利用蛋白质组学信息外流比-相关表达因子（ER-REF）方法和 PBPK 建模与模拟，预测和验证胎儿暴露于 BCRP/P-GP 双药物底物的情况

{"title":"利用蛋白质组学信息外流比-相关表达因子（ER-REF）方法和 PBPK 建模与模拟，预测和验证胎儿暴露于 BCRP/P-GP 双药物底物的情况","authors":"Ankit Balhara","doi":"10.1016/j.dmpk.2023.100809","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"55 ","pages":"Article 100809"},"PeriodicalIF":2.7000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prediction and validation of fetal exposure to dual BCRP/P-GP drug substrates using the proteomics informed efflux ratio-relative expression factor (ER-REF) approach and PBPK modeling and simulation\",\"authors\":\"Ankit Balhara\",\"doi\":\"10.1016/j.dmpk.2023.100809\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":11298,\"journal\":{\"name\":\"Drug Metabolism and Pharmacokinetics\",\"volume\":\"55 \",\"pages\":\"Article 100809\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug Metabolism and Pharmacokinetics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S134743672300321X\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Metabolism and Pharmacokinetics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S134743672300321X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}