苯甲酸酯类衍生物对家蝇的毒性会导致严重的肌肉松弛和身体变形。

IF 1.4 3区 农林科学 Q2 ENTOMOLOGY Neotropical Entomology Pub Date : 2024-08-01 Epub Date: 2024-05-09 DOI:10.1007/s13744-024-01154-5
Asmaa A Kamel, Shawky M Aboelhadid, Abdel-Azeem S Abdel-Baki, Samar M Ibrahium, Saleh Al-Quraishy, Ahmed O Hassan, Shams G Abd El-Kareem, Sahar M Gadelhaq
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引用次数: 0

摘要

家蝇(Musca domestica (Linnaeus))(双翅目:鹟科)对人类和动物健康构成严重威胁,而且对多种杀虫剂具有抗药性。已知植物源苯甲酸盐对多种昆虫具有杀虫活性。本研究评估了苯甲酸酯衍生物(苯甲醇 BA、苯甲酸苄酯 BB 和苯甲酸甲酯 MB)的杀幼虫、杀蛹和杀成虫活性,并研究了它们对幼虫结构和乙酰胆碱酯酶活性的影响。通过残膜法和局部施用法,分别对幼虫和蛹施用了六种浓度(2.5 至 100 毫克/毫升)的苯甲酸酯衍生物。同时,通过熏蒸试验对成蝇施用了 0.625 至 50 毫克/升空气浓度的苯甲酸酯衍生物。BA 和 MB 对幼虫的半数致死浓度分别为 10.90 毫克/毫升和 11.53 毫克/毫升,取得了良好的效果。此外,当浓度为 25 毫克/毫升时,BA 能杀死 100%的幼虫,而当浓度为 50 毫克/毫升时,MB 也能达到同样的效果。关于杀蛹活性,浓度为 100 毫克/毫升时,MB 的抑制率(PIR)为 100%,而浓度为 50 毫克/毫升时,BA 也达到了同样的效果。同时,在任何测试浓度下,BB 对幼虫或蛹都没有任何影响。此外,通过扫描显微镜观察 BA 和 MB 处理过的幼虫,发现幼虫身体松弛畸形,角质层萎缩。此外,BA 和 MB 还能通过抑制乙酰胆碱酯酶来抑制神经信号的传递。总之,这项研究的结果表明,BA 和 MB 可用于控制家蝇种群。这些物质会导致昆虫肌肉严重松弛和畸形。
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Benzoate Derivatives Toxicity to Musca domestica Results in Severe Muscle Relaxation and Body Distortion.

The house fly, Musca domestica (Linnaeus) (Diptera: Muscidae), is a significant threat to human and animal health and is also resistant to a variety of insecticides. Plant-derived benzoates are known to have insecticidal activities against various insects. In this study, the larvicidal, pupicidal, and adulticidal activities of benzoate derivatives (benzyl alcohol BA, benzyl benzoate BB, and methyl benzoate MB) were assessed and investigated for their effects on larval structure and acetylcholinesterase activity. Six concentrations (2.5 to 100 mg/mL) of benzoate derivatives were applied to larvae and pupae through the residual film method and topical application, respectively. Meanwhile, concentrations from 0.625 to 50 mg/L air were applied to adult flies through a fumigation assay. BA and MB achieved promising results against larvae with LC50 values of 10.90 and 11.53 mg/mL, respectively. Moreover, BA killed 100% of the larvae at a concentration of 25 mg/mL, and MB achieved the same effect at a concentration of 50 mg/mL. Regarding the pupicidal activity, MB showed a percentage inhibition rate (PIR) of 100% at a concentration of 100 mg/mL, while the same effect was achieved by BA at a concentration of 50 mg/mL. Meanwhile, BB did not show any effect on the larvae or pupae at any of the tested concentrations. Moreover, the scanning microscopy observations on the treated larvae by BA and MB estimated flaccid and deformity in the larva body with a shrunken cuticle. Additionally, both BA and MB suppress nerve signal transmission by inhibiting acetylcholinesterase. In conclusion, the results of this study indicate that BA and MB may be useful in control housefly populations. These substances cause severe muscular relaxation and deformities in insects.

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来源期刊
Neotropical Entomology
Neotropical Entomology 生物-昆虫学
CiteScore
3.30
自引率
5.60%
发文量
69
审稿时长
6-12 weeks
期刊介绍: Neotropical Entomology is a bimonthly journal, edited by the Sociedade Entomológica do Brasil (Entomological Society of Brazil) that publishes original articles produced by Brazilian and international experts in several subspecialties of entomology. These include bionomics, systematics, morphology, physiology, behavior, ecology, biological control, crop protection and acarology.
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