癌症管理中 MR 光谱的最新进展:仪器、采集和分析方面的进展。

IF 5.6 Q1 ONCOLOGY Radiology. Imaging cancer Pub Date : 2024-05-01 DOI:10.1148/rycan.230101
Eva Martinez Luque, Zexuan Liu, Dongsuk Sung, Rachel M Goldberg, Rishab Agarwal, Aditya Bhattacharya, Nadine S Ahmed, Jason W Allen, Candace C Fleischer
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引用次数: 0

摘要

磁共振光谱(MRS)是一种非侵入性成像方法,能够以局部、多重和非电离的方式对组织进行化学和分子分析。由于代谢重编程是癌症的一个特征,MRS 为癌症诊断、预后、治疗监测和患者管理提供了宝贵的代谢和分子信息。本综述介绍了 MRS 用于临床癌症管理的最新情况。第一部分概述了 MRS 的原理、当前的方法和感兴趣的常规代谢物。综述的其余部分集中在三个关键领域:仪器的进步,特别是超高强度 MRI 扫描仪和混合系统;新兴的采集方法,包括氘成像、超极化碳 13 MRI 和 MRS、化学交换饱和转移、扩散加权 MRS、MR 指纹和快速采集;以及人工智能辅助分析。综述最后提出了未来的建议,以促进 MRS 在癌症管理中的常规应用。关键词MR 光谱 光谱成像 肿瘤学分子成像 代谢重编程 临床癌症管理 © RSNA, 2024.
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An Update on MR Spectroscopy in Cancer Management: Advances in Instrumentation, Acquisition, and Analysis.

MR spectroscopy (MRS) is a noninvasive imaging method enabling chemical and molecular profiling of tissues in a localized, multiplexed, and nonionizing manner. As metabolic reprogramming is a hallmark of cancer, MRS provides valuable metabolic and molecular information for cancer diagnosis, prognosis, treatment monitoring, and patient management. This review provides an update on the use of MRS for clinical cancer management. The first section includes an overview of the principles of MRS, current methods, and conventional metabolites of interest. The remainder of the review is focused on three key areas: advances in instrumentation, specifically ultrahigh-field-strength MRI scanners and hybrid systems; emerging methods for acquisition, including deuterium imaging, hyperpolarized carbon 13 MRI and MRS, chemical exchange saturation transfer, diffusion-weighted MRS, MR fingerprinting, and fast acquisition; and analysis aided by artificial intelligence. The review concludes with future recommendations to facilitate routine use of MRS in cancer management. Keywords: MR Spectroscopy, Spectroscopic Imaging, Molecular Imaging in Oncology, Metabolic Reprogramming, Clinical Cancer Management © RSNA, 2024.

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