Haowei Zhou, Yuchen Zhang, Tian Tian, Bingqian Wang, Yalei Pan
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引用次数: 0
摘要
本研究旨在探讨骨关节炎与微量元素锌和铜的关系，为骨关节炎的预防、诊断和治疗提供相关机制研究的理论依据。我们检索了截至2024年1月10日Web Of Science、Embase和PubMed收录的所有文献，总结了骨关节炎患者锌和铜的检测指标，通过文献筛选、质量评估和数据提取获得了临床数据，并使用Revman 5.4对数据进行了分析。本研究共收录了 13 篇论文，研究对象共计 7983 人。这些研究对象分为骨关节炎组和健康对照组。荟萃分析的结果表明，与健康人相比，骨关节炎患者的循环铜水平显著升高，但锌水平并不高。骨关节炎患者血液中的铜含量明显高于健康人。
Meta-analysis of the Relationship Between Zinc and Copper in Patients with Osteoarthritis.
This study aims to explore the relationship between osteoarthritis and the trace elements zinc and copper and to provide a theoretical basis for research on the related mechanisms for the prevention, diagnosis, and treatment of osteoarthritis. We searched all the literature indexed in Web Of Science, Embase, and PubMed as of January 10, 2024, summarized the zinc and copper detection indexes in patients with osteoarthritis, obtained clinical data through literature screening, quality assessment, and data extraction, and analyzed the data using Revman 5.4. A total of 13 papers were included in this study, totaling 7983 study subjects. These were divided into osteoarthritis and healthy control groups. The results from the meta-analysis showed that in patients with osteoarthritis, circulating copper levels, but not zinc levels, were significantly higher compared to healthy individuals. The level of copper in the blood of patients with osteoarthritis is significantly higher than that of healthy people.
期刊介绍：
Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.
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