C3 显性塌陷性局灶节段性肾小球硬化症--两例罕见病例的报告。

IF 0.8 Q4 UROLOGY & NEPHROLOGY Indian Journal of Nephrology Pub Date : 2024-01-01 Epub Date: 2023-03-07 DOI:10.4103/ijn.ijn_250_22

Mythri Shankar, Sreedhara C Gurusiddiah, K S Vinay, Kishan Aralapuram, Ranjitha Siddalingappa, Gouri Satheesh

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引用次数: 0

摘要

塌陷性局灶节段性肾小球硬化症（FSGS）是一组异质性疾病，而非单一疾病实体。肾活检显示肾小球毛细血管节段性或整体性塌陷、硬化。上覆的肾小球上皮细胞也会肥大和增生。免疫荧光呈阴性或有免疫球蛋白和 C3 的非特异性沉积。我们介绍了两例 C3 显性塌陷性 FSGS。两例病例对治疗均无反应，预后不佳。这就需要研究补体途径在 FSGS 发病机制中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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C3 Dominant Collapsing Focal Segmental Glomerulosclerosis - A Report of Two Rare Cases.

Collapsing focal segmental glomerulosclerosis (FSGS) a heterogeneous group of disorders, rather than a single disease entity. Kidney biopsy shows segmental or globally collapsed, sclerotic glomerular capillaries. There is also hypertrophy and hyperplasia of overlying glomerular epithelial cells. Immuno-fluorescence is negative or has non-specific deposits of immunoglobulins and C3. We present two cases of C3 dominant collapsing FSGS. Both the cases were non-responsive to therapy and had a poor outcome. This calls for research to study the role of the complement pathway in the pathogenesis of FSGS.

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