Kai Michael Schubert, Giulio Bicciato, Lucia Sinka, Laura Abraira, Estevo Santamarina, José Álvarez-Sabín, Carolina Ferreira-Atuesta, Mira Katan, Natalie Scherrer, Robert Terziev, Nico Döhler, Barbara Erdélyi-Canavese, Ansgar Felbecker, Philip Siebel, Michael Winklehner, Tim J von Oertzen, Judith N Wagner, Gian Luigi Gigli, Annacarmen Nilo, Francesco Janes, Giovanni Merlino, Mariarosaria Valente, María Paula Zafra-Sierra, Luis Carlos Mayor-Romero, Julian Conrad, S Evers, Piergiorgio Lochner, Frauke Roell, Francesco Brigo, Carla Bentes, Rita Peralta, Teresa Pinho E Melo, Mark R Keezer, John Sidney Duncan, Josemir W Sander, Barbara Tettenborn, Matthias Koepp, Marian Galovic
{"title":"缺血性中风后癫痫发作风险对驾驶的影响。","authors":"Kai Michael Schubert, Giulio Bicciato, Lucia Sinka, Laura Abraira, Estevo Santamarina, José Álvarez-Sabín, Carolina Ferreira-Atuesta, Mira Katan, Natalie Scherrer, Robert Terziev, Nico Döhler, Barbara Erdélyi-Canavese, Ansgar Felbecker, Philip Siebel, Michael Winklehner, Tim J von Oertzen, Judith N Wagner, Gian Luigi Gigli, Annacarmen Nilo, Francesco Janes, Giovanni Merlino, Mariarosaria Valente, María Paula Zafra-Sierra, Luis Carlos Mayor-Romero, Julian Conrad, S Evers, Piergiorgio Lochner, Frauke Roell, Francesco Brigo, Carla Bentes, Rita Peralta, Teresa Pinho E Melo, Mark R Keezer, John Sidney Duncan, Josemir W Sander, Barbara Tettenborn, Matthias Koepp, Marian Galovic","doi":"10.1136/jnnp-2024-333505","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>In addition to other stroke-related deficits, the risk of seizures may impact driving ability after stroke.</p><p><strong>Methods: </strong>We analysed data from a multicentre international cohort, including 4452 adults with acute ischaemic stroke and no prior seizures. We calculated the Chance of Occurrence of Seizure in the next Year (COSY) according to the SeLECT<sub>2.0</sub> prognostic model. We considered COSY<20% safe for private and <2% for professional driving, aligning with commonly used cut-offs.</p><p><strong>Results: </strong>Seizure risks in the next year were mainly influenced by the baseline risk-stratified according to the SeLECT<sub>2.0</sub> score and, to a lesser extent, by the poststroke seizure-free interval (SFI). Those without acute symptomatic seizures (SeLECT<sub>2.0</sub> 0-6 points) had low COSY (0.7%-11%) immediately after stroke, not requiring an SFI. In stroke survivors with acute symptomatic seizures (SeLECT<sub>2.0</sub> 3-13 points), COSY after a 3-month SFI ranged from 2% to 92%, showing substantial interindividual variability. Stroke survivors with acute symptomatic status epilepticus (SeLECT<sub>2.0</sub> 7-13 points) had the highest risk (14%-92%).</p><p><strong>Conclusions: </strong>Personalised prognostic models, such as SeLECT<sub>2.0</sub>, may offer better guidance for poststroke driving decisions than generic SFIs. Our findings provide practical tools, including a smartphone-based or web-based application, to assess seizure risks and determine appropriate SFIs for safe driving.</p>","PeriodicalId":16418,"journal":{"name":"Journal of Neurology, Neurosurgery, and Psychiatry","volume":null,"pages":null},"PeriodicalIF":8.7000,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Implications for driving based on the risk of seizures after ischaemic stroke.\",\"authors\":\"Kai Michael Schubert, Giulio Bicciato, Lucia Sinka, Laura Abraira, Estevo Santamarina, José Álvarez-Sabín, Carolina Ferreira-Atuesta, Mira Katan, Natalie Scherrer, Robert Terziev, Nico Döhler, Barbara Erdélyi-Canavese, Ansgar Felbecker, Philip Siebel, Michael Winklehner, Tim J von Oertzen, Judith N Wagner, Gian Luigi Gigli, Annacarmen Nilo, Francesco Janes, Giovanni Merlino, Mariarosaria Valente, María Paula Zafra-Sierra, Luis Carlos Mayor-Romero, Julian Conrad, S Evers, Piergiorgio Lochner, Frauke Roell, Francesco Brigo, Carla Bentes, Rita Peralta, Teresa Pinho E Melo, Mark R Keezer, John Sidney Duncan, Josemir W Sander, Barbara Tettenborn, Matthias Koepp, Marian Galovic\",\"doi\":\"10.1136/jnnp-2024-333505\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>In addition to other stroke-related deficits, the risk of seizures may impact driving ability after stroke.