肌醇和维生素 D 在改善多囊卵巢综合征患者生育能力方面作用的系统性综述。

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY Clinical and Experimental Reproductive Medicine-CERM Pub Date : 2024-09-01 Epub Date: 2024-04-11 DOI:10.5653/cerm.2023.06485
Gitika Katyal, Gursharan Kaur, Hafsa Ashraf, Adiprasad Bodapati, Ayesha Hanif, Donatus Kaine Okafor, Safeera Khan
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引用次数: 0

摘要

多囊卵巢综合征(PCOS)是育龄妇女常见的内分泌和代谢紊乱疾病。多囊卵巢综合征是导致无排卵性不孕的主要原因之一,它使包括体外受精在内的生育治疗变得复杂。广泛接受的 2003 年鹿特丹多囊卵巢综合症诊断标准包括基于雄激素过多、排卵功能障碍和多囊卵巢形态变化的亚型。在本系统综述中,我们研究了肌醇和维生素 D 对多囊卵巢综合症患者生育力的影响。根据《2020 年系统综述和荟萃分析首选报告项目》指南,我们使用相关关键词对包括 PubMed、谷歌学术和 MDPI 在内的数据库进行了全面检索。在最初的 345 篇文章中,有 10 篇符合纳入标准。这些文章表明,维生素 D 和肌醇,尤其是肌醇和 D-chiro 肌醇,可能是多囊卵巢综合症的治疗选择。维生素 D 可影响卵巢卵泡的发育、血糖调节和胰岛素敏感性。与二甲双胍疗法结合使用时,可改善月经规律和排卵。肌醇对细胞信号传导、能量代谢、葡萄糖调节和生育能力至关重要。鉴于多囊卵巢综合症的发病率以及对生育和代谢健康的影响,本系统综述强调了在多囊卵巢综合症管理策略中研究肌醇和维生素 D 的重要性。尽管这些制剂显示出良好的前景,但更多的研究可以阐明它们的作用机制和治疗效果。本综述强调有必要探索有效的治疗方法,以改善多囊卵巢综合症患者的生活质量。肌醇和维生素 D 是潜在的选择,但还需要更多的研究来阐明它们在治疗这种疾病中的作用。
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Systematic Review of the roles of Inositol and Vitamin D in improving fertility among patients with Polycystic Ovary Syndrome.

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder among reproductive-age women. As a leading cause of anovulatory infertility, it complicates fertility treatments, including in vitro fertilization. The widely accepted 2003 Rotterdam diagnostic criteria for PCOS include sub-phenotypes based on variations in androgen excess, ovulatory dysfunction, and polycystic ovarian morphology. In this systematic review, we examined the impacts of inositol and vitamin D on fertility in PCOS. Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, we used relevant keywords to comprehensively search databases including PubMed, Google Scholar, and MDPI. From an initial pool of 345 articles, 10 met the inclusion criteria. The articles suggest that vitamin D and inositol, particularly myo-inositol and D-chiro-inositol, may represent therapeutic options for PCOS. Vitamin D influences ovarian follicular development, glucose regulation, and insulin sensitivity. When combined with metformin therapy, it is associated with improved menstrual regularity and ovulation. Inositol is crucial for cellular signaling, energy metabolism, glucose regulation, and fertility. This systematic review underscores the importance of investigating inositol and vitamin D within a PCOS management strategy, given the disorder's prevalence and impacts on fertility and metabolic health. Although these agents show promise, additional research could clarify their mechanisms of action and therapeutic benefits. This review emphasizes the need for exploration of effective treatments to improve the quality of life among individuals with PCOS. Inositol and vitamin D represent potential options, but more studies are required to elucidate their roles in the management of this condition.

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