洋二仙草酚类化合物的抗炎活性

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL Phytochemistry Letters Pub Date : 2024-05-09 DOI:10.1016/j.phytol.2024.05.001

Dan Xu, Yajun Chen, Xu-Xu Cao, Jingjie Zheng, Yao Wang, Yan-Yan Ma, Kun Zhang, Deng-Gao Zhao

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引用次数: 0

摘要

一种新的二元丙烷（1）和十七种已知化合物（2-18）是从香叶石竹（Dianella ensifolia）的整个植株中提取出来的。经鉴定，化合物 1-3 是一类独特的二元丙烷。通过全面的光谱分析确定了它们的结构。抗炎活性测定显示，化合物 7 对脂多糖（LPS）刺激的 RAW 264.7 细胞中 NO 的生成有显著的抑制作用，IC50 值为 9.93 μg/mL。进一步的深入机理研究表明，化合物 7 通过抑制 NF-κB 的活化来抑制 LPS 诱导的一氧化氮生成，从而导致一氧化氮合酶（iNOS）的表达减少。

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Anti-inflammatory activity of phenolics from Dianella ensifolia

A new diarylpropane (1) along with seventeen known compounds (2–18), were extracted from the entire plant of Dianella ensifolia. The compounds 1–3 were identified as a distinctive group of diarylpropanes. Their structures were determined through comprehensive spectral analysis. An anti-inflammatory activity assay revealed that compound 7 demonstrated significant inhibitory effects on NO generation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, with an IC₅₀ value of 9.93 μg/mL. Further in-depth mechanistic studies indicated that compound 7 suppresses LPS-induced NO production by inhibiting the activation of NF-κB, which subsequently led to a decrease in the expression of nitric oxide synthase enzymes (iNOS).

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.