Zhen-Yuan Liu, Feng Tang, Jin-Zhou Yang, Xi Chen, Ze-Fen Wang, Zhi-Qiang Li
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引用次数: 0
摘要
中枢神经系统(CNS)疾病是导致残疾的主要原因,也是全球第二大死因,给社会造成了巨大的经济负担。近年来,新的证据发现,主要组织相容性复合体 I 类(MHC-I)分子的一个亚基--β2-微球蛋白(B2M)在某些中枢神经系统疾病的发生和发展中起着至关重要的作用。一方面,细胞内 B2M 在脑肿瘤中异常上调,并调控肿瘤的微环境和进展。另一方面,可溶性 B2M 也会升高,并参与中枢神经系统疾病的病理阶段。B2M 靶向治疗在特定中枢神经系统疾病中显示出良好的疗效。在这篇综述中,我们将全面总结和讨论中枢神经系统疾病(如阿尔茨海默病、衰老、中风、艾滋病相关痴呆、胶质瘤和原发性中枢神经系统淋巴瘤)中涉及 B2M 的病理过程的最新进展。
The Role of Beta2-Microglobulin in Central Nervous System Disease.
Central nervous system (CNS) disorders represent the leading cause of disability and the second leading cause of death worldwide, and impose a substantial economic burden on society. In recent years, emerging evidence has found that beta2 -microglobulin (B2M), a subunit of major histocompatibility complex class I (MHC-I) molecules, plays a crucial role in the development and progression in certain CNS diseases. On the one hand, intracellular B2M was abnormally upregulated in brain tumors and regulated tumor microenvironments and progression. On the other hand, soluble B2M was also elevated and involved in pathological stages in CNS diseases. Targeted B2M therapy has shown promising outcomes in specific CNS diseases. In this review, we provide a comprehensive summary and discussion of recent advances in understanding the pathological processes involving B2M in CNS diseases (e.g., Alzheimer's disease, aging, stroke, HIV-related dementia, glioma, and primary central nervous system lymphoma).
期刊介绍:
Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.