[儿科抗苗勒氏管激素 (AMH):用富士比奥® Lumipulse G AMH 检测法确定参考值,并在相同儿科样本上与罗氏® Elecsys 检测法进行比较]。

Jean-Baptiste Delaye, Olivier Le Tilly, Emmanuel Enard, Christine Collet, Patrick Emond, Diane Dufour-Rainfray
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引用次数: 0

摘要

我们使用相同的儿科样本对Fujirebio® Lumipulse G AMH测定和Roche® Elecsys AMH测定进行了方法比较。我们描述了在Lumipulse G 600 II上使用Fujirebio® AMH测定法检测AMH的全部儿科性别和年龄特异性参考范围。这项研究是在用肝素锂试管采集的 281 份血浆样本中进行的。样本来自图尔大学医院中心采集的 3 天至 22 岁的患者(男性 135 人,女性 146 人)。Fujirebio® Lumipulse 方法与 Roche® Elecsys 方法的相关性极佳,但存在明显的正比例偏差。我们利用这些数据提出了适用于富士比奥®方法的儿科参考值。我们的研究描述了在Lumipulse G600II上使用Fujirebio® AMH检测法检测AMH的全部儿科性别和年龄相关参考范围。正常男性和女性AMH浓度之间的界限使其成为有价值的临床工具,用于监测小儿从幼儿期到青春期过渡到成年期的性发育和生殖发育情况。
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[Hormone anti-müllérienne (AMH) en pédiatrie : établissement de valeurs de référence avec le dosage de l'AMH Fujirebio® Lumipulse G et comparaison avec le dosage Roche® Elecsys sur les mêmes échantillons pédiatriques].

We performed a method comparison between the Fujirebio® Lumipulse G AMH assay and the Roche® Elecsys AMH assay using the same pediatric samples. We described full pediatric gender and age-specific reference ranges for AMH using the Fujirebio® AMH assay on the Lumipulse G 600 II. The study was performed on 281 plasma samples collected in tubes with lithium heparin. The samples were from patients (135 males and 146 females) aged from 3 days to 22 years collected at the University Hospital Center of Tours. The Fujirebio® Lumipulse method showed excellent correlation with Roche® Elecsys but had a significant proportional positive bias. The data were used to propose pediatric reference values adapted to the Fujirebio® method. Our study described full pediatric gender and age-related reference ranges for AMH using the Fujirebio® AMH assay on the Lumipulse G600II. The delineation between normal male and female AMH concentrations make them valuable clinical tools for the monitoring of pediatric sexual and reproductive development from early childhood through the pubertal transition into adulthood.

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