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Erratum for: Integrating Contrast-enhanced US to O-RADS US for Classification of Adnexal Lesions with Solid Components: Time-intensity Curve Analysis versus Visual Assessment. 勘误表将对比增强 US 与 O-RADS US 相结合,对有实性成分的附件病变进行分类:时间强度曲线分析与目测评估。
IF 5.6 Q1 ONCOLOGY Pub Date : 2024-11-01 DOI: 10.1148/rycan.249024
Manli Wu, Ying Wang, Manting Su, Ruili Wang, Xiaofeng Sun, Rui Zhang, Liang Mu, Li Xiao, Hong Wen, Tingting Liu, Xiaotao Meng, Licong Huang, Xinling Zhang
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引用次数: 0
Safety and Feasibility of Interventional Hybrid Fluoroscopy and Nuclear Imaging in the Work-up Procedure of Hepatic Radioembolization. 介入性混合透视和核成像在肝脏放射性栓塞术工作程序中的安全性和可行性。
IF 5.6 Q1 ONCOLOGY Pub Date : 2024-11-01 DOI: 10.1148/rycan.240044
Martijn M A Dietze, Marjolein B M Meddens, Rob van Rooij, Arthur J A T Braat, Bart de Keizer, Rutger C G Bruijnen, Marnix G E H Lam, Maarten L J Smits, Hugo W A M de Jong

Purpose To evaluate the safety and feasibility of a novel hybrid nuclear and fluoroscopy C-arm scanner to be used during the work-up procedure of hepatic radioembolization. Materials and Methods In this prospective first-in-human clinical study, 12 participants (median age, 67 years [range: 37-78 years]; nine [75%] male, three [25%] female) with liver tumors undergoing work-up for yttrium 90 radioembolization were included (ClinicalTrials.gov NCT06013774). Work-up angiography and technetium 99m-macroaggregated albumin injection were performed in an angiography suite equipped with a hybrid C-arm that could simultaneously perform fluoroscopy and planar nuclear imaging. Technetium 99m-macroaggregated albumin was injected under real-time hybrid imaging, followed by in-room SPECT imaging. Safety and feasibility were studied by assessing adverse events, technical performance, additional x-ray radiation dose, and questionnaires completed by radiologists and technologists. Results No adverse events were attributed to the hybrid C-arm scanner. The additional x-ray radiation dose was low (median, 19 Gy · cm2; minimum: 12 Gy · cm2; maximum: 21 Gy · cm2 for participants who completed all imaging steps). The interventional personnel considered use of the hybrid C-arm scanner safe and feasible, although the additional time spent in the intervention room was considered long (median, 64 minutes; minimum: 55 minutes; maximum: 77 minutes for participants who completed all imaging steps). Conclusion Use of the hybrid C-arm scanner during the work-up procedure of hepatic radioembolization was found to be safe and feasible in this first-in-human clinical study. Keywords: Angiography, Fluoroscopy, Interventional-Vascular, Radionuclide Studies, Radiosurgery, Gamma Knife, Cyberknife, SPECT, Instrumentation, Physics, Technical Aspects, Technology Assessment Supplemental material is available for this article. Published under a CC BY 4.0 license. Clinical trial registration no. NCT06013774.

