从分子亚型的角度看子宫内膜癌分类和管理策略的新视角。

IF 0.5 Q4 OBSTETRICS & GYNECOLOGY Ceska Gynekologie-Czech Gynaecology Pub Date : 2024-01-01 DOI:10.48095/cccg2024128
Zuzana Ballová, Petra Gašparová, Martina Sitáš, Erik Dosedla
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引用次数: 0

摘要

子宫内膜癌是最常见的妇科癌症,也是发达国家第二大女性恶性肿瘤。子宫内膜癌通常在绝经后妇女中确诊,以子宫异常出血为特征性临床症状。过去,人们只考虑两种组织学类型。然而,越来越明显的是,子宫内膜癌在临床上是一种异质性疾病,这种异质性与潜在的分子改变的多样性密切相关。癌症基因组图谱》(Cancer Genome Atlas)将子宫内膜癌分为四个分子亚组,每个亚组都有不同的突变负荷和拷贝数改变,从而大大推进了子宫内膜癌的诊断、风险分层和管理。
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A new perspective on Endometrial Carcinoma classification and management strategies in context of molecular subtypes.

Endometrial cancer is the most common gynecological cancer and the second most prevalent female malignancy in the developed world. It is typically diagnosed in postmenopausal women, presenting with the characteristic clinical symptom of uterine abnormal bleeding. In the past, only two histological types were considered. However, it has become increasingly evident that endometrial cancer is a clinically heterogeneous disease, and this heterogeneity is closely associated with the diversity of underlying molecular alterations. The Cancer Genome Atlas classification has significantly advanced the diagnosis, risk stratification, and management of endometrial cancer by categorizing it into four molecular subgroups, each characterized by distinct mutational burdens and copy number alterations.

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来源期刊
Ceska Gynekologie-Czech Gynaecology
Ceska Gynekologie-Czech Gynaecology OBSTETRICS & GYNECOLOGY-
CiteScore
0.60
自引率
25.00%
发文量
57
期刊最新文献
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