交联对稗子(Echinochloa frumentacea)谷物淀粉的理化和生理特性的影响

Starch Pub Date : 2024-05-10 DOI:10.1002/star.202300285
Pankaj Bhatt, Suruchi Singh, Sakshi Garg, P. Ashoka, Shardandu Kumar Mishra, Shikha Kaushik, Varsha Deva, Richa Goel, Vipin Kumar
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摘要

稗子淀粉(Echinochloa frumentacea)因其独特的性质而被研究用于药物输送系统的潜力。本研究使用不同浓度的三聚磷酸钠(STPP)研究了交联稗淀粉(BMS)的物理化学和生理特性。研究分析了交联淀粉的物理化学和生理特性。交联导致淀粉样品的溶胀能力和溶解度降低。形态分析表明,交联淀粉表面粗糙,有空洞和微小裂缝。对试验动物进行的急性和亚急性毒性研究表明,交联淀粉对动物没有不良影响,半数致死剂量为 2000 毫克/千克,在可接受范围内。与对照组相比,血液、生化和脂质概况没有发生明显变化。研究表明 STPP 交联淀粉的急性毒性水平较低,安全性良好。这些发现凸显了交联稗淀粉作为载体在药物输送系统和食品应用中的潜力。这项研究支持交联稗淀粉在药物制剂中的应用潜力。
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Impact of Cross‐Linking on the Physicochemical and Physiological Characteristics of Barnyard Millet (Echinochloa frumentacea) Grains Starch
Barnyard millet starch (Echinochloa frumentacea) has been investigated for its potential in drug delivery systems due to its unique properties. This study examined the physicochemical and physiological properties of cross‐linked barnyard millet starch (BMS) using varying concentrations of sodium tripolyphosphate (STPP). Physicochemical and physiological properties of the cross‐linked starches are analyzed. Cross‐linking resulted in reduced swelling capacity and solubility of starch samples. Morphological analysis revealed rough surfaces with cavities and minute cracks in cross‐linked starches. Acute and sub‐acute toxicity studies in test animals indicated no adverse effects, with LD50 values within acceptable limits at 2000 mg kg−1. Hematological, biochemical, and lipid profiles showed no significant alterations compared to the control group. The study demonstrated a low acute toxicity level and favorable safety profile for STPP‐cross‐linked starch. These findings highlighted the potential of cross‐linked barnyard millet starch as a carrier in drug delivery system and for food applications. This study supports the potential of cross‐linked barnyard millet starch in pharmaceutical formulations.
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