交感神经信号:乳腺发育和干细胞活力的协调者。

IF 5.3 2区 生物学 Q2 CELL BIOLOGY Journal of Molecular Cell Biology Pub Date : 2024-10-21 DOI:10.1093/jmcb/mjae020
Zi Ye, Yu Xu, Mengna Zhang, Cheguo Cai
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引用次数: 0

摘要

乳腺是一个动态器官,在产后发育的多个阶段都会发生重大变化。尽管对全身激素和微环境线索在乳腺稳态中的作用进行了广泛的研究,但对神经信号,尤其是交感神经系统信号的影响仍然知之甚少。在此,我们利用小鼠乳腺模型,深入研究了交感神经信号在乳腺干细胞和乳腺发育中的调控作用。我们的研究结果表明,交感神经信号的耗竭会导致青春期、成年期和妊娠期乳腺发育缺陷,并伴随着乳腺干细胞数量的减少。通过体外三维培养和体内移植分析,我们证明交感神经信号的缺失阻碍了乳腺干细胞的自我更新和再生,而交感神经信号的激活则促进了这些能力。从机制上讲,交感神经信号通过ERK信号通路协调乳腺干细胞活性和乳腺发育。总之,我们的研究揭示了交感神经信号在维持乳腺发育和调节乳腺干细胞活性中的关键作用,为神经系统参与调节成体干细胞功能和器官发育提供了一个新的视角。
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Sympathetic nerve signals: orchestrators of mammary development and stem cell vitality.

The mammary gland is a dynamic organ that undergoes significant changes at multiple stages of postnatal development. Although the roles of systemic hormones and microenvironmental cues in mammary homeostasis have been extensively studied, the influence of neural signals, particularly those from the sympathetic nervous system, remains poorly understood. Here, using a mouse mammary gland model, we delved into the regulatory role of sympathetic nervous signaling in the context of mammary stem cells and mammary development. Our findings revealed that depletion of sympathetic nerve signals results in defective mammary development during puberty, adulthood, and pregnancy, accompanied by a reduction in mammary stem cell numbers. Through in vitro three-dimensional culture and in vivo transplantation analyses, we demonstrated that the absence of sympathetic nerve signals hinders mammary stem cell self-renewal and regeneration, while activation of sympathetic nervous signaling promotes these capacities. Mechanistically, sympathetic nerve signals orchestrate mammary stem cell activity and mammary development through the extracellular signal-regulated kinase signaling pathway. Collectively, our study unveils the crucial roles of sympathetic nerve signals in sustaining mammary development and regulating mammary stem cell activity, offering a novel perspective on the involvement of the nervous system in modulating adult stem cell function and organ development.

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来源期刊
CiteScore
9.60
自引率
1.80%
发文量
1383
期刊介绍: The Journal of Molecular Cell Biology ( JMCB ) is a full open access, peer-reviewed online journal interested in inter-disciplinary studies at the cross-sections between molecular and cell biology as well as other disciplines of life sciences. The broad scope of JMCB reflects the merging of these life science disciplines such as stem cell research, signaling, genetics, epigenetics, genomics, development, immunology, cancer biology, molecular pathogenesis, neuroscience, and systems biology. The journal will publish primary research papers with findings of unusual significance and broad scientific interest. Review articles, letters and commentary on timely issues are also welcome. JMCB features an outstanding Editorial Board, which will serve as scientific advisors to the journal and provide strategic guidance for the development of the journal. By selecting only the best papers for publication, JMCB will provide a first rate publishing forum for scientists all over the world.
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