新诊断乳腺癌患者的健康相关体能与患者报告症状之间的关系。

IF 9.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Journal of Sport and Health Science Pub Date : 2024-11-01 Epub Date: 2024-05-01 DOI:10.1016/j.jshs.2024.04.012
Ki-Yong An, Fernanda Z Arthuso, Myriam Filion, Spencer J Allen, Stephanie M Ntoukas, Gordon J Bell, Jessica McNeil, Qinggang Wang, Margaret L McNeely, Jeff K Vallance, Lin Yang, S Nicole Culos-Reed, Leanne Dickau, John R Mackey, Christine M Friedenreich, Kerry S Courneya
{"title":"新诊断乳腺癌患者的健康相关体能与患者报告症状之间的关系。","authors":"Ki-Yong An, Fernanda Z Arthuso, Myriam Filion, Spencer J Allen, Stephanie M Ntoukas, Gordon J Bell, Jessica McNeil, Qinggang Wang, Margaret L McNeely, Jeff K Vallance, Lin Yang, S Nicole Culos-Reed, Leanne Dickau, John R Mackey, Christine M Friedenreich, Kerry S Courneya","doi":"10.1016/j.jshs.2024.04.012","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life, treatment outcomes, and survival. Preventing and managing breast cancer-related symptoms soon after diagnosis is essential. The purpose of this study was to investigate the associations between health-related fitness (HRF) and patient-reported symptoms in newly diagnosed breast cancer patients.</p><p><strong>Methods: </strong>This study utilized baseline data from the Alberta Moving Beyond Breast Cancer Cohort Study that were collected within 90 days of diagnosis. HRF measures included peak cardiopulmonary fitness (peak volume of oxygen consumption (VO<sub>2peak</sub>)), maximal muscular strength and endurance, flexibility, and body composition. Symptom measures included depression, sleep quality, and fatigue. Adjusted multivariable logistic regression was performed for analyses.</p><p><strong>Results: </strong>Of 1458 participants, 51.5% reported poor sleep quality, 26.5% reported significant fatigue, and 10.4% reported moderate depression. In multivariable-adjusted models, lower relative VO<sub>2peak</sub> was independently associated with a greater likelihood of all symptom measures, including moderate depression (p < 0.001), poor sleep quality (p = 0.009), significant fatigue (p = 0.008), any symptom (p < 0.001), and multiple symptoms (p < 0.001). VO<sub>2peak</sub> demonstrated threshold associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest quartile. The strength of the threshold associations varied by the symptom measure with odds ratios ranging from ∼1.5 for poor sleep quality to ∼3.0 for moderate depression and multiple symptoms. Moreover, lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner (p = 0.001), and higher body weight was independently associated with poor sleep quality in an inverted U pattern (p = 0.021).</p><p><strong>Conclusion: </strong>Relative VO<sub>2peak</sub> appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diagnosed breast cancer patients. Other HRF parameters may also be important for specific symptoms. Exercise interventions targeting different HRF components may help newly diagnosed breast cancer patients manage specific symptoms and improve outcomes.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":null,"pages":null},"PeriodicalIF":9.7000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11336311/pdf/","citationCount":"0","resultStr":"{\"title\":\"Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients.\",\"authors\":\"Ki-Yong An, Fernanda Z Arthuso, Myriam Filion, Spencer J Allen, Stephanie M Ntoukas, Gordon J Bell, Jessica McNeil, Qinggang Wang, Margaret L McNeely, Jeff K Vallance, Lin Yang, S Nicole Culos-Reed, Leanne Dickau, John R Mackey, Christine M Friedenreich, Kerry S Courneya\",\"doi\":\"10.1016/j.jshs.2024.04.012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life, treatment outcomes, and survival. Preventing and managing breast cancer-related symptoms soon after diagnosis is essential. The purpose of this study was to investigate the associations between health-related fitness (HRF) and patient-reported symptoms in newly diagnosed breast cancer patients.</p><p><strong>Methods: </strong>This study utilized baseline data from the Alberta Moving Beyond Breast Cancer Cohort Study that were collected within 90 days of diagnosis. HRF measures included peak cardiopulmonary fitness (peak volume of oxygen consumption (VO<sub>2peak</sub>)), maximal muscular strength and endurance, flexibility, and body composition. Symptom measures included depression, sleep quality, and fatigue. Adjusted multivariable logistic regression was performed for analyses.</p><p><strong>Results: </strong>Of 1458 participants, 51.5% reported poor sleep quality, 26.5% reported significant fatigue, and 10.4% reported moderate depression. In multivariable-adjusted models, lower relative VO<sub>2peak</sub> was independently associated with a greater likelihood of all symptom measures, including moderate depression (p < 0.001), poor sleep quality (p = 0.009), significant fatigue (p = 0.008), any symptom (p < 0.001), and multiple symptoms (p < 0.001). VO<sub>2peak</sub> demonstrated threshold associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest quartile. The strength of the threshold associations varied by the symptom measure with odds ratios ranging from ∼1.5 for poor sleep quality to ∼3.0 for moderate depression and multiple symptoms. Moreover, lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner (p = 0.001), and higher body weight was independently associated with poor sleep quality in an inverted U pattern (p = 0.021).</p><p><strong>Conclusion: </strong>Relative VO<sub>2peak</sub> appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diagnosed breast cancer patients. Other HRF parameters may also be important for specific symptoms. Exercise interventions targeting different HRF components may help newly diagnosed breast cancer patients manage specific symptoms and improve outcomes.</p>\",\"PeriodicalId\":48897,\"journal\":{\"name\":\"Journal of Sport and Health Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":9.7000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11336311/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Sport and Health Science\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jshs.2024.04.012\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/5/1 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"HOSPITALITY, LEISURE, SPORT & TOURISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Sport and Health Science","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jshs.2024.04.012","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/1 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"HOSPITALITY, LEISURE, SPORT & TOURISM","Score":null,"Total":0}
引用次数: 0

