多囊卵巢综合征疾病的数学研究,包括妇女不孕症的药物治疗机制。

IF 3.1 Q2 HEALTH CARE SCIENCES & SERVICES AIMS Public Health Pub Date : 2023-12-04 eCollection Date: 2024-01-01 DOI:10.3934/publichealth.2024002
Maryam Batool, Muhammad Farman, Aqeel Ahmad, Kottakkaran Sooppy Nisar
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引用次数: 0

摘要

在育龄妇女中,多囊卵巢综合征(PCOS)是最常见的内分泌疾病之一。除了降低女性生育能力外,这种疾病还会增加罹患心血管疾病、糖尿病、血脂异常、肥胖、精神障碍和其他疾病的风险。本文利用分数算子的记忆效应这一新颖方法,构建了多囊卵巢综合征的分数阶模型。为此,研究人群被分为四组:有不孕风险的妇女、多囊卵巢综合症患者、接受治疗(促性腺激素和枸橼酸氯米芬)的不孕妇女以及改善型不孕妇女。我们推导出了基本生殖数,利用雅各布矩阵和 Routh-Hurwitz 稳定性准则,可以证明自由平衡点和地方性平衡点都是局部稳定的。利用两步拉格朗日多项式,以幂律核的广义形式生成了解,以便通过数值模拟来探讨分式算子的影响,从而显示出不同参数的影响对妇女疾病的影响。
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Mathematical study of polycystic ovarian syndrome disease including medication treatment mechanism for infertility in women.

Among women of reproductive age, PCOS (polycystic ovarian syndrome) is one of the most prevalent endocrine illnesses. In addition to decreasing female fertility, this condition raises the risk of cardiovascular disease, diabetes, dyslipidemia, obesity, psychiatric disorders and other illnesses. In this paper, we constructed a fractional order model for polycystic ovarian syndrome by using a novel approach with the memory effect of a fractional operator. The study population was divided into four groups for this reason: Women who are at risk for infertility, PCOS sufferers, infertile women receiving therapy (gonadotropin and clomiphene citrate), and improved infertile women. We derived the basic reproductive number, and by utilizing the Jacobian matrix and the Routh-Hurwitz stability criterion, it can be shown that the free and endemic equilibrium points are both locally stable. Using a two-step Lagrange polynomial, solutions were generated in the generalized form of the power law kernel in order to explore the influence of the fractional operator with numerical simulations, which shows the impact of the sickness on women due to the effect of different parameters involved.

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来源期刊
AIMS Public Health
AIMS Public Health HEALTH CARE SCIENCES & SERVICES-
CiteScore
4.80
自引率
0.00%
发文量
31
审稿时长
4 weeks
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