Maria Ricci, Silvia Scriffignano, Fabio Massimo Perrotta, Bruno Carabellese, Maria Rosaria Grivet Fojaja, Andrea Cimini, Ennio Lubrano
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The aim of this review is to explore the role of PET imaging in psoriasis and psoriatic arthritis, especially in the assessment of joint and systemic inflammation and vascular inflammation, such as aortitis.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>We conducted an unstructured search of the literature for any studies employing the f [<sup>18</sup>F]-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG PET/CT) in the assessment of inflammation in patients with psoriasis or psoriatic arthritis.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The role of [<sup>18</sup>F]-FDG PET/CT has been explored, with special focus on potential novel biomarkers, assessment of disease severity, and the imaging monitoring and validation of novel therapeutic strategies, including also future perspectives concerning further PET tracers, such as [<sup>18</sup>F]fluoride PET imaging.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>The possibility of the evaluation of inflammation in different sites can be used to evaluate both systemic, articular and periarticular inflammation, giving the possibility of a comprehensive assessment of the patients. 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引用次数: 0
摘要
目的 银屑病是一种影响皮肤和指甲的慢性自身免疫性炎症性疾病，但也可能涉及其他临床或亚临床炎症部位，包括关节。本综述旨在探讨 PET 成像在银屑病和银屑病关节炎中的作用，尤其是在评估关节和全身炎症以及血管炎症（如大动脉炎）中的作用。方法我们对文献进行了非结构化检索，以了解在评估银屑病或银屑病关节炎患者炎症时使用 [18F]-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG PET/CT) 的任何研究。结果探讨了[18F]-FDG PET/CT 的作用，重点是潜在的新型生物标记物、疾病严重程度评估、新型治疗策略的成像监测和验证，还包括有关其他 PET 示踪剂的未来展望，如[18F]氟 PET 成像。银屑病领域对新型生物标志物的新临床需求可能会在一些研究环境中得到 FDG PET 成像新型生物标志物的支持，但在临床实践中的应用还需要进一步的多中心试验。
PET imaging in the psoriasis and psoriatic arthritis field: un update
Purpose
Psoriasis is a chronic autoimmune inflammatory disease that affects skin and nails but may also involve further sites of clinical or subclinical inflammation, including the joints. The aim of this review is to explore the role of PET imaging in psoriasis and psoriatic arthritis, especially in the assessment of joint and systemic inflammation and vascular inflammation, such as aortitis.
Methods
We conducted an unstructured search of the literature for any studies employing the f [18F]-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG PET/CT) in the assessment of inflammation in patients with psoriasis or psoriatic arthritis.
Results
The role of [18F]-FDG PET/CT has been explored, with special focus on potential novel biomarkers, assessment of disease severity, and the imaging monitoring and validation of novel therapeutic strategies, including also future perspectives concerning further PET tracers, such as [18F]fluoride PET imaging.
Conclusions
The possibility of the evaluation of inflammation in different sites can be used to evaluate both systemic, articular and periarticular inflammation, giving the possibility of a comprehensive assessment of the patients. The emerging clinical needs for novel biomarkers in the psoriasis field can be potentially supported by novel biomarkers on FDG PET imaging in several research settings but further multicentric trials are needed for the implementation in the clinical practice.
期刊介绍：
Clinical and Translational Imaging is an international journal that publishes timely, up-to-date summaries on clinical practice and translational research and clinical applications of approved and experimental radiopharmaceuticals for diagnostic and therapeutic purposes. Coverage includes such topics as advanced preclinical evidence in the fields of physics, dosimetry, radiation biology and radiopharmacy with relevance to applications in human subjects. The journal benefits a readership of nuclear medicine practitioners and allied professionals involved in molecular imaging and therapy.
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