静脉输液过程中人体尿液排泄和跨血管液体交换的模式:定量分析。

IF 1.3 4区 医学 Q4 PHYSIOLOGY Clinical Physiology and Functional Imaging Pub Date : 2024-05-16 DOI:10.1111/cpf.12887
FitzRoy E. Curry, C. Charles Michel
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引用次数: 0

摘要

导言:有关动物和人类对血浆容量变化的反应的调查报告通常是以群体个体的平均反应为基础的。这忽略了个体之间相当大的数量差异。我们研究了一个假设,即个体反应遵循一个共同的时间模式,其变化反映了描述该模式的不同参数:我们使用 Hahn、Lindahl 和 Drobin(Acta Anaesthesiol Scand.2011,55:987-94)的数据说明了这种方法,他们测量了 10 名女性受试者在静脉注射林格液 30 分钟和随后 3.5 小时内的尿量和血红蛋白稀释情况:结果:尿液排泄的特点是尿流增加前的时间延迟(Td)和用对数函数描述的累积尿液排泄时间过程。这种对数关系构成了描述尿液排泄量与 Td 关系的一系列线性关系的理论基础。测量 Td 可以估算出随后的尿液排泄值,从而估算出输液在体内的留存率:当测试和对照组的反应都可以用特定时间的累积尿量与 Td 之间的线性关系来描述时,这种方法可能有助于生理学家和临床研究人员比较输液方案的反应。该方法还可用于临床医生,补充指导输液治疗的策略,从个体的早期反应预测其后期反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The patterns in urine excretion and transvascular fluid exchange in human subjects during intravenous fluid infusion: A quantitative analysis

Introduction

Investigations of responses of animals and humans to changes of plasma volume are usually reported as average responses of groups of individuals. This ignores considerable quantitative variation between individuals. We examined the hypothesis that individual responses follow a common temporal pattern with variations reflecting different parameters describing that pattern.

Methods

We illustrate this approach using data of Hahn, Lindahl and Drobin (Acta Anaesthesiol Scand.2011, 55:987-94) who measured urine volume and haemoglobin dilution of 10 female subjects during intravenous Ringer infusions for 30 min and subsequent 3.5 h. The published time courses were digitised and analysed to determine if a family of mathematical functions accounted for the variation in individual responses.

Results

Urine excretion was characterised by a time delay (Td) before urine flow increased and a time course of cumulative urine excretion described by a logarithmic function. This logarithmic relation forms the theoretical basis of a family of linear relations describing urine excretion as a function of Td. Measurement of Td enables estimation of subsequent values of urine excretion and thereby the fraction of infused fluid retained in the body.

Conclusion

The approach might be useful for physiologists and clinical investigators to compare the response to infusion protocols when both test and control responses can be described by linear relations between cumulative urine volume at specific times and Td. The approach may also be useful for clinicians by complementing strategies to guide fluid therapy by enabling the later responses of an individual to be predicted from their earlier response.

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来源期刊
CiteScore
3.40
自引率
5.60%
发文量
62
审稿时长
6-12 weeks
期刊介绍: Clinical Physiology and Functional Imaging publishes reports on clinical and experimental research pertinent to human physiology in health and disease. The scope of the Journal is very broad, covering all aspects of the regulatory system in the cardiovascular, renal and pulmonary systems with special emphasis on methodological aspects. The focus for the journal is, however, work that has potential clinical relevance. The Journal also features review articles on recent front-line research within these fields of interest. Covered by the major abstracting services including Current Contents and Science Citation Index, Clinical Physiology and Functional Imaging plays an important role in providing effective and productive communication among clinical physiologists world-wide.
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