摘要

背景:新确诊的乳腺癌患者会出现一些症状,这些症状可能会影响他们的生活质量、治疗效果和生存期。在确诊后尽快预防和控制乳腺癌相关症状至关重要。本研究旨在调查新诊断乳腺癌患者的健康相关体能(HRF)与患者报告症状之间的关联:本研究利用了阿尔伯塔省超越乳腺癌(AMBER)队列研究的基线数据,这些数据是在确诊后 90 天内收集的。HRF测量指标包括心肺功能峰值(VO2峰值)、最大肌肉力量和耐力、柔韧性和身体成分。症状测量包括抑郁、睡眠质量和疲劳。分析结果采用调整后的多变量逻辑回归法:在 1458 名参与者中,51.5% 报告睡眠质量差,26.5% 报告明显疲劳,10.4% 报告中度抑郁。在多变量调整模型中,相对 VO2 峰值越低,出现所有症状的可能性越大,包括中度抑郁(p < 0.001)、睡眠质量差(p = 0.009)、明显疲劳(p = 0.008)、任何症状(p < 0.001)和多种症状(p < 0.001)。VO2peak 与所有症状指标都有阈值关联,因此与最高四分位数相比,所有三个较低的四分位数都表现出类似的风险升高。阈值关联的强度因症状测量而异,几率比从睡眠质量差的∼1.5到中度抑郁和多种症状的∼3.0不等。此外,相对较低的上半身肌肉耐力也以剂量反应的方式与疲劳独立相关(p = 0.001),而较高的体重则以倒 U 型模式与睡眠质量差独立相关(p = 0.021):结论:在新诊断的乳腺癌患者中,相对 VO2 峰值似乎是与患者报告的多种症状相关的关键心率变异成分。其他心率变异参数可能对特定症状也很重要。针对不同心率变异成分的运动干预可帮助新诊断的乳腺癌患者控制特定症状并改善预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients.

Background: Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life, treatment outcomes, and survival. Preventing and managing breast cancer-related symptoms soon after diagnosis is essential. The purpose of this study was to investigate the associations between health-related fitness (HRF) and patient-reported symptoms in newly diagnosed breast cancer patients.

Methods: This study utilized baseline data from the Alberta Moving Beyond Breast Cancer Cohort Study that were collected within 90 days of diagnosis. HRF measures included peak cardiopulmonary fitness (peak volume of oxygen consumption (VO2peak)), maximal muscular strength and endurance, flexibility, and body composition. Symptom measures included depression, sleep quality, and fatigue. Adjusted multivariable logistic regression was performed for analyses.

Results: Of 1458 participants, 51.5% reported poor sleep quality, 26.5% reported significant fatigue, and 10.4% reported moderate depression. In multivariable-adjusted models, lower relative VO2peak was independently associated with a greater likelihood of all symptom measures, including moderate depression (p < 0.001), poor sleep quality (p = 0.009), significant fatigue (p = 0.008), any symptom (p < 0.001), and multiple symptoms (p < 0.001). VO2peak demonstrated threshold associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest quartile. The strength of the threshold associations varied by the symptom measure with odds ratios ranging from ∼1.5 for poor sleep quality to ∼3.0 for moderate depression and multiple symptoms. Moreover, lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner (p = 0.001), and higher body weight was independently associated with poor sleep quality in an inverted U pattern (p = 0.021).

Conclusion: Relative VO2peak appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diagnosed breast cancer patients. Other HRF parameters may also be important for specific symptoms. Exercise interventions targeting different HRF components may help newly diagnosed breast cancer patients manage specific symptoms and improve outcomes.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
18.30
自引率
1.70%
发文量
101
审稿时长
22 weeks
期刊介绍: The Journal of Sport and Health Science (JSHS) is an international, multidisciplinary journal that aims to advance the fields of sport, exercise, physical activity, and health sciences. Published by Elsevier B.V. on behalf of Shanghai University of Sport, JSHS is dedicated to promoting original and impactful research, as well as topical reviews, editorials, opinions, and commentary papers. With a focus on physical and mental health, injury and disease prevention, traditional Chinese exercise, and human performance, JSHS offers a platform for scholars and researchers to share their findings and contribute to the advancement of these fields. Our journal is peer-reviewed, ensuring that all published works meet the highest academic standards. Supported by a carefully selected international editorial board, JSHS upholds impeccable integrity and provides an efficient publication platform. We invite submissions from scholars and researchers worldwide, and we are committed to disseminating insightful and influential research in the field of sport and health science.
期刊最新文献
The wearable landscape: Issues pertaining to the validation of the measurement of 24-h physical activity, sedentary, and sleep behavior assessment. The Paris 2024 Olympic and Paralympic Games. Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients. Risk factors for running-related injuries: An umbrella systematic review. Reactive oxygen species promote endurance exercise-induced adaptations in skeletal muscles.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1