PD-1 在肿瘤发生中的多重作用:从免疫检查点到肿瘤细胞内在功能

IF 3 2区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Carcinogenesis Pub Date : 2024-08-01 Epub Date: 2024-05-15 DOI:10.1002/mc.23740
Huiqing Chen, Jiayu Wei, Zhen Zhu, Yongzhong Hou
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引用次数: 0

摘要

程序性细胞死亡 1(PD-1)是一种关键的免疫检查点受体,它在调节癌症免疫反应方面的作用已被广泛研究。然而,最近的研究揭示了 PD-1 在肿瘤发生中的复杂和双重作用。虽然 PD-1 传统上与免疫细胞有关,但本文探讨了它在各种癌细胞中的表达及其对癌症进展的影响。PD-1 的功能超出了免疫调节的范畴,因为它既能促进肿瘤生长,也能抑制肿瘤生长,这取决于癌症的类型。这些发现对未来的癌症治疗以及我们对癌症免疫反应的理解具有重要意义。本文呼吁进一步研究 PD-1 的多方面作用,以优化其治疗潜力,改善患者的抗癌疗效。
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Multifaceted roles of PD-1 in tumorigenesis: From immune checkpoint to tumor cell-intrinsic function.

Programmed cell death 1 (PD-1), a key immune checkpoint receptor, has been extensively studied for its role in regulating immune responses in cancer. However, recent research has unveiled a complex and dual role for PD-1 in tumorigenesis. While PD-1 is traditionally associated with immune cells, this article explores its expression in various cancer cells and its impact on cancer progression. PD-1's functions extend beyond immune regulation, as it has been found to both promote and suppress tumor growth, depending on the cancer type. These findings have significant implications for the future of cancer treatment and our understanding of the immune response in the context of cancer. This article calls for further research into the multifaceted roles of PD-1 to optimize its therapeutic potential and improve patient outcomes in the fight against cancer.

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来源期刊
Molecular Carcinogenesis
Molecular Carcinogenesis 医学-生化与分子生物学
CiteScore
7.30
自引率
2.20%
发文量
112
审稿时长
2 months
期刊介绍: Molecular Carcinogenesis publishes articles describing discoveries in basic and clinical science of the mechanisms involved in chemical-, environmental-, physical (e.g., radiation, trauma)-, infection and inflammation-associated cancer development, basic mechanisms of cancer prevention and therapy, the function of oncogenes and tumors suppressors, and the role of biomarkers for cancer risk prediction, molecular diagnosis and prognosis.
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