肝细胞与软杀疟原虫的艺术

IF 7 1区 医学 Q1 PARASITOLOGY Trends in parasitology Pub Date : 2024-06-01 Epub Date: 2024-05-06 DOI:10.1016/j.pt.2024.04.004
Camila Marques-da-Silva, Clyde Schmidt-Silva, Samarchith P Kurup
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引用次数: 0

摘要

导致疟疾的疟原虫在感染红细胞并引起临床疾病之前,会在肝脏实质细胞(肝细胞)中进行无症状发育。传统上,肝细胞被认为是被动的旁观者,允许疟原虫等致肝病原体在相对不受挑战的情况下发育。然而,现在有新的证据表明,肝细胞可以产生针对疟原虫的强大的细胞自主免疫反应,限制疟原虫在血液中的发展,降低临床疟疾的发病率和严重程度。在此,我们将讨论我们目前对针对疟原虫的肝细胞内在免疫反应以及这些途径如何影响疟疾的理解。
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Hepatocytes and the art of killing Plasmodium softly.

The Plasmodium parasites that cause malaria undergo asymptomatic development in the parenchymal cells of the liver, the hepatocytes, prior to infecting erythrocytes and causing clinical disease. Traditionally, hepatocytes have been perceived as passive bystanders that allow hepatotropic pathogens such as Plasmodium to develop relatively unchallenged. However, now there is emerging evidence suggesting that hepatocytes can mount robust cell-autonomous immune responses that target Plasmodium, limiting its progression to the blood and reducing the incidence and severity of clinical malaria. Here we discuss our current understanding of hepatocyte cell-intrinsic immune responses that target Plasmodium and how these pathways impact malaria.

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来源期刊
Trends in parasitology
Trends in parasitology 医学-寄生虫学
CiteScore
14.00
自引率
3.10%
发文量
148
审稿时长
6-12 weeks
期刊介绍: Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts. Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.
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