目的 评估在肝脏放射栓塞治疗过程中使用新型核与透视混合 C 臂扫描仪的安全性和可行性。材料和方法 在这项前瞻性的首次人体临床研究中,共纳入了 12 名接受钇 90 放射栓塞检查的肝脏肿瘤患者(中位年龄 67 岁 [范围:37-78 岁];男性 9 人 [75%],女性 3 人 [25%])(ClinicalTrials.gov NCT06013774)。工作检查血管造影和锝99m宏观白蛋白注射是在血管造影室进行的,该造影室配备了可同时进行透视和平面核成像的混合C型臂。在实时混合成像下注射锝 99m 巨聚白蛋白,然后进行室内 SPECT 成像。通过评估不良事件、技术性能、额外的 X 射线辐射剂量以及放射科医生和技术人员填写的调查问卷,对安全性和可行性进行了研究。结果 混合 C 臂扫描仪未发生任何不良事件。额外的 X 射线辐射剂量较低(中位数:19 Gy - cm2;最小值:12 Gy - cm2;最大值:12 Gy - cm2):平方厘米;最低:12 Gy - cm2;最高:21 Gy - cm221 Gy - cm2)。介入人员认为使用混合 C 臂扫描仪安全可行,但介入室的额外时间较长(中位数:64 分钟;最少:55 分钟;最多:1 分钟):55分钟;最长完成所有成像步骤的参与者需要 77 分钟)。结论 在这项首次进行的人体临床研究中发现,在肝脏放射性栓塞术的检查过程中使用混合 C 臂扫描仪是安全可行的。关键词血管造影 透视 介入血管 放射性核素研究 放射外科 伽玛刀 赛博刀 SPECT 仪器 物理 技术方面 技术评估 本文有补充材料。以 CC BY 4.0 许可发布。临床试验注册号:NCT06013774。NCT06013774。
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引用次数: 0
Evaluating the Impact of Adjunctive Partial Cryoablation on Dual Checkpoint Inhibitor Immunotherapy Response in a Murine Model. 在小鼠模型中评估辅助性部分冷冻消融对双重检查点抑制剂免疫疗法反应的影响
IF 5.6 Q1 ONCOLOGY Pub Date : 2024-11-01 DOI: 10.1148/rycan.230187
Eric Wehrenberg-Klee, Perry Hampilos, Emily E Austin, Bahar Ataeinia, Abigail MacPherson, Thomas LaSalle, Umar Mahmood

Purpose To evaluate the impact of adjunctive partial cryoablation on checkpoint inhibitor (CPI) immunotherapy response. Materials and Methods One hundred fifty-six mice (equal number of male and female animals) with dual-implanted tumor models were treated with dual CPI or a vehicle and randomized to treatment of a single tumor with partial cryoablation. Tumors were followed for 60 days following cryoablation for response assessment. In additional groups, the tumor microenvironment was characterized via flow cytometry, cytokine analysis, and immunohistochemistry. Statistical comparison was made between the different treatment groups regarding T-cell infiltration and activation characteristics within the noncryoablated tumor and cytokine levels within the partially ablated tumor. Additionally, qualitative assessment of T-cell activation within the cryoablated and noncryoablated tumors at immunofluorescence was carried out. Results At 60 days following treatment, CPI and adjunctive cryoablation-treated MC-38 mice had a significantly increased survival rate (79%) compared with mice treated with CPI alone (61%; P < .001). CT-26 mice also had an increased survival rate (57% vs 35%, respectively; P = .04). Following cryoablation, increases in inflammatory cytokines and chemokines within the treated tumors were observed. Flow cytometry of noncryoablated tumor showed increased CD8 T-cell activation. Immunofluorescence and histologic evaluation following cryoablation further demonstrated a robust CD8 T-cell and myeloid infiltrate. Conclusion Adjunctive cryoablation significantly increased the response to dual CPI in multiple cancer models at both partially ablated and distant (nonablated) tumor sites. Immune analysis suggests cryoablation promotes a vigorous immune response within the partially cryoablated tumor that increases activation of the adaptive immune system within distant tumor sites. Keywords: Cancer, Cryoablation, Checkpoint Inhibitor Immunotherapy, Tumor Response Supplemental material is available for this article. © RSNA, 2024.

