小儿慢性肾脏病的纵向血浆代谢组模式及其与肾功能和蛋白尿的关系

IF 8.5 1区 医学 Q1 UROLOGY & NEPHROLOGY Clinical Journal of the American Society of Nephrology Pub Date : 2024-07-01 Epub Date: 2024-05-06 DOI:10.2215/CJN.0000000000000463
Arthur M Lee, Yunwen Xu, Jian Hu, Rui Xiao, Stephen R Hooper, Erum A Hartung, Josef Coresh, Eugene P Rhee, Ramachandran S Vasan, Paul L Kimmel, Bradley A Warady, Susan L Furth, Michelle R Denburg
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引用次数: 0

摘要

导言:了解与小儿慢性肾脏病(CKD)肾功能变化相关的血浆代谢组模式对于继续研究确定新的生物标志物、描述生化病理生理学和开发有针对性的干预措施非常重要。有关纵向代谢组学的研究数量有限,而有关小儿慢性肾脏病的研究几乎为零:儿童慢性肾脏病(CKiD)研究是一项多机构前瞻性队列研究,研究对象为年龄在 6 个月到 16 岁之间、估计肾小球滤过率(eGFR)为 30-90 毫升/分钟/1.73 平方米的儿童。对基线、两年和四年研究访问的血浆样本进行了非靶向代谢组学分析。在基线检测和随访检测之间,所使用的代谢组学分析平台进行了技术更新。为了确定代谢物与所有三个时间点的 eGFR 或尿蛋白:肌酐(UPCR)的关系,我们采用了线性混合效应(LME)模型。为了确定代谢物与时间的关系,我们对两年和四年的随访数据应用了线性混合效应模型。我们采用线性回归分析来检验代谢物水平随时间的变化(Δlevel)与 eGFR(ΔeGFR)和 UPCR(ΔUPCR)变化之间的关联。我们根据错误发现率 (FDR) 结果报告显著性:共纳入 1156 人次(N:基线=626,2 年=254,4 年=276)。有 622 种代谢物在所有三个时间点都进行了标准化测量。在 LME 模型中,分别有 406 和 343 个代谢物与 FDRC 的 eGFR 和 UPCR 相关:我们描述了一个大型儿科慢性肾脏病人群中与 eGFR 和 UPCR 相关的纵向血浆代谢组学模式。在之前的 CKD 生物标志物联盟研究中,这些代谢物信号中有很多都与 CKD 进展、病因和蛋白尿有关。此外,还发现了一些新的代谢物与 eGFR 和蛋白尿有关。
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Longitudinal Plasma Metabolome Patterns and Relation to Kidney Function and Proteinuria in Pediatric CKD.
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来源期刊
CiteScore
12.20
自引率
3.10%
发文量
514
审稿时长
3-6 weeks
期刊介绍: The Clinical Journal of the American Society of Nephrology strives to establish itself as the foremost authority in communicating and influencing advances in clinical nephrology by (1) swiftly and effectively disseminating pivotal developments in clinical and translational research in nephrology, encompassing innovations in research methods and care delivery; (2) providing context for these advances in relation to future research directions and patient care; and (3) becoming a key voice on issues with potential implications for the clinical practice of nephrology, particularly within the United States. Original manuscript topics cover a range of areas, including Acid/Base and Electrolyte Disorders, Acute Kidney Injury and ICU Nephrology, Chronic Kidney Disease, Clinical Nephrology, Cystic Kidney Disease, Diabetes and the Kidney, Genetics, Geriatric and Palliative Nephrology, Glomerular and Tubulointerstitial Diseases, Hypertension, Maintenance Dialysis, Mineral Metabolism, Nephrolithiasis, and Transplantation.
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