Qifu Hong, Tao Pu, Maojie Li, Zhongbao Chen, Xingyan Liu, Rong Zeng, Mingzhe Zhang, Lulu Dai, Songlin An, Xubo Shen, Xuejun Shang, Yuanzhong Zhou, Kunming Tian
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引用次数: 0
摘要
邻苯二甲酸盐代谢物与孕妇血清尿酸(SUA)水平升高之间的关系尚不明确。为此,我们对中国西南地区遵义出生队列中的 851 名孕妇进行了一项基于人群的横断面研究。研究采用多元线性回归模型探讨了十种尿液中邻苯二甲酸酯代谢物与 SUA 和估计肾小球滤过率(eGFR)之间的单一关系。然后,通过主成分分析(PCA)和量子g计算(Q-g)分析确定了邻苯二甲酸酯混合物与SUA和eGFR的整体关系。多变量线性回归结果显示,邻苯二甲酸单丁酯(MBP)、邻苯二甲酸单辛酯(MOP)和邻苯二甲酸单苄酯(MBzP)与 SUA 呈正相关,而邻苯二甲酸单(2-乙基己基)酯(MEHP)和邻苯二甲酸单(2-乙基-5-羟基己基)酯(MEHHP)与 eGFR 水平升高相关。此外,PCA 分析表明,邻苯二甲酸酯混合物与 SUA 呈正相关,而 MOP、MBzP 和 MEHP 似乎是主要的促成因素。此外,Q-g 回归显示,邻苯二甲酸酯混合物每增加一个量级,SUA 就会增加 3.27%(95% CI 0.21%,6.41%)。我们的结果表明,邻苯二甲酸酯代谢物与晚期孕妇较高的 SUA 有关,而 MBP、MBzP 和 MOP 可能是主要的驱动因素。因此,应认真对待围产期健康问题,以应对与环境有关的肾功能失调。
Association between urinary phthalate metabolites and renal function in late pregnant women
Evidence about associations of phthalates metabolites with increased serum uric acid (SUA) levels in pregnant women remains unknown. To address this, we conducted a cross-sectional population-based study including 851 pregnant women from Zunyi birth cohort in southwest China. Multiple linear regression models were used to explore single relationships between ten urinary phthalate metabolites with SUA and estimated glomerular filtration rate (eGFR). And then, the overall relationship of phthalate mixture with SUA and eGFR were determined by principal component analysis (PCA) and quantile g-computation (Q-g) analysis. The multivariable linear regression showed that mono-butyl phthalate (MBP), mono-octyl phthalate (MOP) and mono-benzyl phthalate (MBzP) were positively associated with SUA, while mono (2-ethylhexyl) phthalate (MEHP) and mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) were associated with increased eGFR level. Moreover, PCA analysis suggested that phthalate mixture was positively associated with SUA, and MOP, MBzP and MEHP appeared to be the major contributors. Furthermore, Q-g regression showed that each quantile increase in phthalate mixture was associated with 3.27% higher SUA (95% CI 0.21%, 6.41%). Our results imply that phthalate metabolites were associated with higher SUA in late pregnant women, and MBP, MBzP and MOP might be the major drivers. So, a health perinatal duration should be seriously taken to counteract the environment-related dysregulated kidney function.
期刊介绍:
ESEU is an international journal, focusing primarily on Europe, with a broad scope covering all aspects of environmental sciences, including the main topic regulation.
ESEU will discuss the entanglement between environmental sciences and regulation because, in recent years, there have been misunderstandings and even disagreement between stakeholders in these two areas. ESEU will help to improve the comprehension of issues between environmental sciences and regulation.
ESEU will be an outlet from the German-speaking (DACH) countries to Europe and an inlet from Europe to the DACH countries regarding environmental sciences and regulation.
Moreover, ESEU will facilitate the exchange of ideas and interaction between Europe and the DACH countries regarding environmental regulatory issues.
Although Europe is at the center of ESEU, the journal will not exclude the rest of the world, because regulatory issues pertaining to environmental sciences can be fully seen only from a global perspective.