目的 评估辅助性部分冷冻消融对检查点抑制剂(CPI)免疫疗法反应的影响。材料与方法 对 156 只双植入肿瘤模型小鼠(雌雄数量相等)进行双 CPI 或载体治疗,并随机对单个肿瘤进行部分冷冻消融治疗。冷冻消融后对肿瘤进行 60 天的随访,以评估反应。在其他组中,通过流式细胞术、细胞因子分析和免疫组化鉴定肿瘤微环境。对不同治疗组的非冷冻消融肿瘤内的 T 细胞浸润和活化特征以及部分消融肿瘤内的细胞因子水平进行了统计比较。此外,还通过免疫荧光对冷冻消融和非冷冻消融肿瘤内的 T 细胞活化情况进行了定性评估。结果 在治疗后 60 天,CPI 和辅助冷冻消融治疗 MC-38 小鼠的存活率(79%)显著高于仅用 CPI 治疗的小鼠(61%;P < .001)。CT-26 小鼠的存活率也有所提高(分别为 57% 对 35%;P = .04)。冷冻消融后,观察到治疗肿瘤内的炎性细胞因子和趋化因子增加。非冷冻消融肿瘤的流式细胞术显示 CD8 T 细胞活化增加。冷冻消融后的免疫荧光和组织学评估进一步显示了强大的 CD8 T 细胞和髓细胞浸润。结论 在多种癌症模型中,无论是部分消融还是远处(未消融)肿瘤部位,辅助低温消融都能显著提高对双 CPI 的反应。免疫分析表明,低温消融可促进部分低温消融肿瘤内的强烈免疫反应,从而增强远处肿瘤部位适应性免疫系统的活化。关键词癌症 低温消融 检查点抑制剂免疫疗法 肿瘤反应 本文有补充材料。© RSNA, 2024.
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引用次数: 0
Addressing Discrepant Clinical Practice Patterns in Preoperative Breast MRI Use. 解决乳腺 MRI 术前使用的临床实践模式不一致问题。
IF 5.6 Q1 ONCOLOGY Pub Date : 2024-11-01 DOI: 10.1148/rycan.240380
Nhat-Tuan Tran, Randy C Miles
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引用次数: 0
Quantitative MRI in Childhood Neuroblastoma: Beyond the Assessment of Image-defined Risk Factors. 儿童神经母细胞瘤的定量 MRI:超越图像定义的风险因素评估。
IF 5.6 Q1 ONCOLOGY Pub Date : 2024-11-01 DOI: 10.1148/rycan.240089
Haoru Wang, Jinhua Cai

Neuroblastoma commonly occurs in children. MRI is a radiation-free imaging modality and has played an important role in identifying image-defined risk factors of neuroblastoma, providing necessary guidance for surgical resection and treatment response evaluation. However, image-defined risk factors are limited to providing structural information about neuroblastoma. With the evolution of MRI technologies, quantitative MRI can not only help assess image-defined risk factors but can also quantitatively reflect the biologic features of neuroblastoma in a noninvasive manner. Therefore, compared with anatomic imaging, these emerging quantitative MRI technologies are expected to provide more imaging biomarkers for the management of neuroblastoma. This review article discusses the current applications of quantitative MRI technologies in evaluating childhood neuroblastoma. Keywords: Pediatrics, MR-Functional Imaging, Children, MRI, Neuroblastoma, Quantitative Imaging © RSNA, 2024.

神经母细胞瘤常见于儿童。磁共振成像是一种无辐射成像模式,在确定神经母细胞瘤的图像定义风险因素方面发挥了重要作用,为手术切除和治疗反应评估提供了必要的指导。然而,图像定义的危险因素仅限于提供神经母细胞瘤的结构信息。随着核磁共振成像技术的发展,定量核磁共振成像不仅可以帮助评估图像定义的危险因素,还能以无创方式定量反映神经母细胞瘤的生物特征。因此,与解剖成像相比,这些新兴的定量 MRI 技术有望为神经母细胞瘤的治疗提供更多的成像生物标志物。这篇综述文章讨论了目前定量磁共振成像技术在评估儿童神经母细胞瘤中的应用。关键词儿科 MR-功能成像 儿童 MRI 神经母细胞瘤 定量成像 © RSNA, 2024.
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引用次数: 0
Exploring New Frontiers in Cryoablation and Immunotherapy Synergy. 探索低温消融与免疫疗法协同作用的新领域。
IF 5.6 Q1 ONCOLOGY Pub Date : 2024-11-01 DOI: 10.1148/rycan.240384
Delmarie M Rivera Rodríguez, Samdeep K Mouli
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引用次数: 0
Integrating Contrast-enhanced US to O-RADS US for Classification of Adnexal Lesions with Solid Components: Time-intensity Curve Analysis versus Visual Assessment. 将对比增强 US 与 O-RADS US 相结合,对有实性成分的附件病变进行分类:时间强度曲线分析与目测评估。
IF 5.6 Q1 ONCOLOGY Pub Date : 2024-11-01 DOI: 10.1148/rycan.240024
Manli Wu, Ying Wang, Manting Su, Ruili Wang, Xiaofeng Sun, Rui Zhang, Liang Mu, Li Xiao, Hong Wen, Tingting Liu, Xiaotao Meng, Licong Huang, Xinling Zhang

