酒精相关肝炎中的炎症:发病机制和治疗目标。

IF 7.1 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Cellular and Molecular Gastroenterology and Hepatology Pub Date : 2024-01-01 DOI:10.1016/j.jcmgh.2024.04.009
Dechun Feng , Seonghwan Hwang , Adrien Guillot , Yang Wang , Yukun Guan , Cheng Chen , Luca Maccioni , Bin Gao
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引用次数: 0

摘要

酒精相关性肝炎(AH)是慢性酒精相关性肝病(ALD)患者的一种急性慢性肝损伤。严重酒精相关性肝炎患者的短期死亡率很高,而且缺乏有效的药物疗法。炎症被认为是促进酒精相关性肝损伤进展的关键因素之一,在过去的几十年中,人们一直在积极地将炎症作为治疗靶点进行研究,但迄今为止尚未发现有效的炎症靶点。在这篇综述中,我们将以中性粒细胞和巨噬细胞为重点,讨论炎症细胞及其产生的炎症介质如何导致 AH 的发生和发展。我们还阐述了炎症细胞和肝脏非实质性细胞在 AH 发病机制中的相互影响。我们还讨论了近期尖端技术在描述 AH 中肝脏炎症特征方面的应用。最后,我们简要总结了炎症介质对 AH 的潜在治疗靶点。
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Inflammation in Alcohol-Associated Hepatitis: Pathogenesis and Therapeutic Targets

Alcohol-associated hepatitis (AH) is an acute-on-chronic liver injury that occurs in patients with chronic alcohol-associated liver disease (ALD). Patients with severe AH have high short-term mortality and lack effective pharmacologic therapies. Inflammation is believed to be one of the key factors promoting AH progression and has been actively investigated as therapeutic targets over the last several decades, but no effective inflammatory targets have been identified so far. In this review, we discuss how inflammatory cells and the inflammatory mediators produced by these cells contribute to the development and progression of AH, with focus on neutrophils and macrophages. The crosstalk between inflammatory cells and liver nonparenchymal cells in the pathogenesis of AH is elaborated. We also deliberate the application of recent cutting-edge technologies in characterizing liver inflammation in AH. Finally, the potential therapeutic targets of inflammatory mediators for AH are briefly summarized.

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来源期刊
CiteScore
13.00
自引率
2.80%
发文量
246
审稿时长
42 days
期刊介绍: "Cell and Molecular Gastroenterology and Hepatology (CMGH)" is a journal dedicated to advancing the understanding of digestive biology through impactful research that spans the spectrum of normal gastrointestinal, hepatic, and pancreatic functions, as well as their pathologies. The journal's mission is to publish high-quality, hypothesis-driven studies that offer mechanistic novelty and are methodologically robust, covering a wide range of themes in gastroenterology, hepatology, and pancreatology. CMGH reports on the latest scientific advances in cell biology, immunology, physiology, microbiology, genetics, and neurobiology related to gastrointestinal, hepatobiliary, and pancreatic health and disease. The research published in CMGH is designed to address significant questions in the field, utilizing a variety of experimental approaches, including in vitro models, patient-derived tissues or cells, and animal models. This multifaceted approach enables the journal to contribute to both fundamental discoveries and their translation into clinical applications, ultimately aiming to improve patient care and treatment outcomes in digestive health.
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