嗅觉障碍患者嗅觉相关脑区结构协方差的变化

IF 1.8 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Experimental Neurobiology Pub Date : 2024-04-30 DOI:10.5607/en24007
Suji Lee, Yumi Song, Haejin Hong, Yoonji Joo, Eunji Ha, Youngeun Shim, Seung-No Hong, Jungyoon Kim, In Kyoon Lyoo, Sujung Yoon, Dae Woo Kim
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引用次数: 0

摘要

以嗅觉丧失为特征的嗅觉缺失症不仅与外周嗅觉系统的功能障碍有关,还与参与嗅觉处理的多个脑区的变化有关。具体来说,眶额皮层被认为在整合嗅觉信息方面起着关键作用,它与嗅觉皮层、杏仁核和内侧皮层等主要嗅觉区域进行双向交流。然而,人们对嗅觉失调症患者这些脑区之间结构连接的改变知之甚少。在这项研究中,研究人员获得了参与者的高分辨率 T1 加权图像。利用与嗅觉功能有关联的关键脑区的体积,我们采用结构协方差方法研究了与健康人(人数=30)相比,嗜嗅症患者(人数=22)的大脑重组模式。我们的结构协方差分析表明,与健康人相比,主要嗅觉网络的组成部分杏仁核和内嗅皮层之间的连通性减弱(z=-2.22,FDR 校正 p=0.039)。相反,与健康人相比,嗜嗅症组患者的眶额皮层--扩展嗅觉网络的主要区域--与杏仁核之间的连接性增强(z=2.32,FDR校正后p=0.039)。然而,眶额皮层和内侧皮层之间的结构连接在组间没有显著差异(z=0.04,FDR校正后p=0.968)。这些研究结果表明,在嗅觉缺失的个体中,可能存在结构重组,尤其是高阶皮层区域的结构重组,这可能是为了解释有限的嗅觉信息而做出的补偿性努力。
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Changes in Structural Covariance among Olfactory-related Brain Regions in Anosmia Patients.

Anosmia, characterized by the loss of smell, is associated not only with dysfunction in the peripheral olfactory system but also with changes in several brain regions involved in olfactory processing. Specifically, the orbitofrontal cortex is recognized for its pivotal role in integrating olfactory information, engaging in bidirectional communication with the primary olfactory regions, including the olfactory cortex, amygdala, and entorhinal cortex. However, little is known about alterations in structural connections among these brain regions in patients with anosmia. In this study, high-resolution T1-weighted images were obtained from participants. Utilizing the volumes of key brain regions implicated in olfactory function, we employed a structural covariance approach to investigate brain reorganization patterns in patients with anosmia (n=22) compared to healthy individuals (n=30). Our structural covariance analysis demonstrated diminished connectivity between the amygdala and entorhinal cortex, components of the primary olfactory network, in patients with anosmia compared to healthy individuals (z=-2.22, FDR-corrected p=0.039). Conversely, connectivity between the orbitofrontal cortex-a major region in the extended olfactory network-and amygdala was found to be enhanced in the anosmia group compared to healthy individuals (z=2.32, FDR-corrected p=0.039). However, the structural connections between the orbitofrontal cortex and entorhinal cortex did not differ significantly between the groups (z=0.04, FDR-corrected p=0.968). These findings suggest a potential structural reorganization, particularly of higher-order cortical regions, possibly as a compensatory effort to interpret the limited olfactory information available in individuals with olfactory loss.

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来源期刊
Experimental Neurobiology
Experimental Neurobiology Neuroscience-Cellular and Molecular Neuroscience
CiteScore
4.30
自引率
4.20%
发文量
29
期刊介绍: Experimental Neurobiology is an international forum for interdisciplinary investigations of the nervous system. The journal aims to publish papers that present novel observations in all fields of neuroscience, encompassing cellular & molecular neuroscience, development/differentiation/plasticity, neurobiology of disease, systems/cognitive/behavioral neuroscience, drug development & industrial application, brain-machine interface, methodologies/tools, and clinical neuroscience. It should be of interest to a broad scientific audience working on the biochemical, molecular biological, cell biological, pharmacological, physiological, psychophysical, clinical, anatomical, cognitive, and biotechnological aspects of neuroscience. The journal publishes both original research articles and review articles. Experimental Neurobiology is an open access, peer-reviewed online journal. The journal is published jointly by The Korean Society for Brain and Neural Sciences & The Korean Society for Neurodegenerative Disease.
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