Purpose To compare the diagnostic performance of time-intensity curve (TIC) analysis and subjective visual assessment of contrast-enhanced US (CEUS) when integrated with the Ovarian-Adnexal Reporting and Data System (O-RADS) US risk stratification system for characterizing adnexal lesions with solid components. Materials and Methods In this prospective multicenter study conducted from September 2021 to December 2022, female individuals with suspected adnexal lesions containing solid components detected at routine US were enrolled. All participants underwent preoperative CEUS examinations. Histopathologic findings were used as the reference standard for diagnosis. Lesions were classified according to the O-RADS US system. Enhancement of solid tissue compared with the outer myometrium was evaluated using both TIC analysis and subjective visual assessment. The diagnostic performance of O-RADS alone and each CEUS assessment method when integrated with the O-RADS US system was assessed and compared using receiver operating characteristic curve analysis. Results A total of 180 lesions (80 malignant and 100 benign histopathologic outcomes) in 175 participants (median age, 47 years [IQR, 33-56]) were analyzed. Incorporating CEUS (assessed through both TIC analysis and subjective visual assessment) with O-RADS US showed significantly improved diagnostic performance over O-RADS US alone, with an area under the receiver operating characteristic curve (AUC) of 0.86 (95% CI: 0.80, 0.91) compared with 0.78 (95% CI: 0.71, 0.84). No evidence of a difference was observed between the AUCs of TIC analysis and subjective visual assessment in the enhancement evaluation of solid tissue with CEUS for adnexal malignancy categorization (P = .83). Conclusion Subjective visual assessment and TIC analysis of CEUS features when integrated with the O-RADS US scoring system showed comparable diagnostic performance in assigning adnexal malignancy risk. Keywords: Adnexal Lesions, Contrast-enhanced US, O-RADS, Time-intensity Curve Analysis Supplemental material is available for this article. © RSNA, 2024.

目的 比较对比增强造影剂 US(CEUS)的时间强度曲线(TIC)分析和主观视觉评估与卵巢-附件报告和数据系统(O-RADS)US 风险分层系统整合后对含有实性成分的附件病变的诊断性能。材料与方法 在这项于 2021 年 9 月至 2022 年 12 月进行的前瞻性多中心研究中,纳入了常规 US 检测到疑似附件病变(含实性成分)的女性患者。所有参与者均接受了术前 CEUS 检查。组织病理学检查结果作为诊断的参考标准。根据 O-RADS US 系统对病变进行分类。与子宫外层肌层相比,实性组织的增强情况通过 TIC 分析和主观视觉评估进行评估。使用接收器操作特征曲线分析法评估和比较了单独使用 O-RADS 和将每种 CEUS 评估方法与 O-RADS US 系统整合后的诊断性能。结果 对 175 名参与者(中位年龄 47 岁 [IQR,33-56])的 180 个病变(80 个恶性和 100 个良性组织病理学结果)进行了分析。将 CEUS(通过 TIC 分析和主观目测评估)与 O-RADS US 结合使用,诊断效果明显优于单独使用 O-RADS US,接收器操作特征曲线下面积 (AUC) 为 0.86(95% CI:0.80, 0.91),而 O-RADS US 为 0.78(95% CI:0.71, 0.84)。在使用 CEUS 对实体组织进行增强评估以进行附件恶性肿瘤分类时,未观察到 TIC 分析和主观视觉评估的 AUC 之间存在差异(P = 0.83)。结论 CEUS特征的主观视觉评估和TIC分析与O-RADS US评分系统相结合,在评估附件恶性肿瘤风险方面显示出相当的诊断性能。关键词附件病变 对比增强 US O-RADS 时间强度曲线分析 本文有补充材料。© RSNA, 2024.
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引用次数: 0
Racial Disparities in Preoperative Breast MRI Use and Surgical Margin Outcomes among Patients with Recently Diagnosed Breast Cancer. 新近确诊乳腺癌患者术前使用乳腺 MRI 和手术切缘结果的种族差异。
IF 5.6 Q1 ONCOLOGY Pub Date : 2024-11-01 DOI: 10.1148/rycan.240010
Amber Simmons, Lynn K Han, Jeffrey S Reiner, Victoria L Mango, Varadan Sevilimedu, Katja Pinker, Hong Zhang, Tracy-Ann Moo, Sarah Eskreis-Winkler

