糖尿病相关并发症的治疗干预。

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Current diabetes reviews Pub Date : 2024-05-03 DOI:10.2174/0115733998291870240408043837
Dharmendra Pradhan, Prafulla Kumar Sahu, Sukumar Purohit, Santosh Kumar Ranajit, Biswajeet Acharya, Shreya Sangam, Amit Kumar Shrivastava
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引用次数: 0

摘要

背景:糖尿病(DM)是一个令人担忧的健康问题,影响着全球约 5.37 亿人。作为发病和死亡的主要原因,糖尿病需要全面了解其不同的病理生理机制和疾病进展:本传统综述整合了有关高血糖发病机制、并发症进展以及最佳治疗策略进展的文献。方法:这篇传统综述整合了有关高血糖发病机制及其发展为并发症以及最佳治疗策略进展的文献。我们使用多个关键词,包括 "糖尿病"、"糖尿病相关并发症"、"糖尿病相关疾病的新型治疗干预措施"、"作为抗糖尿病药物的植物提取物 "等,在 PubMed、Scopus、Google Scholar、Web of Science 和 ClinicalTrials.gov 等著名数据库中对过去二十年的文献进行了综述:我们讨论了大血管和微血管并发症,如动脉粥样硬化、心血管疾病、外周动脉疾病 (PAD)、中风、糖尿病肾病、视网膜病变和神经病变,以及目前可用于治疗糖尿病的各种药物和非药物干预措施。我们还重点研究了天然产品在靶向碳水化合物代谢、胰岛素分泌、胰腺细胞修复和减少氧化应激等分子机制方面的潜力,从而促进了天然产品的抗糖尿病活性。此外,我们还探索了新的治疗方法,如基因、干细胞和免疫调节疗法。我们还讨论了每种干预措施的益处和局限性、新兴研究和技术以及精准医疗干预措施:本综述强调了进一步了解这些进展的必要性,这对于提高临床医生确定最有效治疗干预措施的能力至关重要。
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Therapeutic Interventions for Diabetes Mellitus-Associated Complications.

Background: Diabetes Mellitus (DM) is an alarming health concern, affecting approximately 537 million people worldwide. As a leading cause of morbidity and mortality, DM demands a comprehensive understanding of its diverse pathophysiological mechanisms and disease progression.

Methods: This traditional review has consolidated literature on the pathogenesis of hyperglycemia, its progression into complications, and advances in optimal treatment strategies. The literature in the last two decades has been reviewed using several keywords, including "diabetes," "diabetes-associated complications", "novel therapeutic interventions for diabetes-associated diseases", "phyto-extracts as antidiabetic drugs", etc. in prominent databases, such as PubMed, Scopus, Google Scholar, Web of Science, and ClinicalTrials.gov.

Results: We have discussed macrovascular and microvascular complications, such as atherosclerosis, cardiovascular disease, Peripheral Arterial Disease (PAD), stroke, diabetic nephropathy, retinopathy, and neuropathy, as well as various pharmacological and non-pharmacological interventions that are currently available for the management of DM. We have also focused on the potential of natural products in targeting molecular mechanisms involved in carbohydrate metabolism, insulin production, repair of pancreatic cells, and reduction of oxidative stress, thereby contributing to their antidiabetic activity. Additionally, novel therapeutic approaches, like genetic, stem cell, and immunomodulatory therapies, have been explored. We have also discussed the benefits and limitations of each intervention, emerging research and technologies, and precision medicine interventions.

Conclusion: This review has emphasized the need for an improved understanding of these advancements, which is essential to enhance clinicians' ability to identify the most effective therapeutic interventions.

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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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