmed deep surgical site infection requiring implant removal, and 4 of 21 (19%) had suspected (not confirmed on microbiology) superficial surgical site infections that resolved with medical management. Long-term outcomes were assessed via owner questionnaire (Canine Brief Pain Inventory) and were available for nine dogs at a mean of 26.78 mo after surgery. The mean score for the first part (assessment of pain) was 7.83/40, which is classified as no pain to mild pain. The mean score for the second part (assessment of function) was 12.67/60, which is classified as very good. The last part (overall impression) was defined as excellent in four dogs (44.44%), very good in one dog (11.11%), and good in the other four dogs (44.44%). This retrospective study documents a suitable technique for pancarpal arthrodesis in dogs with carpal injuries.

对21只狗进行了腕骨关节置换术,使用的是正交(颅骨/背骨和内侧)钢板,术后未使用硬质外固定。通过对病例记录和 X 光片进行回顾性审查,对短期和长期疗效、关节置换术进展和并发症进行了评估。21只狗中有3只(14.2%)需要进行翻修手术:2只需要将植入物全部取出,1只需要将螺钉取出。其他并发症都得到了成功的药物治疗。21 条狗中有 1 条(4.8%)证实手术部位深部感染,需要移除植入物,21 条狗中有 4 条(19%)怀疑手术部位表皮感染(微生物学未证实),通过药物治疗后感染得到缓解。通过犬主问卷(犬简易疼痛量表)评估长期疗效,9 只犬在术后平均 26.78 个月时进行了评估。第一部分(疼痛评估)的平均得分为 7.83/40,属于无痛至轻微疼痛。第二部分(功能评估)的平均得分为 12.67/60,属于非常好。最后一部分(总体印象)有四只狗(44.44%)被评为 "优秀",一只狗(11.11%)被评为 "非常好",另外四只狗(44.44%)被评为 "良好"。这项回顾性研究记录了一种适用于腕骨损伤犬的腕骨关节置换术技术。
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引用次数: 0
Resolution of Canine Acute Bilirubin Encephalopathy and Immune-Mediated Hemolytic Anemia Following Four Plasmapheresis Treatments. 犬急性胆红素脑病和免疫性溶血性贫血经四次血浆置换治疗后缓解。
IF 1.5 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-09-01 DOI: 10.5326/JAAHA-MS-7430
Nolan V Chalifoux, Brett Montague, Curtis Rheingold, Rachel Clarkin-Breslin, Erica L Reineke

An 8 mo old spayed female mixed-breed dog was presented for pale mucous membranes. The dog was diagnosed with intravascular immune-mediated hemolytic anemia (IMHA) and was started on medical management including corticosteroids, thromboprophylaxis, a packed red blood cell transfusion, and IV immunoglobulin. The dog developed severe hyperbilirubinemia (total bilirubin 48.1 mg/dL) and was referred for centrifugal plasmapheresis. Before treatment, the dog was stuporous to comatose, had intermittent opisthotonos, forelimb extension, and an absent menace consistent with acute bilirubin encephalopathy (ABE). The dog underwent a previously reported protocol of three therapeutic plasma exchange (TPE) treatments 24 hr apart. Moderate improvement was noted in her neurological status, although autoagglutination and hemolysis persisted, and the protocol was deemed inadequate. A fourth TPE treatment was performed on day 6. The following morning, the dog was autoagglutination negative. Her neurological status gradually improved, and she was discharged from the hospital on day 12. The dog remains neurologically normal and continues to do well at home on monotherapy with mycophenolate. Continued plasmapheresis treatments should be offered as a treatment option for severe cases of IMHA in the face of persistent disease, because TPE is able to provide ongoing support and stabilization, particularly in the face of ABE.

一只 8 个月大的绝育雌性混种犬因粘膜苍白前来就诊。该犬被诊断为血管内免疫介导的溶血性贫血(IMHA),并开始接受药物治疗,包括皮质类固醇、血栓预防、输注红细胞和静脉注射免疫球蛋白。该犬出现了严重的高胆红素血症(总胆红素 48.1 毫克/分升),被转到离心血浆置换术治疗。治疗前,该犬昏迷至昏迷,有间歇性肌张力不全、前肢伸展和威胁消失,与急性胆红素脑病(ABE)一致。该犬接受了之前报道过的治疗方案,即三次治疗性血浆置换(TPE),每次间隔 24 小时。虽然自体凝集和溶血现象持续存在,但该犬的神经状况得到了一定程度的改善,因此该方案被认为是不够的。第 6 天进行了第四次 TPE 治疗。第二天早上,该犬自身凝集素阴性。它的神经状况逐渐好转,并于第 12 天出院。该犬的神经系统仍然正常,在家中继续接受霉酚酸单药治疗,情况良好。对于面临顽固性疾病的严重 IMHA 病例,应将持续的浆细胞分离治疗作为一种治疗选择,因为 TPE 能够提供持续的支持和稳定,尤其是在 ABE 的情况下。
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引用次数: 0
Bacterial Prostatitis Secondary to Salmonella enterica serovar Enteritidis in an Immunocompetent Dog. 一只免疫功能正常的狗继发肠炎沙门氏菌肠道菌引起的细菌性前列腺炎
IF 1.5 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-09-01 DOI: 10.5326/JAAHA-MS-7428
Samantha Harvey, Elisa McEntee, Stephen Cole