</p><p><strong>Methods: </strong>We analysed data from a multicentre international cohort, including 4452 adults with acute ischaemic stroke and no prior seizures. We calculated the Chance of Occurrence of Seizure in the next Year (COSY) according to the SeLECT<sub>2.0</sub> prognostic model. We considered COSY<20% safe for private and <2% for professional driving, aligning with commonly used cut-offs.</p><p><strong>Results: </strong>Seizure risks in the next year were mainly influenced by the baseline risk-stratified according to the SeLECT<sub>2.0</sub> score and, to a lesser extent, by the poststroke seizure-free interval (SFI). Those without acute symptomatic seizures (SeLECT<sub>2.0</sub> 0-6 points) had low COSY (0.7%-11%) immediately after stroke, not requiring an SFI. In stroke survivors with acute symptomatic seizures (SeLECT<sub>2.0</sub> 3-13 points), COSY after a 3-month SFI ranged from 2% to 92%, showing substantial interindividual variability. Stroke survivors with acute symptomatic status epilepticus (SeLECT<sub>2.0</sub> 7-13 points) had the highest risk (14%-92%).</p><p><strong>Conclusions: </strong>Personalised prognostic models, such as SeLECT<sub>2.0</sub>, may offer better guidance for poststroke driving decisions than generic SFIs. Our findings provide practical tools, including a smartphone-based or web-based application, to assess seizure risks and determine appropriate SFIs for safe driving.</p>\",\"PeriodicalId\":16418,\"journal\":{\"name\":\"Journal of Neurology, Neurosurgery, and Psychiatry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":8.7000,\"publicationDate\":\"2024-08-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Neurology, Neurosurgery, and Psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1136/jnnp-2024-333505\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neurology, Neurosurgery, and Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/jnnp-2024-333505","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Implications for driving based on the risk of seizures after ischaemic stroke.
Background: In addition to other stroke-related deficits, the risk of seizures may impact driving ability after stroke.
Methods: We analysed data from a multicentre international cohort, including 4452 adults with acute ischaemic stroke and no prior seizures. We calculated the Chance of Occurrence of Seizure in the next Year (COSY) according to the SeLECT2.0 prognostic model. We considered COSY<20% safe for private and <2% for professional driving, aligning with commonly used cut-offs.
Results: Seizure risks in the next year were mainly influenced by the baseline risk-stratified according to the SeLECT2.0 score and, to a lesser extent, by the poststroke seizure-free interval (SFI). Those without acute symptomatic seizures (SeLECT2.0 0-6 points) had low COSY (0.7%-11%) immediately after stroke, not requiring an SFI. In stroke survivors with acute symptomatic seizures (SeLECT2.0 3-13 points), COSY after a 3-month SFI ranged from 2% to 92%, showing substantial interindividual variability. Stroke survivors with acute symptomatic status epilepticus (SeLECT2.0 7-13 points) had the highest risk (14%-92%).
Conclusions: Personalised prognostic models, such as SeLECT2.0, may offer better guidance for poststroke driving decisions than generic SFIs. Our findings provide practical tools, including a smartphone-based or web-based application, to assess seizure risks and determine appropriate SFIs for safe driving.
期刊介绍：
The Journal of Neurology, Neurosurgery & Psychiatry (JNNP) aspires to publish groundbreaking and cutting-edge research worldwide. Covering the entire spectrum of neurological sciences, the journal focuses on common disorders like stroke, multiple sclerosis, Parkinson’s disease, epilepsy, peripheral neuropathy, subarachnoid haemorrhage, and neuropsychiatry, while also addressing complex challenges such as ALS. With early online publication, regular podcasts, and an extensive archive collection boasting the longest half-life in clinical neuroscience journals, JNNP aims to be a trailblazer in the field.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
