Deekshitha Alla, Dhruv Jayeshkumar Shah, Muneesh Seepana, Rishabh Baskara Salian, Sai Santhosha Mrudula Alla, Midhun Krishna Mohanan, Mert Sabıroğlu, Mohan Sai Sunith Vegesna, Aradhya Singh, Srajan Gupta, Shushrutha Shivalingappa Rekha
{"title":"质子泵抑制剂在儿科人群中的安全性：系统回顾","authors":"Deekshitha Alla, Dhruv Jayeshkumar Shah, Muneesh Seepana, Rishabh Baskara Salian, Sai Santhosha Mrudula Alla, Midhun Krishna Mohanan, Mert Sabıroğlu, Mohan Sai Sunith Vegesna, Aradhya Singh, Srajan Gupta, Shushrutha Shivalingappa Rekha","doi":"10.1177/2333794X241248967","DOIUrl":null,"url":null,"abstract":"<p><p><i>Objective.</i> Commonly recommended drugs for adults and children include proton pump inhibitors (PPIs), proven effective for treating peptic diseases like stomach ulcers, GERD, and Helicobacter pylori infections in children over 1-year-old. Yet, prolonged PPI use carries higher risks of adverse reactions, prompting this study's analysis. <i>Methods.</i> We have performed a systematic review of 30 articles, which include a total of 762 505 pediatric patients. <i>Results.</i> Adverse effects were encountered in 6.98% of the population. The 5 most common adverse effects were respiratory tract complications, gastrointestinal complications, urinary tract infections, asthma, and ENT infections. <i>Conclusion.</i> Hence, PPIs should be prescribed only when necessary, and physicians should prioritize patient education when considering their use.</p>","PeriodicalId":12576,"journal":{"name":"Global Pediatric Health","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057350/pdf/","citationCount":"0","resultStr":"{\"title\":\"Safety of Proton Pump Inhibitors in Pediatric Population: A Systematic Review.\",\"authors\":\"Deekshitha Alla, Dhruv Jayeshkumar Shah, Muneesh Seepana, Rishabh Baskara Salian, Sai Santhosha Mrudula Alla, Midhun Krishna Mohanan, Mert Sabıroğlu, Mohan Sai Sunith Vegesna, Aradhya Singh, Srajan Gupta, Shushrutha Shivalingappa Rekha\",\"doi\":\"10.1177/2333794X241248967\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Objective.</i> Commonly recommended drugs for adults and children include proton pump inhibitors (PPIs), proven effective for treating peptic diseases like stomach ulcers, GERD, and Helicobacter pylori infections in children over 1-year-old. Yet, prolonged PPI use carries higher risks of adverse reactions, prompting this study's analysis. <i>Methods.</i> We have performed a systematic review of 30 articles, which include a total of 762 505 pediatric patients. <i>Results.</i> Adverse effects were encountered in 6.98% of the population. The 5 most common adverse effects were respiratory tract complications, gastrointestinal complications, urinary tract infections, asthma, and ENT infections. <i>Conclusion.</i> Hence, PPIs should be prescribed only when necessary, and physicians should prioritize patient education when considering their use.</p>\",\"PeriodicalId\":12576,\"journal\":{\"name\":\"Global Pediatric Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-04-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057350/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Global Pediatric Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/2333794X241248967\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Global Pediatric Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/2333794X241248967","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"PEDIATRICS","Score":null,"Total":0}
Safety of Proton Pump Inhibitors in Pediatric Population: A Systematic Review.
Objective. Commonly recommended drugs for adults and children include proton pump inhibitors (PPIs), proven effective for treating peptic diseases like stomach ulcers, GERD, and Helicobacter pylori infections in children over 1-year-old. Yet, prolonged PPI use carries higher risks of adverse reactions, prompting this study's analysis. Methods. We have performed a systematic review of 30 articles, which include a total of 762 505 pediatric patients. Results. Adverse effects were encountered in 6.98% of the population. The 5 most common adverse effects were respiratory tract complications, gastrointestinal complications, urinary tract infections, asthma, and ENT infections. Conclusion. Hence, PPIs should be prescribed only when necessary, and physicians should prioritize patient education when considering their use.
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