印度泰米尔纳德邦 Tiruvannamalai 区 Jawadhu 山马拉雅族部落中血红蛋白病的患病率:一项基于社区的横断面研究。

IF 2 4区 医学 Q3 HEMATOLOGY Hematology Pub Date : 2024-12-01 Epub Date: 2024-05-14 DOI:10.1080/16078454.2024.2350320
Balasubramanian Ganesh, Thangarasu Rajakumar, Subhendu Kumar Acharya, Shanmugasundaram Devika, Venkatachalam Ramachandran, Jayaram Yuvaraj, Anita Nadkarni, Shanmugam Rajasubramaniam, Harpreet Kaur
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引用次数: 0

摘要

背景:血红蛋白(Hb)是红细胞(RBC)中的一种红色色素,可将氧气从肺部运送到身体的不同器官,并将二氧化碳运送回肺部。血红蛋白结构中的任何缺陷都会导致红细胞产生不良的功能影响,如镰状细胞性贫血(SCA)、地中海贫血症等。在全球发达国家和发展中国家,约有 7% 的人患有血红蛋白病。本研究旨在确定血红蛋白病(包括镰状细胞性贫血、地中海贫血和其他异常 Hb 变异)在印度泰米尔纳德邦蒂鲁凡纳马莱地区 Jawadhu 山的马拉雅部落中的流行率和携带者频率:从 2022 年 7 月到 2022 年 9 月,对居住在蒂鲁凡纳马莱地区 Jawadhu 山的 443 个马拉雅族部落进行了社区横断面研究。根据标准方案,使用全自动 5 部分血液分析仪(Mindray, BC-5150)分析红细胞指数,并使用高效液相色谱系统(Bio-Rad, D-10)进行血红蛋白分馏:共筛查了 443 名参与者,其中 14.67% 的人血红蛋白分数异常,83.30% 的人血红蛋白分数正常,2.03% 的人血红蛋白分数处于边缘状态。值得注意的是,研究显示α地中海贫血特质的发病率为 0.68%,β地中海贫血特质的发病率为 13.99%:血红蛋白病,尤其是β-地中海贫血症,在居住在提鲁凡纳马莱地区贾瓦杜山的泰米尔纳德邦马拉雅部落人口中最为普遍。因此,我们需要政府和非政府组织(NGOs)特别关注提高认识,增加血红蛋白病筛查项目,提高对部落健康状况的重视程度,以改善少数民族部落的状况。
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Prevalence of hemoglobinopathies among Malayali tribes of Jawadhu hills, Tiruvannamalai district, Tamil Nadu, India: a community-based cross-sectional study.

Background: Hemoglobin (Hb), a red pigment of red blood cells (RBCs), carries oxygen from the lungs to different organs of the body and transports carbon dioxide back to the lungs. Any fault present in the Hb structure leads to undesirable functional effects of the RBCs, such as sickle cell anemia (SCA), thalassemia, etc. Hemoglobinopathies affect around 7% of people in both developed and developing countries globally. The aim of the present study was to determine the prevalence and carrier frequencies of hemoglobinopathies including SCA, thalassemia, and other abnormal Hb variants among Malayali tribes in the Jawadhu hills of Tiruvannamalai district, Tamil Nadu, India.

Methods: A community-based cross-sectional study was carried out among 443 Malayali tribes inhabiting the Jawadhu hills of Tiruvannamalai district from July 2022 to September 2022. The RBC indices were analyzed using an automated 5-part hematology analyzer (Mindray, BC-5150) and hemoglobin fractions were done using the HPLC system (Bio-Rad, D-10) following standard protocols.

Findings: A total of 443 participants were screened, out of whom 14.67% had an abnormal Hb fraction, 83.30% were identified as normal, and 2.03% were borderline. Notably, the study revealed a prevalence of 0.68% for the α-thalassemia trait and 13.99% for the β-thalassemia trait.

Interpretation: Haemoglobinopathies, specifically the β-thalassemia trait, were most prevalent among the Malayali tribal population of Tamil Nadu residing in the Jawadhu hills of Tiruvannamalai district. Hence, we need special attention for creating awareness, increasing hemoglobinopathies screening programs, and improving the importance of tribal health conditions by the government and non-governmental organizations (NGOs) for the betterment of the ethnic tribes.

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来源期刊
Hematology
Hematology 医学-血液学
CiteScore
2.60
自引率
5.30%
发文量
140
审稿时长
3 months
期刊介绍: Hematology is an international journal publishing original and review articles in the field of general hematology, including oncology, pathology, biology, clinical research and epidemiology. Of the fixed sections, annotations are accepted on any general or scientific field: technical annotations covering current laboratory practice in general hematology, blood transfusion and clinical trials, and current clinical practice reviews the consensus driven areas of care and management.
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