昆虫衍生化合物的药物发现潜力:综述。

Nafiur Rahman, Arpita Gope, Jayeeta Khanrah, Anjali Rawani
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摘要

昆虫是地球上数量最多、种类最丰富的生物集合。在世界各地,人类社会一直利用昆虫和从昆虫身上提取的材料作为医疗资源。与其他物种一样,这些节肢动物也利用化学。根据生存需要,它们会做出适应性调整,包括保护自己免受感染和捕食,能够与社会生活建立联系,以及在环境中世代生存。化学生态学研究的重点是节肢动物体内用于这些生态适应的大量化合物。这一透彻的分析总结了从节肢动物中发现具有医疗功效的新天然化合物的巨大潜力。昆虫及其衍生物用途广泛,其 "原料产品 "在制药、组织工程、牙科、植物和农业科学、兽医、化妆品、药妆、食品和营养保健品等众多行业都取得了长足的进步。从昆虫中提取的生物活性成分正在成为潜在的治疗来源,对多种疾病有益。昆虫种类繁多,是低分子生物活性天然化合物的一个令人感兴趣的潜在来源,这些化合物或由昆虫本身产生,或由伴随的微生物产生。本综述整理了昆虫衍生化合物的最新情况、世界各地对昆虫的使用情况以及昆虫衍生物的药物发现潜力。
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Drug Discovery Potential of Insect-Derived Compounds: A review.

Insects are the most numerous and diverse collection of organisms on earth. Around the world, human societies have utilised insects and the materials derived from them as medical resources. These arthropods use chemistry, like all other species. According to their survival needs, they make adaptations, including protecting themselves from infection as well as predation, being able to connect with a social life, and carrying out generations with survivability in the environment. The main focus of the study of chemical ecology is the abundance of chemical compounds found in arthropods that are used for these ecological adaptations. This thorough analysis summarises the huge potential for finding new natural compounds with medical benefits from the Arthropods. Insects and their derivatives have a wide range of uses, and their "raw products" have made significant strides in a wide range of industries, including pharmaceuticals, tissue engineering, dentistry, plant and agricultural science, veterinary medicine, cosmetics, and cosmeceuticals, food, and nutraceuticals, among others. Bioactive components derived from insects are emerging as potential therapeutic sources that are beneficial against a variety of disorders. Insects, which have a huge variety of species, are an intriguing and potential source of low molecular biologically active natural compounds that are either produced by the insect itself or by accompanying microbes. The present review work collated the updates of insect-derived compounds, the use of insects worldwide, and drug discovery potential of insect derivatives.

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