糖尿病的细胞疗法和基因疗法:当前进展。

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Current diabetes reviews Pub Date : 2024-05-13 DOI:10.2174/0115733998292392240425122326
Leila Ghassemifard, Masumeh Hasanlu, Negin Parsamanesh, Stephen L Atkin, Wael Almahmeed, Amirhossein Sahebkar
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引用次数: 0

摘要

糖尿病的流行仍是一个日益严重的问题,因此需要新的治疗策略。目前,合成药物化学领域正在开发几种治疗糖尿病的药物和分子。除此以外,基因和细胞疗法也在进行广泛的研究。基因疗法是治疗癌症、自身免疫性疾病、心脏病和糖尿病等多种疾病的现有方法。一些报告还指出,干细胞具有分化能力,可在体外和体内促进胰腺β细胞的功能发育,可用于治疗糖尿病和预防糖尿病相关并发症的恶化。在本综述中,我们重点讨论了不同类型的细胞疗法和载体基因疗法在治疗或预防糖尿病方面的应用。
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Cell Therapies and Gene Therapy for Diabetes: Current Progress.

The epidemic of diabetes continues to be an increasing problem, and there is a need for new therapeutic strategies. There are several promising drugs and molecules in synthetic medicinal chemistry that are developing for diabetes. In addition to this approach, extensive studies with gene and cell therapies are being conducted. Gene therapy is an existing approach in treating several diseases, such as cancer, autoimmune diseases, heart disease and diabetes. Several reports have also suggested that stem cells have the differentiation capability to functional pancreatic beta cell development in vitro and in vivo, with the utility to treat diabetes and prevent the progression of diabetes-related complications. In this current review, we have focused on the different types of cell therapies and vector-based gene therapy in treating or preventing diabetes.

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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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