{"title":"基于 TFET 的新型纳米隙高灵敏度生物传感器,可靠性更高--灵敏度定义的新指标","authors":"Mohammad K. Anvarifard , Zeinab Ramezani","doi":"10.1016/j.physe.2024.115998","DOIUrl":null,"url":null,"abstract":"<div><p>This is a detailed report about the proposal of an efficient nanogap dielectrically modulated tunnel field-effect transistor (TFET) biodevice granting a high sensitivity in the detection of the targeted biomolecules while keeping high performance in the realistic situations with boosting the reliability. Two attractive approaches in the cases of the bandgap engineering and charge plasma concept have been suggested for the band energy correction increasing the sensing current and the sensitivity without occurrence possibility of fabrication process related issues as compared to common TFET and PNPN TFET biosensors. The streptavidin, biotin and APTES samples have been selected as typical biomolecules for the sensing performance comparison of the biosensors under the study. Also, the proposed biosensor showed performance superiority for other biomolecules. For the first time, a new metric for measuring sensitivity is proposed to combine both maximum current sensitivity and well-defined average sensitivity in a unique relation named effective sensitivity. This prevents the possible noise impact on the sensitivity of the biosensors since the TFET based biosensors suffer from the low detection current. Defining the effective sensitivity, the proposed biosensor has been evaluated in more realistic conditions including partial hybridization of biomolecules inside the nanogap, trap-assisted-tunneling (TAT) component, neutral/charged biomolecules and biomolecules accumulation in different orientations showing the performance superiority of the proposed biosensor.</p></div>","PeriodicalId":20181,"journal":{"name":"Physica E-low-dimensional Systems & Nanostructures","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A novel TFET based nanogap high-sensitive biosensor by boosted reliability- new metric for sensitivity definition\",\"authors\":\"Mohammad K. Anvarifard , Zeinab Ramezani\",\"doi\":\"10.1016/j.physe.2024.115998\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This is a detailed report about the proposal of an efficient nanogap dielectrically modulated tunnel field-effect transistor (TFET) biodevice granting a high sensitivity in the detection of the targeted biomolecules while keeping high performance in the realistic situations with boosting the reliability. Two attractive approaches in the cases of the bandgap engineering and charge plasma concept have been suggested for the band energy correction increasing the sensing current and the sensitivity without occurrence possibility of fabrication process related issues as compared to common TFET and PNPN TFET biosensors. The streptavidin, biotin and APTES samples have been selected as typical biomolecules for the sensing performance comparison of the biosensors under the study. Also, the proposed biosensor showed performance superiority for other biomolecules. For the first time, a new metric for measuring sensitivity is proposed to combine both maximum current sensitivity and well-defined average sensitivity in a unique relation named effective sensitivity. This prevents the possible noise impact on the sensitivity of the biosensors since the TFET based biosensors suffer from the low detection current. Defining the effective sensitivity, the proposed biosensor has been evaluated in more realistic conditions including partial hybridization of biomolecules inside the nanogap, trap-assisted-tunneling (TAT) component, neutral/charged biomolecules and biomolecules accumulation in different orientations showing the performance superiority of the proposed biosensor.</p></div>\",\"PeriodicalId\":20181,\"journal\":{\"name\":\"Physica E-low-dimensional Systems & Nanostructures\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-05-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physica E-low-dimensional Systems & Nanostructures\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1386947724001024\",\"RegionNum\":3,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NANOSCIENCE & NANOTECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physica E-low-dimensional Systems & Nanostructures","FirstCategoryId":"101","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1386947724001024","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NANOSCIENCE & NANOTECHNOLOGY","Score":null,"Total":0}
A novel TFET based nanogap high-sensitive biosensor by boosted reliability- new metric for sensitivity definition
This is a detailed report about the proposal of an efficient nanogap dielectrically modulated tunnel field-effect transistor (TFET) biodevice granting a high sensitivity in the detection of the targeted biomolecules while keeping high performance in the realistic situations with boosting the reliability. Two attractive approaches in the cases of the bandgap engineering and charge plasma concept have been suggested for the band energy correction increasing the sensing current and the sensitivity without occurrence possibility of fabrication process related issues as compared to common TFET and PNPN TFET biosensors. The streptavidin, biotin and APTES samples have been selected as typical biomolecules for the sensing performance comparison of the biosensors under the study. Also, the proposed biosensor showed performance superiority for other biomolecules. For the first time, a new metric for measuring sensitivity is proposed to combine both maximum current sensitivity and well-defined average sensitivity in a unique relation named effective sensitivity. This prevents the possible noise impact on the sensitivity of the biosensors since the TFET based biosensors suffer from the low detection current. Defining the effective sensitivity, the proposed biosensor has been evaluated in more realistic conditions including partial hybridization of biomolecules inside the nanogap, trap-assisted-tunneling (TAT) component, neutral/charged biomolecules and biomolecules accumulation in different orientations showing the performance superiority of the proposed biosensor.
期刊介绍:
Physica E: Low-dimensional systems and nanostructures contains papers and invited review articles on the fundamental and applied aspects of physics in low-dimensional electron systems, in semiconductor heterostructures, oxide interfaces, quantum wells and superlattices, quantum wires and dots, novel quantum states of matter such as topological insulators, and Weyl semimetals.
Both theoretical and experimental contributions are invited. Topics suitable for publication in this journal include spin related phenomena, optical and transport properties, many-body effects, integer and fractional quantum Hall effects, quantum spin Hall effect, single electron effects and devices, Majorana fermions, and other novel phenomena.
Keywords:
• topological insulators/superconductors, majorana fermions, Wyel semimetals;
• quantum and neuromorphic computing/quantum information physics and devices based on low dimensional systems;
• layered superconductivity, low dimensional systems with superconducting proximity effect;
• 2D materials such as transition metal dichalcogenides;
• oxide heterostructures including ZnO, SrTiO3 etc;
• carbon nanostructures (graphene, carbon nanotubes, diamond NV center, etc.)
• quantum wells and superlattices;
• quantum Hall effect, quantum spin Hall effect, quantum anomalous Hall effect;
• optical- and phonons-related phenomena;
• magnetic-semiconductor structures;
• charge/spin-, magnon-, skyrmion-, Cooper pair- and majorana fermion- transport and tunneling;
• ultra-fast nonlinear optical phenomena;
• novel devices and applications (such as high performance sensor, solar cell, etc);
• novel growth and fabrication techniques for nanostructures