性别和糖尿病对心力衰竭患者的影响

IF 3.8 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-05-03 DOI:10.1007/s11897-024-00666-w
Sara Álvarez-Zaballos, Manuel Martínez-Sellés
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引用次数: 0

摘要

综述目的:心力衰竭(HF)是一种复杂的临床综合征,对全球健康造成日益沉重的负担。这篇综述探讨了心力衰竭、糖尿病和性别之间的相互关系,突出强调了流行病学模式、病理生理学机制和治疗意义:最近的研究结果:尽管男性和女性的高血压发病率相似,但糖尿病(DM)似乎对女性的高血压预后产生了更明显的影响。病理生理学差异涉及心血管风险因素、严重左心室功能障碍和冠状动脉疾病,以及激素影响和炎症标志物。糖尿病心肌病是一项具有性别特异性的挑战,女性常见的不良后果与纤维化加重和心肌重塑有关。治疗策略,尤其是钠-葡萄糖共转运体 2 抑制剂,对心血管有益,但对女性的反应可能有所不同。心房颤动与糖尿病之间的联系是双向的,糖尿病会显著增加心房颤动的风险,反之亦然。此外,糖尿病对死亡率的影响在女性中似乎比在男性中更明显,从而改变了在心房颤动结果中观察到的传统性别差距。个性化的治疗方法至关重要,需要进一步研究如何在心房颤动、糖尿病和性别的复杂相互作用中改善预后。
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Impact of Sex and Diabetes in Patients with Heart Failure.

Purpose of review: Heart failure (HF) is a complex clinical syndrome with a growing global health burden. This review explores the intersection of HF, diabetes mellitus, and sex, highlighting epidemiological patterns, pathophysiological mechanisms, and treatment implications.

Recent findings: Despite similar HF prevalence in men and women, diabetes mellitus (DM) appears to exert a more pronounced impact on HF outcomes in women. Pathophysiological differences involve cardiovascular risk factors, severe left ventricular dysfunction, and coronary artery disease, as well as hormonal influences and inflammatory markers. Diabetic cardiomyopathy introduces a sex-specific challenge, with women experiencing common adverse outcomes related to increased fibrosis and myocardial remodeling. Treatment strategies, particularly sodium-glucose cotransporter 2 inhibitors, exhibit cardiovascular benefits, but their response may differ in women. The link between HF and DM is bidirectional, with diabetes significantly increasing the risk of HF, and vice versa. Additionally, the impact of diabetes on mortality appears more pronounced in women than in men, leading to a modification of the traditional gender gap observed in HF outcomes. A personalized approach is crucial, and further research to improve outcomes in the complex interplay of HF, diabetes, and sex is needed.

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来源期刊
Current Heart Failure Reports
Current Heart Failure Reports Medicine-Emergency Medicine
CiteScore
5.30
自引率
0.00%
发文量
44
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of heart failure. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as investigative, pharmacologic, and nonpharmacologic therapies, pathophysiology, and prevention. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
期刊最新文献
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