Salmonella is a rod-shaped gram-negative bacterium of the family Enterobacteriaceae, commonly present in the gastrointestinal tract in humans and animals. Salmonella-associated bacteriuria and prostatitis are rare but have been reported in humans, predominantly older patients with underlying diseases, including urinary tract obstructions, diabetes mellitus, and compromised immunity. In dogs, Salmonella bacteriuria and prostatitis have only been described in patients on immunosuppressive medications. This study reports the case of a 7 yr old male Pit bull terrier mix with Salmonella prostatitis. The patient had a 3 day history of lethargy and anorexia. He was fed a commercial diet and had no previous medical or medication history. On physical examination, he had caudal abdominal pain and a firm, enlarged, painful prostate. Ultrasound revealed marked prostatomegaly with multifocal echogenic fluid-filled cavitations and regional peritonitis. Urine and prostatic fluid culture grew Salmonella (>100,000 colony-forming units/mL) using standard culture methods. Treatment with enrofloxacin was initiated for 8 wk. Repeat urine and prostatic cultures after cessation of antibiotics were negative, and serial fecal cultures were Salmonella negative. This case report is, to the best of our knowledge, the first to describe Salmonella prostatitis and bacteriuria in an immunocompetent dog who was not fed a raw diet.

沙门氏菌是肠杆菌科的一种杆状革兰氏阴性菌,常见于人类和动物的胃肠道。沙门氏菌相关性菌尿和前列腺炎在人类中很少见,但也有报道,主要是患有基础疾病(包括尿路梗阻、糖尿病和免疫力低下)的老年患者。在狗身上,沙门氏菌菌尿和前列腺炎只出现在服用免疫抑制药物的患者身上。本研究报告了一例患有沙门氏菌前列腺炎的 7 岁雄性比特斗牛梗混血犬。患者有 3 天的嗜睡和厌食史。它吃的是商品粮,以前没有病史或用药史。体格检查时,它尾部腹痛,前列腺坚硬、肿大、疼痛。超声波检查发现他的前列腺明显肿大,伴有多灶性回声性充液空洞和区域性腹膜炎。采用标准培养方法,尿液和前列腺液培养出沙门氏菌(>100,000 菌落总数单位/毫升)。开始使用恩诺沙星治疗 8 周。停用抗生素后,重复尿液和前列腺培养结果均为阴性,连续粪便培养结果也为沙门氏菌阴性。据我们所知,本病例报告是第一份描述免疫功能正常但未吃生食的狗患沙门氏菌前列腺炎和菌尿的病例报告。
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引用次数: 0
Relapse Risk Factors for Immune-Mediated Hemolytic Anemia: A Retrospective Study of 163 Dogs. 免疫性溶血性贫血的复发风险因素:对 163 条狗的回顾性研究。
IF 1.5 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-09-01 DOI: 10.5326/JAAHA-MS-7371
Sidney Bannister, Deborah Keys, Ewan Wolff

Immune-mediated hemolytic anemia (IMHA) is defined as an immune-mediated destruction of erythrocytes. Relapses are recognized, but risk factors are poorly defined. We hypothesized that a lower packed cell volume (PCV) on presentation, more transfusions during hospitalization, or a higher total bilirubin would be associated with an increased risk of relapse. IMHA was defined as a PCV less than 30% at diagnosis with two of the following identified: spherocytes, positive Coombs test, elevated total bilirubin, hemoglobinemia, or positive slide agglutination. This was a retrospective study evaluating 163 dogs between January 2005 and December 2019 from one specialty hospital. There were 13 relapses. The probability (95% confidence interval [CI]) of relapse by 3 and 12 mo was 0.05 (0.02-0.13) and 0.11 (0.06-0.22). The probability (95% CI) of relapse by 12 mo in patients who required two or more transfusions was 0.20 (0.09-0.42) compared with 0.07 (0.02-0.19) in patients who did not (P = .191). A lower PCV at diagnosis was not associated with an increased risk of relapse (hazard ratio [95% CI] 0.95 [0.86-1.04], P = .238). A higher total bilirubin was associated with a significantly increased risk of relapse (P = .003). With each increase of 1 mg/dL of total bilirubin, there was a 0.17 (95% CI 0.06-0.28) increase in the probability of relapse. These patients would likely need closer monitoring.

免疫介导的溶血性贫血(IMHA)被定义为免疫介导的红细胞破坏。人们已经认识到溶血性贫血会复发,但对其风险因素却知之甚少。我们假设,患者发病时包装细胞容积(PCV)较低、住院期间输血次数较多或总胆红素较高会增加复发风险。IMHA 的定义是:确诊时 PCV 低于 30%,同时发现以下两种情况:球形细胞、库姆斯氏试验阳性、总胆红素升高、血红蛋白血症或玻片凝集试验阳性。这是一项回顾性研究,对一家专科医院 2005 年 1 月至 2019 年 12 月间的 163 只犬进行了评估。共有 13 只犬复发。3个月和12个月后复发的概率(95%置信区间[CI])分别为0.05(0.02-0.13)和0.11(0.06-0.22)。需要输血两次或两次以上的患者 12 个月后复发的概率(95% 置信区间)为 0.20 (0.09-0.42),而不需要输血的患者复发的概率为 0.07 (0.02-0.19)(P = .191)。诊断时 PCV 较低与复发风险增加无关(危险比 [95% CI] 0.95 [0.86-1.04],P = .238)。总胆红素升高与复发风险显著增加有关(P = .003)。总胆红素每增加 1 毫克/分升,复发的可能性就增加 0.17 (95% CI 0.06-0.28)。这些患者可能需要更密切的监测。
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引用次数: 0
期刊
Journal of the American Animal Hospital Association
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