基于壳聚糖/pectin/NaCl 的聚电解质复合物水凝胶用于潜在伤口敷料:开发、表征和评估

IF 2.2 4区 化学 Q3 CHEMISTRY, PHYSICAL Colloid and Polymer Science Pub Date : 2024-05-08 DOI:10.1007/s00396-024-05261-y
Micaela Ferrante, Vera A. Alvarez, Liesel B. Gende, Diego Guerrieri, Eduardo Chuluyan, Jimena S. Gonzalez
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引用次数: 0

摘要

本研究通过形成聚电解质复合物(PECs)合成了基于壳聚糖、果胶和盐(NaCl)的水凝胶。研究人员改变了合成参数,包括 pH 值、盐度和聚合物浓度,以探讨它们的影响。重量和质地分析显示了水凝胶形态的差异。膨胀行为研究表明,pH 值为 4 时合成的水凝胶具有更高的膨胀能力。此外,盐的存在也影响了水凝胶的形成过程。热表征显示,第一个分解步骤发生在 180-224 °C 左右。使用扫描电子显微镜进行的形态测试突出显示了孔径和分布的差异,尤其是在配方中加入盐时(不含氯化钠时的孔壁直径为 2.2 ± 1.1 um,含氯化钠时为 4.7 ± 1.2 um)。包括 Zeta 电位、傅立叶变换红外光谱和 XRD 在内的物理化学测试深入揭示了水凝胶内部的相互作用:氢键和静电相互作用。此外,抗菌测试表明,水凝胶对大肠杆菌和金黄色葡萄球菌有效,不同的抑制程度与 NaCl 含量有关(不含 NaCl 时,大肠杆菌的光晕为 8 和 10 毫米;含 NaCl 时,为 10 和 15 毫米)。进一步的评估,包括水蒸气透过率(WVTR)和利多卡因释放试验,突出了水凝胶在伤口敷料应用方面的潜力,因为它具有合适的保湿性能和可控药物释放能力。含 0.15 M NaCl 的水凝胶的药物释放率高于不含盐的水凝胶(分别为 111.1% ± 9.5% 和 31.16% ± 15.13%)。初步的体内伤口愈合研究显示了良好的结果。总之,我们的研究结果强调了这些水凝胶的可调特性及其用于伤口敷料的潜力。
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Polyelectrolyte complexes hydrogels based on chitosan/pectin/NaCl for potentially wound dressing: development, characterization, and evaluation

In this research, hydrogels based on chitosan, pectin, and salt (NaCl) were synthesized through the formation of polyelectrolyte complexes (PECs). The synthesis parameters, including pH, salinity, and polymer concentration, were varied to explore their influence. Weight and texture analysis revealed differences in hydrogel morphology. Swelling behavior studies showed hydrogels synthesized at pH 4 exhibiting higher swelling capacities. Additionally, the presence of salt affected the formation process. Thermal characterization showed a first decomposition step occurring around 180–224 °C. Morphological testing using SEM highlighted differences in pore size and distribution, notably when salt was included in the formulation (pore wall diameter without NaCl, 2.2 ± 1.1 um, with NaCl, 4.7 ± 1.2 um). Physico-chemical tests, including Zeta potential, FTIR, and XRD, provided insights into interactions within the hydrogels: hydrogen bonds and electrostatic interactions. Moreover, antibacterial tests demonstrated efficacy against Escherichia coli and Staphylococcus aureus, with varying inhibition degrees correlated with NaCl content (halo for E. coli without NaCl, 8 and 10 mm; with NaCl, 10 and 15 mm). Further assessments, including water vapor transmission rate (WVTR) and lidocaine release assays, highlighted hydrogel potential for wound dressing applications, with suitable moisture retention properties and controlled drug release capabilities. The release percentage achieved by the hydrogel with 0.15 M NaCl was higher than without salt (111.1% ± 9.5% and 31.16% ± 15.13%, respectively). Preliminary in vivo wound healing studies showed promising results. Overall, our findings emphasize the tunable properties of these hydrogels and their potential for wound dressings.

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来源期刊
Colloid and Polymer Science
Colloid and Polymer Science 化学-高分子科学
CiteScore
4.60
自引率
4.20%
发文量
111
审稿时长
2.2 months
期刊介绍: Colloid and Polymer Science - a leading international journal of longstanding tradition - is devoted to colloid and polymer science and its interdisciplinary interactions. As such, it responds to a demand which has lost none of its actuality as revealed in the trends of contemporary materials science.
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