评估间质性膀胱炎/膀胱疼痛综合征患者的症状严重程度和尿液细胞因子水平,包括有无亨纳病变。

IF 1.5 Q3 UROLOGY & NEPHROLOGY American journal of clinical and experimental urology Pub Date : 2024-04-15 eCollection Date: 2024-01-01 DOI:10.62347/BLED2401
Bernadette Mm Zwaans, Sabrina Mota, Sarah N Bartolone, Elijah P Ward, Kenneth M Peters, Michael B Chancellor
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引用次数: 0

摘要

目的:间质性膀胱炎/膀胱疼痛综合征(IC/BPS)的部分特征是尿急、尿频和尿痛。人们对收集更多数据以比较和评估IC/BPS患者因Hunner病变而产生的特征差异有着浓厚的兴趣:我们通过全国范围内的众包努力,收集了有 IC/BPS 病史患者的调查问卷和尿样。参与者填写了间质性膀胱炎症状指数(ICSI)和问题指数(ICPI)、膀胱过度活动问卷(OABq SF)和疼痛评分。此外,参与者还报告了任何并发症和生活方式改变情况。测量尿液细胞因子水平并与症状严重程度进行比较:结果:491 人参加了研究:119 人有溃疡性亨纳病变史(UIC),372 人报告无病变(NHIC),2 人情况不明。96.3%为女性,男女溃疡性亨纳氏病变发病率相同。UIC 组的平均年龄高于 NHIC 组(P = 0.011),确诊时间也高于 NHIC 组(P < 0.001)。UIC 患者的症状评分较高(P < 0.001)。两组患者都广泛采用了改变生活方式的方法,其中以改变饮食习惯最为普遍(70.1%),其次是使用处方药(63.1%)。与国家卫生信息中心的参与者相比,有更多的尿毒症患者合并有其他疾病(P = 0.010)。对尿液样本进行了 GRO、IL-6、IL-8 和 MCP-1 分析。UIC 患者的 MCP-1 水平明显更高(P = 0.044)。细胞因子与症状评分之间存在微弱的正相关性:结论:美国各地的 UIC 和 NHIC 患者表现出不同的表型和尿液生物学特征。这些发现有助于加深对 IC/BPS 的了解,并有助于提高我们对该疾病的认识。
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Evaluating symptom severity and urinary cytokine levels in interstitial cystitis/bladder pain syndrome patients, with and without Hunner's lesions.

Purpose: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a condition characterized in part by urinary urgency, frequency, and pain. There is a strong interest in gathering more data to compare and assess the differences in characteristics based on the presence of Hunner's lesions in patients with IC/BPS.

Materials and methods: Using a nationwide crowdsource effort, we collected surveys and urine samples from patients with a history of IC/BPS. Participants completed the Interstitial Cystitis Symptom Index (ICSI) and Problem Index (ICPI), Overactive Bladder questionnaire (OABq SF), and pain scores. In addition, participants reported any co-morbidities and lifestyle modifications. Urinary cytokine levels were measured and compared to symptom severity.

Results: 491 participants enrolled: 119 with history of ulcerative Hunner's lesions (UIC), 372 reported no lesions (NHIC), and 2 unknowns. 96.3% were female, and prevalence of UIC was equal for both genders. Average age was higher for UIC vs. NHIC group (P = 0.011), as was the duration since diagnosis (P < 0.001). Symptom scores were elevated in UIC patients (P < 0.001). Both groups widely implemented lifestyle modifications, with dietary changes being most prevalent (70.1%), followed by prescription medication usage (63.1%). More UIC compared to NHIC participants experienced co-morbidities (P = 0.010). Urine samples were analyzed for GRO, IL-6, IL-8, and MCP-1. MCP-1 levels were significantly higher in UIC patients (P = 0.044). Weak positive correlation was found between cytokines and symptom scores.

Conclusions: Patients with UIC and NHIC from across the United States displayed distinct phenotypic and urine biological characteristics. These findings contribute to increased understanding of IC/BPS and may aid in improving our knowledge of the condition.

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