作为人类疗法的细胞外囊泡:文献综述。

IF 15.5 1区 医学 Q1 CELL BIOLOGY Journal of Extracellular Vesicles Pub Date : 2024-05-13 DOI:10.1002/jev2.12433
Clorinda Fusco, Giusy De Rosa, Ilaria Spatocco, Elisabetta Vitiello, Claudio Procaccini, Chiara Frigè, Valeria Pellegrini, Rosalba La Grotta, Roberto Furlan, Giuseppe Matarese, Francesco Prattichizzo, Paola de Candia
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引用次数: 0

摘要

细胞外囊泡 (EV) 由所有细胞释放,有助于细胞间的交流。由于细胞外囊泡具有靶向特定细胞和高效传递功能分子复合特征的能力,世界各地的研究人员都在假设它们作为治疗药物的潜力。尽管在动物模型中对 EV 治疗进行了大量研究,但其对人类的实际临床益处却迟迟未得到验证。在这次范围界定综述中,我们检索了 PubMed 和其他数据库(截至 2023 年 12 月 31 日),从 13,567 条记录中选出了 40 项相关的已发表研究,测试 EVs 作为人类疗法的效果。对这 40 项研究的分析表明,它们都是小型试验,在给药途径和目标疾病方面存在很大的异质性。此外,大多数研究都没有安慰剂对照,EV制剂主要用于局部,给药剂量指标也不一致,这些都妨碍了对不同研究进行比较,也无法就EV的安全性和有效性得出确切结论。另一方面,一些有希望的结果也强烈呼吁进行精心设计的更大规模研究,以测试 EV 作为治疗人类疾病的替代方法,而目前还没有或只有很少的治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Extracellular vesicles as human therapeutics: A scoping review of the literature

Extracellular vesicles (EVs) are released by all cells and contribute to cell-to-cell communication. The capacity of EVs to target specific cells and to efficiently deliver a composite profile of functional molecules have led researchers around the world to hypothesize their potential as therapeutics. While studies of EV treatment in animal models are numerous, their actual clinical benefit in humans has more slowly started to be tested. In this scoping review, we searched PubMed and other databases up to 31 December 2023 and, starting from 13,567 records, we selected 40 pertinent published studies testing EVs as therapeutics in humans.

The analysis of those 40 studies shows that they are all small pilot trials with a large heterogeneity in terms of administration route and target disease. Moreover, the absence of a placebo control in most of the studies, the predominant local application of EV formulations and the inconsistent administration dose metric still impede comparison across studies and firm conclusions about EV safety and efficacy. On the other hand, the recording of some promising outcomes strongly calls out for well-designed larger studies to test EVs as an alternative approach to treat human diseases with no or few therapeutic options.

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来源期刊
Journal of Extracellular Vesicles
Journal of Extracellular Vesicles Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
27.30
自引率
4.40%
发文量
115
审稿时长
12 weeks
期刊介绍: The Journal of Extracellular Vesicles is an open access research publication that focuses on extracellular vesicles, including microvesicles, exosomes, ectosomes, and apoptotic bodies. It serves as the official journal of the International Society for Extracellular Vesicles and aims to facilitate the exchange of data, ideas, and information pertaining to the chemistry, biology, and applications of extracellular vesicles. The journal covers various aspects such as the cellular and molecular mechanisms of extracellular vesicles biogenesis, technological advancements in their isolation, quantification, and characterization, the role and function of extracellular vesicles in biology, stem cell-derived extracellular vesicles and their biology, as well as the application of extracellular vesicles for pharmacological, immunological, or genetic therapies. The Journal of Extracellular Vesicles is widely recognized and indexed by numerous services, including Biological Abstracts, BIOSIS Previews, Chemical Abstracts Service (CAS), Current Contents/Life Sciences, Directory of Open Access Journals (DOAJ), Journal Citation Reports/Science Edition, Google Scholar, ProQuest Natural Science Collection, ProQuest SciTech Collection, SciTech Premium Collection, PubMed Central/PubMed, Science Citation Index Expanded, ScienceOpen, and Scopus.
期刊最新文献
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