利用 LC-MS/MS 和 LC-HRMS 同时耦合 ICP-MS，测定食品接触材料中的可萃取有机氟 (EOF) 总量，并对全氟和多氟烷基物质进行目标和非目标分析。

IF 2.3 3区农林科学 Q2 CHEMISTRY, APPLIED Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment Pub Date : 2024-07-01 Epub Date: 2024-05-10 DOI:10.1080/19440049.2024.2347491

Tengetile Nxumalo, Abdullah Akhdhar, Viktoria Müller, Amnah Al Zbedy, Andrea Raab, Milica Jovanovic, Erich Leitner, Andrew Kindness, Jörg Feldmann

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引用次数: 0

摘要

对来自三个国家的食品接触材料（FCMs）进行了分析，以检测材料中的所有可萃取有机氟（EOFs），然后通过目标和非目标分析检测全氟和多氟烷基物质（PFAS）。英国和沙特阿拉伯的含氟聚合物的 EOF 值相差两个数量级，介于 2.14 和 483 纳克 cm-2 之间（0.2-48 纳克 g-1），表明四分之一的样品超过了丹麦对含氟聚合物中 PFAS 的规定。目标全氟辛烷磺酸的成分变化很大，占 EOF 的比例不到 1%。使用 HPLC-ICP-MS 并同时结合 HRMS 进行的非目标 PFAS 筛选显示，存在 LC-MS/MS 和 LC-HRMS 都无法识别的有机氟。这说明当前的目标 PFAS 方法无法从 FCM 中识别出 EOF，这将成为欧盟禁止所有 PFAS 的新提案中的一个问题。

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Determination of total extractable organofluorine (EOF) in food contact materials and target and non-target analysis of per- and polyfluoroalkyl substances using LC-MS/MS and LC-HRMS simultaneously coupled to ICP-MS.

Food contact materials (FCMs) from three countries were analysed for all extractable organofluorines (EOFs) from the materials and subsequently by target and non-target analysis for per- and polyfluoroalkyl substances (PFAS). The EOF varied by two orders of magnitude for FCM from UK and Saudi Arabia ranging between 2.14 and 483 ng cm^-2 (0.2-48 ng g^-1) showing that one quarter of all samples were above the Danish regulation for PFAS in FCM. Target PFAS showed high variability in composition and accounted for less than 1% of the EOF. Non-target PFAS screening using HPLC-ICP-MS and coupled simultaneously to HRMS showed the occurrence of organofluorines which were identified by neither LC-MS/MS nor LC-HRMS. This illustrates that the current target PFAS approaches fail to identify EOFs from FCM, which would be a problem with the new EU proposal to ban all PFAS.

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来源期刊

Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment CHEMISTRY, APPLIED-FOOD SCIENCE & TECHNOLOGY

CiteScore

7.40

自引率

6.90%

发文量

136

审稿时长

3 months

期刊介绍： Food Additives & Contaminants: Part A publishes original research papers and critical reviews covering analytical methodology, occurrence, persistence, safety evaluation, detoxification and regulatory control of natural and man-made additives and contaminants in the food and animal feed chain. Papers are published in the areas of food additives including flavourings, pesticide and veterinary drug residues, environmental contaminants, plant toxins, mycotoxins, marine biotoxins, trace elements, migration from food packaging, food process contaminants, adulteration, authenticity and allergenicity of foods. Papers are published on animal feed where residues and contaminants can give rise to food safety concerns. Contributions cover chemistry, biochemistry and bioavailability of these substances, factors affecting levels during production, processing, packaging and storage; the development of novel foods and processes; exposure and risk assessment.