Purpose To evaluate racial disparities in preoperative breast MRI use and surgical margin outcomes among patients with recently diagnosed breast cancer. Materials and Methods This retrospective study included patients with breast cancer who presented to a single cancer center between 2008 and 2020, underwent breast surgery, and self-identified as White or Black. Patients were divided into MRI or no-MRI cohorts based on preoperative MRI use. MRI use and positive surgical margin rates were determined for all patients and racial subgroups. Data were collected from the electronic medical record and analyzed using the χ2 test for significance. Results The study included 28 384 female patients (mean age, 56 years ± 13 [SD]) with recently diagnosed breast cancer who self-identified as White (90.36%, n = 25 647) or Black (9.64%, n = 2737). Of the entire cohort, 32.78% (9305 of 28 384) underwent preoperative MRI. Black patients had a lower rate of preoperative MRI use than White patients (29.85% [817 of 2737] vs 33.10% [8488 of 25 647], respectively; P < .001). The MRI cohort had a lower positive margin rate compared with the no-MRI cohort (2.90% [133 of 4592] vs 4.78% [539 of 11 271], respectively; P = .03). In the no-MRI cohort, Black patients had a higher positive margin rate than White patients (6.17% [68 of 1103] vs 4.63% [471 of 10 168], respectively; P = .03). In the MRI cohort, there was no evidence of a difference in positive margin rates between Black and White patients (3.17% [12 of 379] vs 2.87% [121 of 4213], respectively; P = .90). Conclusion Compared with White patients, Black patients with breast cancer were less likely to undergo preoperative MRI and had a higher positive surgical margin rate. Keywords: MR Imaging, Breast Cancer, Breast MRI © RSNA, 2024 See also the commentary by Tran and Miles in this issue.

目的 评估近期确诊的乳腺癌患者术前使用乳腺核磁共振成像和手术切缘结果的种族差异。材料和方法 这项回顾性研究纳入了 2008 年至 2020 年期间在一家癌症中心就诊、接受乳腺手术并自称为白人或黑人的乳腺癌患者。根据术前磁共振成像的使用情况,将患者分为磁共振成像组群和无磁共振成像组群。确定所有患者和种族亚组的核磁共振成像使用率和手术切缘阳性率。数据收集自电子病历,并使用χ2检验进行显著性分析。结果 研究纳入了 28 384 名近期诊断为乳腺癌的女性患者(平均年龄为 56 岁 ± 13 [SD]),她们自我认同为白人(90.36%,n = 25 647)或黑人(9.64%,n = 2737)。在所有患者中,32.78%(28 384 人中的 9305 人)接受了术前磁共振成像检查。黑人患者的术前 MRI 使用率低于白人患者(分别为 29.85% [2737 例中的 817 例] vs 33.10% [25 647 例中的 8488 例];P < .001)。磁共振成像组患者的边缘阳性率低于无磁共振成像组患者(分别为 2.90% [4592 例中的 133 例] vs 4.78% [11 271 例中的 539 例];P = .03)。在无磁共振成像队列中,黑人患者的边缘阳性率高于白人患者(分别为 6.17% [1103 例中的 68 例] vs 4.63% [10 168 例中的 471 例];P = .03)。在核磁共振成像队列中,没有证据表明黑人和白人患者的边缘阳性率存在差异(分别为 3.17% [379 例中的 12 例] vs 2.87% [4213 例中的 121 例];P = .90)。结论 与白人患者相比,黑人乳腺癌患者接受术前磁共振成像的可能性较小,手术切缘阳性率较高。关键词MR 成像、乳腺癌、乳腺 MRI © RSNA, 2024 另请参阅本期 Tran 和 Miles 的评论。
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引用次数: 0
Accuracy and Impact of AI Software for Nodule and Cancer Detection at Lung Cancer Screening CT. 人工智能软件对肺癌 CT 筛查结节和癌症检测的准确性和影响。
IF 5.6 Q1 ONCOLOGY Pub Date : 2024-11-01 DOI: 10.1148/rycan.249025
Netanja I Harlianto, Pim A de Jong
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引用次数: 0
Interrater Reliability Assessment of the Brain Tumor Reporting and Data System (BT-RADS). 脑肿瘤报告和数据系统(BT-RADS)的内部可靠性评估。
IF 5.6 Q1 ONCOLOGY Pub Date : 2024-09-01 DOI: 10.1148/rycan.249016
Netanja I Harlianto
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引用次数: 0
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Radiology. Imaging cancer
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